Results 71 to 80 of about 9,605,578 (343)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla

Molecules, 2015
One new benzofuran, (2R)-(2',4'-dihydroxybenzyl)-6,7-methylenedioxy-2,3-dihydrobenzofuran (1), one new phenylisocoumarin, 3-(2'-hydroxyphenyl)-6,8-dihydroxy-7-methoxy-isocoumarin (2), and one new benzofuroisocoumarin, platyphyllarin C (3), were isolated ...
Yu-Chi Tsai, Chia-Chun Hsu, Mohamed El-Shazly, Shang-Yu Chiang, Chau-Chung Wu, Chin-Chung Wu, Wan-Chun Lai, Ming-Hong Yen, Yang-Chang Wu, Fang-Rong Chang   +9 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

InertDB as a generative AI-expanded resource of biologically inactive small molecules from PubChem

Journal of Cheminformatics
The development of robust artificial intelligence (AI)-driven predictive models relies on high-quality, diverse chemical datasets. However, the scarcity of negative data and a publication bias toward positive results often hinder accurate biological ...
Seungchan An, Yeonjin Lee, Junpyo Gong, Seokyoung Hwang, In Guk Park, Jayhyun Cho, Min Ju Lee, Minkyu Kim, Yun Pyo Kang, Minsoo Noh   +9 more
doaj   +1 more source

Translating CO $$_2$$ 2 variability in a plant growth system into plant dynamics

Scientific Reports, 2022
Plant growth occurs owing to the continuous interactions between environmental and genetic factors, and the analysis of plant growth provides crucial information on plant responses.
Tae In Ahn, Je Hyeong Jung, Hyoung Seok Kim, Ju Young Lee   +3 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

A Review on the Edible Bird’s Nest Quality and Manufacturing Standards of the Three Largest Exporting Countries in the World

Journal of Food Quality
Edible bird’s nest (EBN) is an animal product with the world’s highest market price due to its value. The nests are made exclusively from the saliva secreted by swiftlet, a species of bird native to Southeast Asia.
Nurin Naziha Zulkefle, Mohamed Ahmed Ibrahim, Nor Fateha Azuan, Soo Ee Ch’ng, Norsharina Ismail, Md Zuki Abu Bakar, Kim Wei Chan   +6 more
doaj   +1 more source

Imidazopyridine hydrazone derivatives exert antiproliferative effect on lung and pancreatic cancer cells and potentially inhibit receptor tyrosine kinases including c-Met

Scientific Reports, 2021
Aberrant activation of c-Met signalling plays a prominent role in cancer development and progression. A series of 12 imidazo [1,2-α] pyridine derivatives bearing 1,2,3-triazole moiety were designed, synthesized and evaluated for c-Met inhibitory ...
Tahereh Damghani, Fatemeh Moosavi, Mehdi Khoshneviszadeh, Motahareh Mortazavi, Somayeh Pirhadi, Zahra Kayani, Luciano Saso, Najmeh Edraki, Omidreza Firuzi   +8 more
doaj   +1 more source

Metabolomics in the Context of Plant Natural Products Research: From Sample Preparation to Metabolite Analysis

Metabolites, 2020
Plant-derived natural products have long been considered a valuable source of lead compounds for drug development. Natural extracts are usually composed of hundreds to thousands of metabolites, whereby the bioactivity of natural extracts can be ...
M. Salem, Leonardo Perez de Souza, A. Serag, A. Fernie, M. Farag, S. Ezzat, S. Alseekh   +6 more
semanticscholar   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source