Results 81 to 90 of about 12,832,013 (404)

Roles and therapeutic opportunities of ω-3 long-chain polyunsaturated fatty acids in lung cancer

iScience
Summary: Over the past decades, researchers have continuously investigated the potential functions of long-chain polyunsaturated fatty acids (LCPUFAs) in cancers, including lung cancer.
Jiang Luo, Shu Peng, Ziyu Jiang, Qingwei Wang, Mini Zhang, Yuxin Zeng, Yu Yuan, Min Xia, Zixi Hong, Yufei Yan, Yushuang Tan, Jiawen Tang, Conghua Xie, Yan Gong   +13 more
doaj   +1 more source

A coupled hydrology-biogeochemistry model to simulate dissolved organic carbon exports from a permafrost influenced catchment [PDF]

, 2015
Funded by Natural Environment Research Council. Grant Number: NE/K000268/1 Natural Sciences and Engineering Research Council of CanadaPeer reviewedPublisher ...
Abdalla, Balcarczyk, Beven, Beven, Beven, Birkel, Bishop, Boyer, Carey, Carey, Carey, Carey, Cole, Cory, Criss, Dick, Dornes, Dye, Eddelbuettel, Eddelbuettel, Finlay, Frey, Futter, Gray, Guo, Guo, Guo, Gupta, Hamilton, Hamilton, Holmes, Holmes, Hottelet, Hugelius, Jutras, Kawahigashi, Kicklighter, Koch, Konz, Krause, Laudon, Lenton, Lewkowicz, Lindström, Lyon, Mann, McCartney, McClelland, McGuire, McNamara, Michalzik, Neff, O'Donnell, Oelke, Petrone, Prokushkin, Quinton, Quinton, Quinton, Raymond, Schoups, Schuur, Smith, Smith, Striegl, Tank, Tetzlaff, Thornthwaite, Tjoelker, Van Griensven, Wickland, Zambrano-Bigiarini, Zou   +72 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Cutting-edge microneedle innovations: Transforming the landscape of cardiovascular and metabolic disease management

iScience
Summary: Cardiovascular diseases (CVDs) and metabolic disorders (MDs) have surfaced as formidable challenges to global health, significantly imperiling human well-being. Recently, microneedles (MNs) have garnered substantial interest within the realms of
Xiaoning Zhang, Ming Li, Qiang Gao, Xiaoya Kang, Jingyao Sun, Yao Huang, Hong Xu, Jing Xu, Songren Shu, Jian Zhuang, Yuan Huang   +10 more
doaj   +1 more source

Paradigm shift in determining Neoproterozoic atmospheric oxygen [PDF]

, 2016
ACKNOWLEDGMENTS We thank the Geological Survey of Australia for permission to sample the Empress 1A and Lancer 1 cores, the Natural Sciences and Engineering Research Council of Canada for financial support (grant #7961–15) of U.
Benison, Kathleen, Blamey, Nigel J. F., Brand, Uwe, Lécuyer, Christophe, Meng, Fanwei, Ni, Pei, Parnell, John, Spear, Natalie   +7 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Epistemolojik Katmanlar: 18. Yüzyıl Ortası Avrupa Kültürü Örneği Üzerine Kültürel Paradigmalardaki Değişimlerin Analizi [PDF]

, 2019
Before this study, the author was tasked with identifying general tendencies of changes in values and dominant ideas in all spheres of cognition. During the study different branches of knowledge of one period and one civilization area are compared.
Шепетяк, Олег Михайлович
core  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Learning, economies of scale, and knowledge gap effects on power generation technology cost improvements

iScience
Summary: Cost reductions are essential for accelerating clean technology deployment. Because multiple factors influence costs, traditional one-factor learning models, solely relying on cumulative installed capacity as an explanatory variable, may ...
Yoga W. Pratama, Matthew J. Gidden, Jenna Greene, Andrew Zaiser, Gregory Nemet, Keywan Riahi   +5 more
doaj   +1 more source

Scientific Knowledge in Aristotle’s Biology [PDF]

, 2015
Aristotle was the first thinker to articulate a taxonomy of scientific knowledge, which he set out in Posterior Analytics. Furthermore, the “special sciences”, i.e., biology, zoology and the natural sciences in general, originated with Aristotle.
Botter, Barbara
core