Results 41 to 50 of about 4,039,102 (286)
História, Ciências, Saúde: Manguinhos, 2001 A teoria da evolução por seleção natural de Charles Darwin, ao relacionar os seres vivos genealogicamente, interpreta as espécies e sua fantástica diversidade como uma história de transformações lentas e graduais.
Ricardo Waizbort
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Genomic Legacies of Ancient Adaptation Illuminate GC-Content Evolution in Bacteria
Microbiology Spectrum, 2023 Bacterial evolution is characterized by strong purifying selection as well as rapid adaptive evolution in changing environments. In this context, the genomic GC content (genomic GC) varies greatly but presents some level of phylogenetic stability, making
Wenkai Teng +3 more
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The power of natural selection [PDF]
, 2002 In a recent paper, Steven Horst argued that if traditional physicalist accounts of consciousness cannot explain why there are conscious phenomena in the world then teleological accounts of consciousness that appeal to the notion of natural selection ...
Macpherson, F.
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Frontiers in Genetics, 2022 The major histocompatibility complex (MHC) is an important genomic region for adaptive immunity and has long been studied in ecological and evolutionary contexts, such as disease resistance and mate and kin selection.
Daren C. Card +8 more
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Natural Selection: A Stethoscopic Amphibious Installation. [PDF]
, 2005 This paper discusses emergence as a complex behaviour in the sound domain and presents a design strategy that was used in the creation of the sound installation Natural Selection to encourage the perception of sonic emergence. The interactions in Natural
Davis, Thomas, Rebelo, P.
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Natural Selection of Paths in Networks [PDF]
, 2011 We present a novel algorithm that exhibits natural selection of paths in a network. If each node and weighted directed edge has a unique identifier, a path in the network is defined as an ordered list of these unique identifiers.
Chrisantha Fernando +3 more
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
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