Results 41 to 50 of about 1,260,577 (268)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Anti-aging Effects and Main Chemical Constituents of Stem Extracts

Natural Product Communications
Objective: To investigate the anti-aging effects and the main chemical constituents of Spiraea salicifolia stem extracts. Methods: The anti-aging effects were investigated by evaluating the antioxidant, anti-wrinkle, and anti-inflammatory properties. The
Gwee Kyo Park, Jin Yeong Song, Hye-Young Yoo, Minseo Kwon, You Ah Kim, Sung-Ha Park, Ki Yong Lee, Byoung Jun Park   +7 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A Review on the Edible Bird’s Nest Quality and Manufacturing Standards of the Three Largest Exporting Countries in the World

Journal of Food Quality
Edible bird’s nest (EBN) is an animal product with the world’s highest market price due to its value. The nests are made exclusively from the saliva secreted by swiftlet, a species of bird native to Southeast Asia.
Nurin Naziha Zulkefle, Mohamed Ahmed Ibrahim, Nor Fateha Azuan, Soo Ee Ch’ng, Norsharina Ismail, Md Zuki Abu Bakar, Kim Wei Chan   +6 more
doaj   +1 more source

Bioactive Natural Products [PDF]

Journal of Chemistry, 2013
Bioactive natural products have never ceased to play an important role in the search of novel therapeutic agents. Natural products from the nature such as the plant and marine sources form an integral part of the living system, and they have existed ever since the beginning of life.Therefore, it is undeniable that works related to natural products ...
Hadi, A. Hamid A., Duru, Mehmet Emin, Martin-Diana, Ana B.   +2 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

InertDB as a generative AI-expanded resource of biologically inactive small molecules from PubChem

Journal of Cheminformatics
The development of robust artificial intelligence (AI)-driven predictive models relies on high-quality, diverse chemical datasets. However, the scarcity of negative data and a publication bias toward positive results often hinder accurate biological ...
Seungchan An, Yeonjin Lee, Junpyo Gong, Seokyoung Hwang, In Guk Park, Jayhyun Cho, Min Ju Lee, Minkyu Kim, Yun Pyo Kang, Minsoo Noh   +9 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Antimicrobial photodynamic therapy with Ligularia fischeri against methicillin-resistant Staphylococcus aureus infection in Caenorhabditis elegans model

Applied Biological Chemistry, 2023
The high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) infection threatens the effectiveness of current clinical settings. Antimicrobial photodynamic therapy (APDT) is a promising alternative to antibiotics for treating infections due ...
Ngoc Minh Ha, Hoseong Hwang, Seemi Tasnim Alam, Uyen Tran Tu Nguyen, Soon Kwang Lee, Jin-Soo Park, Jin-Chul Kim, Hak Cheol Kwon, Jaeyoung Kwon, Kyungsu Kang   +9 more
doaj   +1 more source