Results 31 to 40 of about 2,009 (183)
Effect of lidocaine on cognitively impaired rats: Anti‐inflammatory and antioxidant mechanisms in combination with CRMP2 antiphosphorylation [PDF]
Immunity, Inflammation and Disease, 2023 Objective Studies have shown that lidocaine has antioxidative stress, anti‐inflammatory, and nerve‐protective effects. The current study investigated the effects of lidocaine on cognitive function in rats with cognitive dysfunction. Methods A total of 48
Xiaohong Zheng +3 more
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Frontiers in Cellular Neuroscience, 2014 Aberrant ion channel function has been heralded as a main underlying mechanism driving epilepsy and its symptoms. However, it has become increasingly clear that treatment strategies targeting voltage-gated sodium or calcium channels merely mask the ...
Sarah Marie Wilson +4 more
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Effects of esketamine on depression-like behavior and dendritic spine plasticity in the prefrontal cortex neurons of spared nerve injury-induced depressed mice [PDF]
Brazilian Journal of Medical and Biological ResearchThe present study utilized the spared nerve injury (SNI) to create a mouse model of depression to investigate the impact of esketamine on depressive-like behaviors, on the expression of PSD-95 and CRMP2 proteins, and on changes in neuronal dendritic ...
Bixin Huang +4 more
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Blocking CRMP2 SUMOylation reverses neuropathic pain [PDF]
Molecular Psychiatry, 2017 Collapsin response mediator proteins 1−5 (CRMPs1−5) are a family of cytosolic proteins that coordinate neuronal migration, axonal guidance, dendritic organization, dendritic spine development and synaptic plasticity (reviewed in Khanna et al.1and Quach et al.2).
A, Moutal +5 more
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Protein Phosphatase 2A Facilitates Axonogenesis by Dephosphorylating CRMP2 [PDF]
The Journal of Neuroscience, 2010 Protein phosphatase 2A (PP2A) is indispensable in development, and deficits of PP2A and deterioration of neuronal axons have been observed in several neurodegenerative disorders, but the direct link between PP2A and the neuronal axon development is still missing. Here, we show that PP2A is essential for axon development in transfected rat brain and the
Ling-Qiang, Zhu +6 more
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Cells, 2022 Background: Common demographic risk factors are identified in colorectal cancer (CRC) and type 2 diabetes mellitus (DM), nevertheless, the molecular link and mechanism for CRC-DM comorbidity remain elusive.
Yih-Hsin Chang +17 more
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Frontiers in Molecular Neuroscience, 2020 The dynamic trafficking of AMPA receptors (AMPARs), which enables the endocytosis, recycling, and exocytosis of AMPARs, is crucial for synaptic plasticity. Endophilin2, which directly interacts with the GluA1 subunit of AMPARs, plays an important role in
Jifeng Zhang +9 more
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Frontiers in Immunology, 2022 Background and PurposeAn increasing number of autoimmune encephalitis (AE)-associated autoantibodies have been successfully characterized. However, many cases of AE remain unexplained on account of unknown antibodies.
Kaibiao Xu +13 more
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CRMP2 is necessary for Neurofibromatosis type 1 related pain [PDF]
Channels, 2018 Neurofibromatosis type 1 (NF1) is one of the most common genetic diseases, affecting roughly 1 in 3000 individuals. As a multisystem disorder, it affects cognitive development, as well as bone, nerve and muscle constitution. Peripheral neuropathy in NF1 constitutes a potentially severe clinical complication and is associated with increased morbidity ...
Aubin Moutal +4 more
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Cell specific regulation of NaV1.7 activity and trafficking in rat nodose ganglia neurons
Neurobiology of Pain, 2022 The voltage-gated sodium NaV1.7 channel sets the threshold for electrogenesis. Mutations in the gene encoding human NaV1.7 (SCN9A) cause painful neuropathies or pain insensitivity. In dorsal root ganglion (DRG) neurons, activity and trafficking of NaV1.7
Santiago I. Loya-López +6 more
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