Results 91 to 100 of about 5,166,609 (350)
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Dishevelled localization and function are differentially regulated by structurally distinct sterols
iScienceSummary: The Dishevelled (DVL) protein family forms supramolecular protein and lipid complexes at the cytoplasmic interface of the plasma membrane to regulate tissue patterning, proliferation, cell polarity, and DVL-dependent signaling, such as Wnt/β ...
Sonali Sengupta +5 more
doaj +1 more source
Scientific Knowledge in Aristotle’s Biology [PDF]
, 2015 Aristotle was the first thinker to articulate a taxonomy of scientific knowledge, which he set out in Posterior Analytics. Furthermore, the “special sciences”, i.e., biology, zoology and the natural sciences in general, originated with Aristotle.
Botter, Barbara
core
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
IFN-γ licenses normal and pathogenic ALPK1/TIFA pathway in human monocytes
iScienceSummary: Alpha-kinase 1 (ALPK1) is an immune receptor sensing the bacterial nucleotide sugar ADP-heptose. ALPK1 phosphorylates TIFA leading to its oligomerization and downstream NF-κB activation.
Amandine Martin +10 more
doaj +1 more source
, 2013 The UAF School of Natural Resources & Agricultural Sciences and Agricultural & Forestry Experiment Station have been working for the last decade on a long-term project exploring the potential for the cut flower market in the 49th state—which looks ...
Zhang, Mingchu
core
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
iScienceSummary: Life cycle Human System Integration (HSI) practices are crucial for optimizing human system performance, reducing costs, and ensuring safety. To address the limited HSI practices under typical Human Readiness Levels (HRLs), our study proposes an
Chuanyan Feng +4 more
doaj +1 more source
Digital Preservation and Access of Natural Resources Documents [PDF]
, 2017 Digitization and preservation of natural resource documents were reviewed and the current status of digitization presented for a North American university.
Bullard, Steven H +4 more
core +2 more sources