Results 61 to 70 of about 6,442,499 (284)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
, 2023 The African Development Bank launched the Technologies for African Agriculture Transformation (TAAT) programme as part of the Bank’s Feed Africa strategy that is harnessing elite scientific research/technologies and disseminating at scale to African ...
Technologies for African Agricultural Transformation
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Frontiers in MicrobiologyThe rapid global dissemination of multidrug-resistant Acinetobacter baumannii poses a critical threat to public health, yet the role of the Type VI Secretion System (T6SS)—a contact-dependent interbacterial weapon—in shaping the antimicrobial resistome ...
Meng Zhang +7 more
doaj +1 more source
Structural characterization of the late competence protein ComFB from Bacillus subtilis
Bioscience Reports, 2015 Many bacteria take up DNA from their environment as part of the process of natural transformation. DNA uptake allows microorganisms to gain genetic diversity and can lead to the spread of antibiotic resistance or virulence genes within a microbial ...
Tatyana A. Sysoeva +6 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Diversity in Natural Transformation Frequencies and Regulation across
mBio, 2019 In Vibrio species, chitin-induced natural transformation enables bacteria to take up DNA from the external environment and integrate it into their genome.
Chelsea A. Simpson +4 more
doaj +1 more source
Exact solutions of the Laplace fractional boundary value problems via natural decomposition method
Open Physics, 2020 In this article, exact solutions of some Laplace-type fractional boundary value problems (FBVPs) are investigated via natural decomposition method. The fractional derivatives are described within Caputo operator.
Hajira +5 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source