Results 61 to 70 of about 2,055,109 (284)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Optical multilayer thin film structure inverse design: From optimization to deep learning

iScience
Summary: Optical multilayer thin film structures have been widely used in numerous photonic domains and applications. The key component to enable these applications is the inverse design.
Taigao Ma, Mingqian Ma, L. Jay Guo
doaj   +1 more source

The nature of science. A dialogue

Synthese, 2016
In this dialogue the view of Paul Hoyningen-Huene as defended in Systematicity. The Nature of Science is presented and criticized. The approach is developed dialectically by the two interlocutors, a series of critical points are debated and an alternative view is introduced. The dialogical form is intended to honor the general philosophical approach of
openaire   +2 more sources

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Soft wearable thermo+touch haptic interface for virtual reality

iScience
Summary: Touch is an inherent source of tactile sensation in everyday life, followed by vision and audition. For rich tactile feedback, multimodal haptic feedback is necessary because a single touch simultaneously excites multiple types of tactile ...
Seohu Lee, Seongkwan Jang, Youngsu Cha
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Negative regulation of lymphangiogenesis by Tenascin-C delays the resolution of inflammation

iScience
Summary: Lymphatic vessels are required for the clearance of excess fluid and immune cells from inflamed tissue, making the regulation of lymphangiogenesis an important area of research.
Daisuke Katoh, Yoshiyuki Senga, Kento Mizutani, Kazuaki Maruyama, Daishi Yamakawa, Tadashi Yamamuro, Michiaki Hiroe, Keiichi Yamanaka, Akihiro Sudo, Naoyuki Katayama, Toshimichi Yoshida, Kyoko Imanaka-Yoshida   +11 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Enhanced global extreme droughts driven by the Indian Ocean and Pacific Ocean on decadal timescales

iScience
Summary: In the 21st century, two record-breaking years of extreme drought coverage swept across the globe. These resulted in billions of agriculture losses and led to hunger and poverty in those developing countries.
Yihui Xu, Xiaodan Guan, Jianping Huang, Shi Jin, Zhiyuan Jin   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source