Results 41 to 50 of about 12,832,013 (404)

Does economics need a scientific revolution? [PDF]

, 2009
Economics does not need a scientific revolution. Economics needs accurate measurements according to high standards of natural sciences and meticulous work on revealing empirical relationships between measured variables.Comment: 6 pages, 3 ...
Kitov, Ivan O.
core   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Basin dependencies of tropical cyclone genesis environment and possible future changes revealed by machine learning methods

iScience
Summary: Tropical cyclone (TC) genesis mechanisms remain debated, complicating predictions of climate change impacts. This study uses principal-component analysis (PCA), confidence ellipses, and correlation circles to analyze TC genesis environments ...
QiFeng Qian, YeFeng Chen, XiaoJing Jia, Hao Ma, Wei Dong   +4 more
doaj   +1 more source

Explanation and Understanding Revisited [PDF]

, 2017
"Explanation and Understanding" (1971) by Georg Henrik von Wright is a modern classic in analytic hermeneutics, and in the philosophy of the social sciences and humanities in general.
Raatikainen, Panu
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

A contactless monitoring system for accurately predicting energy expenditure during treadmill walking based on an ensemble neural network

iScience
Summary: The monitoring of treadmill walking energy expenditure (EE) plays an important role in health evaluations and management, particularly in older individuals and those with chronic diseases.
Shangjun Huang, Houde Dai, Xiaoming Yu, Xie Wu, Kuan Wang, Jiaxin Hu, Hanchen Yao, Rui Huang, Wenxin Niu   +8 more
doaj   +1 more source

Why Study History? On Its Epistemic Benefits and Its Relation to the Sciences [PDF]

, 2017
I try to return the focus of the philosophy of history to the nature of understanding, with a particular emphasis on Louis Mink’s project of exploring how historical understanding compares to the understanding we find in the natural sciences.
Grimm, Stephen R.
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Multicenter study for CH-VAD as a fully magnetically levitated left ventricular assist device

iScience
Summary: The CH-VAD is a fully magnetically levitated left ventricular assist device (LVAD) designed for optimized hemocompatibility. This study evaluates the clinical outcomes of 77 patients implanted with the CH-VAD across seven centers in China from ...
Yifan Lu, Shuanglei Zhao, Jie Han, Qiang Lv, Xin Du, Zhengdong Hua, Keli Huang, Zhenwei Ge, Xiaoning Sun, Dan Zhu, Yongfeng Shao, Hongjia Zhang, Ming Gong   +12 more
doaj   +1 more source

Peeling back the layers of coral holobiont multi-omics data

iScience, 2023
Summary: The integration of multiple ‘omics’ datasets is a promising avenue for answering many important and challenging questions in biology, particularly those relating to complex ecological systems.
Amanda Williams, Timothy G. Stephens, Alexander Shumaker, Debashish Bhattacharya   +3 more
doaj   +1 more source