Results 91 to 100 of about 5,435 (219)

Compound heterozygosity in sodium channel Nav1.7 in a family with hereditary erythermalgia

Molecular Pain, 2008
Hereditary erythermalgia is a painful and debilitating genetic disorder associated with mutations in voltage-gated sodium channel Nav1.7. We have previously reported a Canadian family segregating erythermalgia consistently with a dominant genetic ...
Lynch Mary E, te Morsche Rene HM, Samuels Mark E, Drenth Joost PH   +3 more
doaj   +1 more source

Expression of voltage-gated sodium channel in primary tumors and corresponding metastases in the Copenhagen rat model of prostate cancer [PDF]

, 2013
Objective: Increasing evidence indicates that prostate cancer (PCa) cells possess voltage-gated sodium channels (VGSCs) and these channels contribute to the metastatic progression of the disease.
Şenay Yıldırım
core   +1 more source

Morpho‐Histo‐Cytological Evaluation of Oral Tissues in Burning Mouth Syndrome: A Systematic Review

Journal of Oral Rehabilitation, Volume 52, Issue 12, Page 2449-2480, December 2025.
This systematic review on Burning Mouth Syndrome (BMS) included 14 studies that examined histological changes. 12 studies used incisional biopsies and 2 used exfoliative cytology. Histology and molecular biology techniques were used to assess morphological, phenotypical and genomic changes in oral tissues, primarily from the tongue.
André Luís Porporatti, Ângela Graciela Deliga Schroder, Ashley Lebel, Nathan Moreau, Annabelle Réaux‐Le Goazigo, Ihsène Taïhi, Heike Rittner, Tara Renton, Yves Boucher   +8 more
wiley   +1 more source

Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7 [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2017
Potent and selective antagonists of the voltage-gated sodium channel NaV1.7 represent a promising avenue for the development of new chronic pain therapies. We generated a small molecule atropisomer quinolone sulfonamide antagonist AMG8379 and a less active enantiomer AMG8380.
Thomas J, Kornecook, Ruoyuan, Yin, Stephen, Altmann, Xuhai, Be, Virginia, Berry, Christopher P, Ilch, Michael, Jarosh, Danielle, Johnson, Josie H, Lee, Sonya G, Lehto, Joseph, Ligutti, Dong, Liu, Jason, Luther, David, Matson, Danny, Ortuno, John, Roberts, Kristin, Taborn, Jinti, Wang, Matthew M, Weiss, Violeta, Yu, Dawn X D, Zhu, Robert T, Fremeau, Bryan D, Moyer   +22 more
openaire   +2 more sources

Behavior of ion channels controlled by electric potential difference and of Toll-type receptors in neuropathic pain pathophysiology

Revista Dor
BACKGROUND AND OBJECTIVES: Neuropathic pain is a severe and refractory medical condition, for which only partially effective treatments are currently available.
André Prato Schmidt, Sérgio Renato Guimarães Schmidt   +1 more
doaj   +1 more source

Guanadinium toxins and their interactions with voltage-gated sodium ion channels [PDF]

, 2017
Guanidinium toxins, such as saxitoxin (STX), tetrodotoxin (TTX) and their analogs, are naturally occurring alkaloids with divergent evolutionary origins and biogeographical distribution, but which share the common chemical feature of guanidinium ...
Cembella, Allan, Duran, Lorena
core   +2 more sources

Neuroblastoma: Anti‐Invasive Effects of Tetracaine In Vitro*

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
Ece Selçuk, David S. Silcock, Amanda Foust, Vicky Bousgouni, Mar Arias‐Garcia, Chris Bakal, Mustafa B. A. Djamgoz, Pinar Uysal‐Onganer   +7 more
wiley   +1 more source

The road to evolution of ProTx2: how to be a subtype-specific inhibition of human Nav1.7

Frontiers in Pharmacology
The human voltage-gated sodium channel Nav1.7 is a widely proven target for analgesic drug studies. ProTx2, a 30-residue polypeptide from Peruvian green tarantula venom, shows high specificity to activity against human Nav1.7, suggesting its potential to
Fan Zhao, Yuanyuan Liu, Yiyu Liu, Qi Ye, Hongtao Yang, Mingze Gui, Yongbo Song   +6 more
doaj   +1 more source

NMR structure of μ-conotoxin GIIIC : leucine 18 induces local repacking of the N-terminus resulting in reduced NaV channel potency [PDF]

, 2018
mu-Conotoxins are potent and highly specific peptide blockers of voltage-gated sodium channels. In this study, the solution structure of mu-conotoxin GIIIC was determined using 2D NMR spectroscopy and simulated annealing calculations.
Adams, David J, Craik, David J, Dash, Thomas S, Durek, Thomas, Finol-Urdaneta, Rocio K, Harvey, Peta J, Hill, Justine M, Kurniawan, Nyoman D, McArthur, Jeffrey R, Van Lysebetten, Dorien   +9 more
core   +1 more source

Temperature dependence of erythromelalgia mutation L858F in sodium channel Nav1.7

Molecular Pain, 2007
Background The disabling chronic pain syndrome erythromelalgia (also termed erythermalgia) is characterized by attacks of burning pain in the extremities induced by warmth. Pharmacological treatment is often ineffective, but the pain can be alleviated by
Rush Anthony M, Lampert Angelika, Han Chongyang, Dib-Hajj Sulayman D, Wang Xiaoliang, Yang Yong, Waxman Stephen G   +6 more
doaj   +1 more source