Results 71 to 80 of about 1,030,228 (245)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Why do we age? The main signs of aging

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Aging is a gradual and irreversible pathophysiological process. This is manifested in the decline of tissue and cell functions and a significant variety of pathologies associated with aging, including neurodegenerative diseases, cardiovascular diseases ...
Ugіs Kletnieks, Audrius Butkevichius, V. V. Hladyshev, S. S. Sоkolovskyi   +3 more
doaj   +1 more source

Detecting Selection on Protein Stability through Statistical Mechanical Models of Folding and Evolution

Biomolecules, 2014
The properties of biomolecules depend both on physics and on the evolutionary process that formed them. These two points of view produce a powerful synergism.
Ugo Bastolla
doaj   +1 more source

Signatures of Natural Selection on Mutations of Residues with Multiple Posttranslational Modifications [PDF]

, 2014
Vanessa E. Gray, Li Liu, R. Nirankari, Peter Hornbeck, Sudhir Kumar   +4 more
openalex   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Population genomic evidence of structured and connected Plasmodium vivax populations under host selection in Latin America

Ecology and Evolution
Pathogen genomic epidemiology has the potential to provide a deep understanding of population dynamics, facilitating strategic planning of interventions, monitoring their impact, and enabling timely responses, and thereby supporting control and ...
Johanna Helena Kattenberg, Pieter Monsieurs, Julie De Meyer, Katlijn De Meulenaere, Erin Sauve, Thaís C. deOliveira, Marcelo U. Ferreira, Dionicia Gamboa, Anna Rosanas‐Urgell   +8 more
doaj   +1 more source

A Framework for Feature Selection Using Natural Language Processing for User Profile Learning for Recommendations of Healthcare-Related Content

, 2021
Mona Tanwar, Sunil Kumar Khatri, Ravi Pendse   +2 more
openalex   +2 more sources

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Evidence for Natural Selection on Leukocyte Immunoglobulin-like Receptors for HLA Class I in Northeast Asians [PDF]

, 2008
Kouyuki Hirayasu, Jun Ohashi, Hidenori Tanaka, Koichi Kashiwase, Atsuko Ogawa, Minoko Takanashi, Masahiro Satake, Guan Jun Jia, Nyam‐Osor Chimge, Elena W. Sideltseva, Katsushi Tokunaga, Toshio Yabe   +11 more
openalex   +1 more source