Results 1 to 10 of about 2,009 (183)

CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons [PDF]

Cells, 2021
Regulation of mitochondrial morphology and motility is critical for neurons, but the exact mechanisms are unclear. Here, we demonstrate that these mechanisms may involve collapsin response mediator protein 2 (CRMP2).
Tatiana Brustovetsky, Rajesh Khanna, Nickolay Brustovetsky   +2 more
exaly   +7 more sources

Involvement of CRMP2 in Regulation of Mitochondrial Morphology and Motility in Huntington’s Disease [PDF]

Cells, 2021
Mitochondrial morphology and motility (mitochondrial dynamics) play a major role in the proper functioning of distant synapses. In Huntington’s disease (HD), mitochondria become fragmented and less motile, but the mechanisms leading to these changes are ...
Tatiana Brustovetsky, Rajesh Khanna, Nickolay Brustovetsky   +2 more
exaly   +8 more sources

Collapsin Response Mediator Protein 2 (CRMP2) Modulates Mitochondrial Oxidative Metabolism in Knock-In AD Mouse Model [PDF]

Cells
We explored how the phosphorylation state of collapsin response mediator protein 2 (CRMP2) influences mitochondrial functions in cultured cortical neurons and cortical synaptic mitochondria isolated from APP-SAA KI mice, a knock-in APP mouse model of ...
Tatiana Brustovetsky, Rajesh Khanna, Nickolay Brustovetsky   +2 more
doaj   +3 more sources

CRMP2 inhibits metastasis formation by impairing ILF3-dependent stabilization of CXCL10 mRNA in breast cancer [PDF]

Cell Death and Disease
Tumor-derived elements contribute to the formation of the pre-metastatic niche (PMN) and facilitate cancer metastasis, but much less is known about the key molecular mechanisms.
Binyan Lin, Mei Luo, Yanqing Zhou, Xin Liu, Qin Zhu, Zebin Weng, Lei Li, Tao Cao, Jing Sun, Dawei Yang, E-Hu Liu   +10 more
doaj   +2 more sources

Baishaoluoshi Decoction Mitigates Post-Stroke Spasticity by Targeting Synaptic Plasticity Through the Nogo-A/NgR Signaling Pathway. [PDF]

Brain Behav
Baishaoluoshi Decoction alleviates post‐stroke spasticity by downregulating inhibitory proteins (Nogo‐A/NgR) in the peri‐infarct brain region and reducing NgR/Olig2 co‐localization in oligodendrocytes, thereby enhancing synaptic plasticity. ABSTRACT Objective: This study systematically investigated the effects and molecular mechanisms of Baishaoluoshi ...
Sun X, Zeng S, Lin S, Wu L, Tang X, Zhu J, Zhang Y, Li L, Chen Z, Deng X, Wu D, Xie L.   +11 more
europepmc   +2 more sources

Isoaspartate formation and irreversible aggregation of collapsin response mediator protein 2: implications for the etiology of epilepsy and age-related cognitive decline [PDF]

Amino Acids
Collapsin response mediator protein 2 (CRMP2) functions in the genesis and activity of neuronal connections in mammalian brain. We previously reported that a protein coincident with CRMP2 on 2D-gels undergoes marked accumulation of abnormal L-isoaspartyl
Jeff X. Zhu, Dana W. Aswad
doaj   +2 more sources

Lanthionine Ketimine Ethyl Ester Induces Proliferation and Maturation and Regulates Calcium Flux in Primary Mouse Oligodendrocyte Progenitor Cells. [PDF]

J Neurosci Res
LKE increased OPC proliferation and maturation. LKE reduced Ca responses to ATP and glutamate, and increased responses to KCl. Similar effects occurred with a peptide that disrupts Collapsin Response Mediator Protein 2 interactions with NMDARs and VGCCs.
Cheli VT, Tumuluri SG, McDonald Z, Denton TT, Dupree JL, Paez PM, Feinstein DL.   +6 more
europepmc   +2 more sources

Collapsin Response Mediator Protein 2 (CRMP2) Modulates Induction of the Mitochondrial Permeability Transition Pore in a Knock-In Mouse Model of Alzheimer’s Disease [PDF]

Cells
Hyperphosphorylated collapsin response mediator protein 2 (CRMP2) is elevated in the cerebral cortex of an APP-SAA knock-in mouse model of Alzheimer’s disease and binds the adenine nucleotide translocase (ANT) in a phosphorylation-dependent manner.
Tatiana Brustovetsky, Rajesh Khanna, Nickolay Brustovetsky   +2 more
doaj   +2 more sources

Differential Regulation of DNA Methylation at the CRMP2 Promoter Region Between the Hippocampus and Prefrontal Cortex in a CUMS Depression Model

Frontiers in Psychiatry, 2020
Current evidence supports the idea that neural plasticity is a potential cause of depression. Abundant studies indicate that CRMP2 has important roles in neural plasticity. Moreover, CRMP2 may contribute to the etiology of depression.
Lihua Yao, Gaohua Wang, Zhongchun Liu
exaly   +3 more sources

From Regeneration Failure to Functional Restoration: Unlocking the Neuronal-Intrinsic Regenerative Capacity as a Therapeutic Frontier for Optic Neuropathy and Glaucoma. [PDF]

CNS Neurosci Ther
Optic neuropathy and glaucoma cause permanent visual deficits via retinal ganglion cell (RGC) loss and axon degeneration, affecting millions worldwide. Current treatments slow disease progression but cannot restore lost vision due to regeneration failure in adult RGCs.
Beard E, El-Bushra S, Kader Z, Sun YJ, Au NPB.   +4 more
europepmc   +2 more sources