Results 101 to 110 of about 40,568 (249)

Whom Should Entrepreneurs Approach? The Effect of Contact Status on Referring New Ventures for Acquisition

Journal of Management Studies, EarlyView.
Abstract Prior entrepreneurial network literature has primarily examined how entrepreneurs’ networking efforts facilitate interorganizational exchanges, while giving little attention to the agency of their contacts. In this study, we investigate how contacts’ intra‐organizational status shapes their actions of referring entrepreneurs to their ...
Xi Chen, Jiaosha Chen, Jin Chen, Ruining Cao   +3 more
wiley   +1 more source

Varicella-zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line.

PLoS ONE, 2013
Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates ...
Peter G E Kennedy, Paul Montague, Fiona Scott, Esther Grinfeld, G H Ashrafi, Judith Breuer, Edward G Rowan   +6 more
doaj   +1 more source

Effectiveness and Tolerability of Topical Amitriptyline 10% Plus Lidocaine 2% Gel in Adults With Post‐Traumatic Trigeminal Neuropathic Pain: A Real‐World Evidence Study

Journal of Oral Rehabilitation, EarlyView.
A compounded amitriptyline 10% plus lidocaine 2% mucoadhesive gel was associated with substantial pain improvement and favourable tolerability in adults with post‐traumatic trigeminal neuropathic pain (PTNP). These findings support targeted mucosal delivery as a promising practical local option and a potential medication‐sparing strategy, particularly ...
Ashley Lebel, Imen Stambouli, Yves Boucher   +2 more
wiley   +1 more source

Sodium channels enable fast electrical signaling and regulate phagocytosis in the retinal pigment epithelium

BMC Biology, 2019
Background Voltage-gated sodium (Nav) channels have traditionally been considered a trademark of excitable cells. However, recent studies have shown the presence of Nav channels in several non-excitable cells, such as astrocytes and macrophages ...
Julia K. Johansson, Viivi I. Karema-Jokinen, Satu Hakanen, Antti Jylhä, Hannu Uusitalo, Maija Vihinen-Ranta, Heli Skottman, Teemu O. Ihalainen, Soile Nymark   +8 more
doaj   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Inherent fast inactivation particle of Nav channels as a new binding site for a neurotoxin

The EMBO Journal
Neurotoxins derived from animal venoms are indispensable tools for probing the structure and function of voltage-gated sodium (Nav) channels. Utilizing a novel centipede peptide toxin called rpTx1, we show that the “inherent inactivation particle” of Nav
Xi Zhou, Haiyi Chen, Shuijiao Peng, Yuxin Si, Gaoang Wang, Li Yang, Qing Zhou, Minjuan Lu, Qiaoling Xie, Xi He, Meijing Wu, Xin Xiao, Xiaoqing Luo, Xujun Feng, Wenxing Wang, Sen Luo, Yaqi Li, Jiaxin Qin, Minzhi Chen, Qianqian Zhang, Weijun Hu, Songping Liang, Tingjun Hou, Zhonghua Liu   +23 more
doaj   +1 more source

Stac2 genetic deletion alters mouse chromaffin cells’ CaV channel composition, increases membrane excitability and reduces vesicle exocytosis

The Journal of Physiology, EarlyView.
Abstract figure legend Stac2 adaptor protein is expressed in neurons and endocrine cells. Using a global Stac2 knockout mouse model here we investigated the role of endogenous Stac2 in adrenal gland mouse chromaffin cell (MCC) excitability and catecholamine vesicle exocytosis.
Stefanie M. Geisler, Noelia Jacobo‐Piqueras, Tamara Theiner, Ryoichi S. Taguchi, Laura E. Häfele, Marta Campiglio, Petronel Tuluc   +6 more
wiley   +1 more source

Summary report: “SET‐Nav - Integrative policy recommendations” Decarbonization the EU’s Energy System

, 2019
What next steps and priorities for the SET Plan? In October 2018, the Intergovernmental Panel on Climate Change (IPCC) published its special report on the impacts of global warming of 1.5°C above pre‐industrial levels and related global greenhouse gas ...
KIM, Yeong Jae, Bernath, Christiane, Herbst, Andrea, Wilson, Charlie, Olmos, Luis, Heitel, Stephanie, Rehfeldt, Matthias, Sensfuss, Frank, Toth, Borbala, Boitier, Baptiste, Lumbreras, Sara, Fleiter, Tobias, Pedro Crespo del Granado, Welisch, Marijke, Resch, Gustav, Hartner, Michael, Ramos, Andrés, Holz, Franziska, Ansari, Dawud, Kotek, Peter, Fougeyrollas, Arnaud   +20 more
core  

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Evaluering av forskningsprosjektet Karriereveiledning for NAV-brukere i Buskerud [PDF]

, 2019
​Med dette foreligger den endelige rapporten fra evalueringen av forskningsprosjektet om karriereveiledning i Nav Buskerud, som ble gjennomført i tidsperioden fra 1.9. 2016 til 1.9.2019.
Buland, Trond Hallgeir, Mordal, Siri
core