Results 61 to 70 of about 2,009 (183)
Epilepsia Open, Volume 11, Issue 3, Page 895-911, June 2026.Abstract Objective Focal epilepsy is characterized by progressive cortical thinning, particularly within limbic structures; however, whether this atrophy reflects acquired seizure‐induced damage or shared genetic predisposition remains unresolved. Methods We integrated genome‐wide association study (GWAS) summary statistics from the ILAE Consortium ...
Dingyuan Zhang +9 more
wiley +1 more source
Crmp1 And Crmp2 Have Synergistic But Distinct Roles In Dendritic Development
, 2016 Collapsin response mediator protein 2, CRMP2, has been identified as an intracellular signaling mediator for Semaphorin 3A (Sema3A). CRMP2 plays a key role in axon guidance, dendritic morphogenesis, and cell polarization. It has been also implicated in a
Nakamura, Fumio +4 more
core +1 more source
MedComm, Volume 7, Issue 6, June 2026.This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang +8 more
wiley +1 more source
DataSheet_1_GSK3β Interacts With CRMP2 and Notch1 and Controls T-Cell Motility.pdf
, 2021 The trafficking of T-cells through peripheral tissues and into afferent lymphatic vessels is essential for immune surveillance and an adaptive immune response.
Brandon Han Siang Wong (11848970) +6 more
core +1 more source
Chinese Medical Journal, 2017 Background: Collapsin response mediator protein-2 (CRMP2) has been shown to be involved in ischemia/hypoxia (IH) injury. We determined whether CRMP2 modulates ischemic injury in the retinal of Ocular ischemic syndrome (OIS). This study was to explore the
Yu Wang +4 more
doaj +1 more source
Chondroitin Sulfate Proteoglycans in CNS Development and Pathophysiology
Journal of Neuroscience Research, Volume 104, Issue 3, March 2026.Chondroitin sulfate proteoglycans (CSPGs) are critical components of the extracellular matrix in the central nervous system (CNS). In the developing CNS, CSPGs regulate neural precursor cells, neuronal migration, axon guidance, synapse organization, and peri‐neuronal net assembly.
Seyed Mojtaba Hosseini +1 more
wiley +1 more source
, 2023 Collapsin response mediator protein 2 (CRMP2) is a member of a protein family, which is highly involved in neurodevelopment, but most of its members become heavily downregulated in adulthood.
Katarzyna Grycel +21 more
core +1 more source
Annals of the Child Neurology Society, Volume 3, Issue 4, Page 314-323, December 2025.ABSTRACT Background Pathogenic CYFIP2 variants cause developmental and epileptic encephalopathy (DEE), characterized by early‐onset intractable epilepsy and developmental delay. The disease course has not been delineated. Codon Arg87 is a de novo mutational hotspot associated with a severe DEE phenotype via gain‐of‐function mechanisms. Currently, there
Michaela Squire +3 more
wiley +1 more source
GSK3-CRMP2 signaling mediates axonal regeneration induced by Pten knockout [PDF]
Communications Biology, 2019 AbstractKnockout of phosphatase and tensin homolog (PTEN−/−) is neuroprotective and promotes axon regeneration in mature neurons. Elevation of mTOR activity in injured neurons has been proposed as the primary underlying mechanism. Here we demonstrate that PTEN−/− also abrogates the inhibitory activity of GSK3 on collapsin response mediator protein 2 ...
Marco Leibinger +3 more
openaire +2 more sources
, 2012 Collapsin response mediator proteins (CRMPs) are intracellular proteins that mediate signals for several extracellular molecules, such as Semaphorin3A and neurotrophins.
Nakamura, Fumio +6 more
core +1 more source