Results 51 to 60 of about 2,009 (183)
Arthritis Research & Therapy, 2022 Background Rheumatoid arthritis patients usually suffer from arthritic chronic pain. However, due to an incomplete understanding of the mechanisms underlying autoimmune disorders, the management of arthritic pain is unsatisfactory.
Yue-Peng Jiang +11 more
doaj +1 more source
Molecular dynamics simulations and in vitro analysis of the CRMP2 thiol switch [PDF]
Molecular BioSystems, 2017 Abstract The collapsin response mediator protein CRMP2 (gene: DPYSL2) is crucial for neuronal development. The homotetrameric CRMP2 complex is regulated via two mechanisms: first by phosphorylation and second by the reduction and oxidation of the Cys504 residues of two adjacent subunits.
Daniel Möller +3 more
openaire +3 more sources
CRMP2–Neurofibromin Interface Drives NF1-related Pain
Neuroscience, 2018 An understudied symptom of the genetic disorder Neurofibromatosis type 1 (NF1) is chronic idiopathic pain. We used targeted editing of Nf1 in rats to provide direct evidence of a causal relationship between neurofibromin, the protein product of the Nf1 gene, and pain responses.
Aubin, Moutal +6 more
openaire +3 more sources
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
ASN Neuro, 2019 We previously showed that treatment with lanthionine ketimine ethyl ester (LKE) reduced disease severity and axonal damage in an experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis and increased neuronal maturation and ...
Aubin Moutal +10 more
doaj +1 more source
Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1
The Journal of Physiology, EarlyView.Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang +2 more
wiley +1 more source
Sodium tungstate has an effect on the CRMP2 protein.
, 2012 An important portion of all spots isolated were identified as CRMP2. (A) Representative ARC 2D gel from treated lean mouse. Insert image shows different CRMP2 proteins. Numbers correspond to identification of CRMP2 by mass spectrometry.
Sílvia Barceló-Batllori (153835) +10 more
core +1 more source
Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice [PDF]
Open Biology, 2019 O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease.
Villo Muha +13 more
doaj +1 more source
A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies
Traffic, Volume 27, Issue 3, September 2026.Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby +3 more
wiley +1 more source
Scientific Reports, 2017 The Platelet Derived Growth Factor (PDGF) family of ligands have well established functions in the induction of cell proliferation and migration during development, tissue homeostasis and interactions between tumours and stroma.
Adil R. Sarhan +6 more
doaj +1 more source