Results 91 to 100 of about 12,832,013 (404)

Brief history of natural sciences for nature-inspired computing in engineering

, 2016
The goal of the authors is adroit integration of three mainstream disciplines of the natural sciences, physics, chemistry and biology to create novel problem solving paradigms.
N. Siddique, H. Adeli
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Optical characteristics of laser medical instrument with side-firing fiber under complete bevel angle range

iScience
Summary: The side-firing instrument is studied under the complete bevel angle range. The fiber core and cladding are 0.6 mm and 0.66 mm, respectively, the fiber core refractive index is 1.457, and the fiber cladding refractive index is from 1.409 to 1 ...
Diqing Ying
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

The first specific probe for pyrrolidine with multifunction by the interaction mechanism of atomic economic reaction

iScience
Summary: Pyrrolidine (PyD) has an important impact on the environment and human health. However, there is currently no method for trace detection of PyD. Here, we successfully designed diaminomethylene-4H-pyran (1) as the first specific fluorescent probe
Xi-Ying Cao, Yan Huang, Si-Hong Chen, Shi-Wei Yu, Zu-Jia Chen, Zhong-Hao Li, Yu Zeng, Nan Chen, Liang Cao, Zhao-Yang Wang   +9 more
doaj   +1 more source

Natural history and community science records confirm rapid geographic shifts in the distribution of Bachman’s Sparrow (Peucaea aestivalis) since 1850 [PDF]

, 2022
Amie E. Settlecowski, Kathryn E C Davis, James A. Cox, Stefan Woltmann, Sabrina S. Taylor   +4 more
openalex   +1 more source

Reduction [PDF]

, 2016
Reduction and reductionism have been central philosophical topics in analytic philosophy of science for more than six decades. Together they encompass a diversity of issues from metaphysics and epistemology.
Hüttemann, Andreas, Love, Alan
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Benefits of space research to the natural sciences [PDF]

The use of space technology to develop techniques and devices to help support the American dollar and determine the origin of the moon and solar system is ...
Okeefe, J. A.
core   +1 more source

Creation's Persistent Voice: Critiquing the Secondary Status [PDF]

, 2012
Christianity struggles with the concept that nature/creation is truly revelatory of God, and not merely confirmatory of theological conclusions derived from special revelation or deduced from rational reflection.
Bouma, Rolf
core   +1 more source