Relative Resistance of Cdk5-phosphorylated CRMP2 to Dephosphorylation [PDF]
Journal of Biological Chemistry, 2008 Collapsin response mediator protein 2 (CRMP2) binds to microtubules and regulates axon outgrowth in neurons. This action is regulated by sequential phosphorylation by the kinases cyclin-dependent kinase 5 (Cdk5) and glycogen synthase kinase 3 (GSK3) at sites that are hyperphosphorylated in Alzheimer disease.
Cole, Adam R. +9 more
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Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief [PDF]
Channels, 2019 We have previously reported that the microtubule-associated collapsin response mediator protein 2 (CRMP2) is necessary for the expression of chronic pain. CRMP2 achieves this control of nociceptive signaling by virtue of its ability to regulate voltage-gated calcium and sodium channels. To date, however, no drugs exist that target CRMP2.
Aubin Moutal +6 more
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CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation [PDF]
Neural Plasticity, 2015 Cytoskeleton dynamics are critical phenomena that underpin many fundamental cellular processes. Collapsin response mediator proteins (CRMPs) are highly expressed in the developing nervous system, mediating growth cone guidance, neuronal polarity, and ...
Minghui Tan +7 more
doaj +2 more sources
Autoantibodies Against Collapsin Response Mediator Proteins Associated With Encephalopathy/Myelopathy: A Single-Center Retrospective Study. [PDF]
CNS Neurosci TherThis is a study to assess autoantibodies against CRMPs in a cohort of 400 patients with encephalopathy/myelopathy by CBA and TBA tests. Anti‐CRMPs Abs may indicate immune‐mediated neuronal damage in encephalopathy/myelopathy. ABSTRACT Background Collapsin response mediator protein (CRMP) consists of five subtypes (CRMP1–5), which share high homology ...
Wang D +16 more
europepmc +2 more sources
Bioinformatics Analysis of Persistent Dysregulated Expression of Genes Involved in HCV-Induced Neurological Disorders and Liver Injuries After DAA Treatment Through Weighted Gene Co-Expression Network Analysis. [PDF]
Health Sci RepABSTRACT Background and Aims The molecular processes involved in the progression of neuropsychiatric and liver disorders in some patients who have achieved sustained virologic response after successful DAA treatment are still unclear. To understand these processes, we investigated alterations in the transcription patterns of genes associated with ...
Ghobadi MZ +5 more
europepmc +2 more sources
The Neuroscientist, 2014 Cytoskeletal restructuring is essential for nearly all cellular processes in the developing brain. After cell fate determination, newborn cortical neurons must migrate to their final positions while establishing proper axon-dendrite polarity. Significant progress has recently been made towards understanding the cellular and molecular mechanisms ...
Ip, Jacque P.K. +2 more
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Activity of T-type calcium channels is independent of CRMP2 in sensory neurons [PDF]
Channels, 2019 Amongst the regulators of voltage-gated ion channels is the collapsin response mediator protein 2 (CRMP2). CRMP2 regulation of the activity and trafficking of NaV1.7 voltage-gated sodium channels as well as the N-type (CaV2.2) voltage-gated calcium channel (VGCC) has been reported. On the other hand, CRMP2 does not appear to regulate L- (CaV1.x), P/Q- (
Song Cai +4 more
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Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis [PDF]
Life Science Alliance, 2019 Enhanced carbonyl stress results in neurodevelopmental deficits by affecting microtubule function through the formation of irreversible dysfunctional multimer of carbonylated CRMP2.
Manabu Toyoshima +7 more
doaj +3 more sources
Úloha CRMP2 vo vývoji nervového systému. [PDF]
, 2020 Regulation of axon guidance and pruning of inappropriate synapses is key to development of neural circuits. Secreted semaphorins are integral part of both processes. Collapsin response mediator protein 2 (CRMP2) has been shown to regulate axon guidance by mediating Semaphorin 3A (Sema3A) signaling, however, nothing is known about its role in the ...
Žiak, Jakub
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Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury [PDF]
Molecular Brain, 2020 Effective treatment of high-impact pain patients is one of the major stated goals of the National Pain Strategy in the United States. Identification of new targets and mechanisms underlying neuropathic pain will be critical in developing new target ...
Aubin Moutal +3 more
doaj +3 more sources