Results 91 to 100 of about 5,415,293 (346)

Thomas Torrance\u27s Reformulation of Karl Barth\u27s Christological Rejection of Natural Theology [PDF]

open access: yes, 2001
Karl Barth is widely noted for his antipathy to all forms of natural theology. Indeed, the results of Barth’s Christocentricity have made his name synonymous with the negation of all divine revelation apart from Christ, the one Word of God.
Morrison, John D.
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Positioning, navigation, and timing on the Moon and Mars with galactic cosmic rays

open access: yesiScience
Summary: The muometric wireless navigation system (MuWNS) is a technology enabling signal reception for machine controlling and communication systems underground where a radio or GPS signal would normally be lost.
G. Leone   +14 more
doaj   +1 more source

TREX1, a predator for treating MSI‐H tumors?

open access: yesMolecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya   +2 more
wiley   +1 more source

A human-system integration framework and its application for special vehicle interface design under typical human readiness levels

open access: yesiScience
Summary: Life cycle Human System Integration (HSI) practices are crucial for optimizing human system performance, reducing costs, and ensuring safety. To address the limited HSI practices under typical Human Readiness Levels (HRLs), our study proposes an
Chuanyan Feng   +4 more
doaj   +1 more source

Alaska's Food (In)Security, Climate Change and the Boreal Forest, Biomass and Hydrocarbons [PDF]

open access: yes, 2010
[Geography] -- AMSA: the future of arctic marine shipping: With more shipping traffic in the north and greater marine access due to the retreat of Arctic sea ice, the Arctic states needed to develop a strategy to protect the maritime Arctic, its people ...
School of Natural Resources and Agricultural Sciences, Agricultural and Forestry Experiment Station, University of Alaska Fairbanks
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Polarization-insensitive narrowband reflective wavefront manipulation through all-dielectric anisotropic subwavelength structures

open access: yesiScience
Summary: Local metasurfaces provide high flexibility in shaping wavefronts but suffer from poor frequency selectivity. Here, we numerically present a reflective all-dielectric metasurface platform achieving simultaneous local phase control and spectral ...
Meiyan Pan   +3 more
doaj   +1 more source

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