Results 121 to 130 of about 184,365 (253)

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1385-1396, May 2026.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman   +6 more
wiley   +1 more source

Balloon‐Expandable Versus Self‐Expanding Valves in Low‐Flow, Low‐Gradient Aortic Stenosis: Does Valve Type Matter?

open access: yesCatheterization and Cardiovascular Interventions, Volume 107, Issue 6, Page 1718-1725, May 1, 2026.
ABSTRACT Background The optimal choice between balloon‐expandable (BE) and self‐expanding (SE) transcatheter heart valves (THVs) in patients with low‐flow low‐gradient aortic stenosis (LFLG AS) undergoing transcatheter aortic valve replacement (TAVR) remains unclear.
Nav Warraich   +10 more
wiley   +1 more source

Empirical Anatomical Versus HAFE‐Guided Cardioneuroablation for Vasovagal Syncope: Long‐Term Efficacy and Safety Outcomes

open access: yesClinical Cardiology, Volume 49, Issue 5, May 2026.
EAGC and HAFE‐guided cardioneuroablation achieve equivalent 24‐month syncope‐free survival and similar quality of life improvements. HAFE‐guided ablation significantly reduces procedure time and radiation exposure while maintaining comparable safety, supporting its procedural efficiency for vasovagal syncope.
Bo Zhang   +9 more
wiley   +1 more source

NaV1.7 mRNA and Protein Expression in Resident Neurons of the Human Spinal Dorsal Horn

open access: yesJournal of Comparative Neurology, Volume 534, Issue 5, May 2026.
We identified Nav1.7 mRNA and protein in human spinal cord neurons, a subset of which co‐expressed putative projection neuron markers, TACR1 and GPR83. These neurons relay nociceptive signals from the periphery to the brain. While Nav1.7 loss‐of‐function mutations cause congenital insensitivity to pain, traditionally linked to sensory neurons, our ...
Stephanie Shiers   +9 more
wiley   +1 more source

Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management

open access: yesMedComm, Volume 7, Issue 5, May 2026.
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang   +12 more
wiley   +1 more source

Vecums nav šķērslis [PDF]

open access: yes, 2021
Dagnija Staķe   +2 more
openaire   +1 more source

High‐Resolution Diffusion‐Weighted Imaging With Self‐Gated Self‐Supervised Unrolled Reconstruction

open access: yesMagnetic Resonance in Medicine, Volume 95, Issue 5, Page 2852-2862, May 2026.
ABSTRACT Purpose High‐resolution diffusion‐weighted imaging (DWI) is clinically demanding. The purpose of this work is to develop an efficient self‐supervised algorithm unrolling technique for submillimeter‐resolution DWI. Methods We developed submillimeter DWI acquisition utilizing multi‐band multi‐shot EPI with diffusion shift encoding.
Zhengguo Tan   +4 more
wiley   +1 more source

Irrigation needs and yields of wheat under global warming

open access: yesJournal of Agrometeorology, 2018
S.VENKATARAMAN
doaj   +1 more source

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