Results 111 to 120 of about 17,731 (225)

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, Volume 183, Issue 15, Page 4344-4363, August 2026.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source

School‐to‐Work Transitions Among Out‐of‐Home Care and Aftercare Experienced Individuals: A Norwegian National Register Study

Child &Family Social Work, Volume 31, Issue 3, Page 1956-1976, August 2026.
ABSTRACT Individuals with child protection service (CPS) experience face increased risks of social exclusion and unemployment. Employment is vital for both financial stability and health. Teenagers in out‐of‐home care (OHC) are particularly vulnerable to unemployment.
Trine Holten, Kirsti Klem Valset
wiley   +1 more source

Strategies used by organizations to scale deep: Lessons from a volunteer navigation intervention. [PDF]

Palliat Care Soc Pract
Puurveen G, Ashford K, Pesut B.
europepmc   +1 more source

Beyond Histamine: Mast Cell‐Neuron Communication in Chronic Pruritic and Pain Disorders

Experimental Dermatology, Volume 35, Issue 8, August 2026.
ABSTRACT Chronic pruritic and cutaneous pain disorders are increasingly recognized as neuroimmune conditions driven by dynamic interactions between immune and sensory systems. While histamine has historically dominated models of mast cell‐mediated itch, accumulating evidence indicates that non‐histaminergic pathways are central to chronic disease.
Tomer Kagan, Gil Yosipovitch
wiley   +1 more source

Voltage-Gated Sodium Channels Regulate the Migration Potential of Human Endometrial Mesenchymal Stem/Stromal Cells in 2D and 3D Culture. [PDF]

Cells
Shamatova M, Shorokhova M, Vassilieva I, Chubinskiy-Nadezhdin V, Sudarikova A.   +4 more
europepmc   +1 more source

Association Between Contact Force and Acute Lesion Effectiveness in Focal Pulsed Field Ablation

Journal of Cardiovascular Electrophysiology, Volume 37, Issue 8, Page 1879-1882, August 2026.
ABSTRACT Introduction Pulsed field ablation (PFA), based on irreversible electroporation, is a non‐thermal modality designed to create myocardial lesions while minimizing collateral injury. The determinants of acute lesion effectiveness in humans remain incompletely understood.
Sara Poggi, Nandor Szegedi, Cheryl Teres, Daniel Scherr, Christian Heeger, Gabor Szeplaki, Benjamin Berte, Alexandra Karsai, Teresa Strisciuglio, Giuseppe Stabile   +9 more
wiley   +1 more source

Long-term inactivation mediated by different FGF-A homologues on heterologously expressed NaV1.2 currents. [PDF]

J Gen Physiol
Lorenzo-Ceballos Y, Martinez-Espinosa PL, Xia XM, Lingle CJ.   +3 more
europepmc   +1 more source

Comparison of Spatio‐Temporal Dispersion Electrogram Ablation and Low Voltage Zone Ablation in Patients With Persistent Atrial Fibrillation

Journal of Cardiovascular Electrophysiology, Volume 37, Issue 8, Page 1837-1845, August 2026.
This study compared STDE‐guided versus LVZ‐guided ablation beyond PVI in 107 persistent AF patients. At 24 months, the AF‐free survival rate was significantly higher in the STDE group (76.3% vs. 58.4%, p=0.027). STDE ablation independently reduced recurrence risk (HR: 0.29, p=0.004), providing superior clinical efficacy over LVZ ablation.
Yutaro Kaneko, Yoshihisa Naruse, Yuki Tokonami, Kazuki Ito, Taro Narumi, Makoto Sano, Yuichiro Maekawa   +6 more
wiley   +1 more source

Structural basis for inhibition of the voltage-gated sodium channel Na_V1.7 by the tarantula toxin HWTX-I. [PDF]

J Biol Chem
Wu H, Wang W, Hu Z, Yin Y, Peng D, Zhou Q, He X, Zhu B, Zhong G, Zhong J, Hao X, Wang Y, Liu Z, Chen M, Wang J, Zhang Y, Zhou X.   +16 more
europepmc   +1 more source

NAV in an international context

, 2010
The NAV-reform is one of the largest coordination-oriented reforms in recent Norwegian public administration history. Following years of debate and negotiation, the government decided to merge two sector organizations with long traditions – the employment and national insurance services - into a new entity called the Norwegian Labour and Welfare ...
Christensen, Tom, Fimreite, Anne Lise
openaire   +1 more source