Results 71 to 80 of about 2,009 (183)

Direct binding of the neurorehabilitation drug edonerpic maleate to CRMP2 demonstrated by NMR spectroscopy

Neuroscience Research
Functional recovery after brain damage, such as stroke, depends on neuronal plasticity that reorganizes synaptic connections in intact brain regions.
Meiro Tanaka, Wataru Ota, Tetsu Arisawa, Koh Takeuchi, Takuya Takahashi   +4 more
doaj   +1 more source

The role of CRMP2 in the nervous system development.

, 2020
Regulation of axon guidance and pruning of inappropriate synapses is key to development of neural circuits. Secreted semaphorins are integral part of both processes.
Žiak, Jakub
core  

Synaptic and Non‐Synaptic Functions of PTPRD: A Receptor Tyrosine Phosphatase at the Crossroads of Neural Circuitry and Metabolism

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
PTPRD (receptor‐type protein tyrosine phosphatase delta) translates extracellular adhesion “codes” into intracellular phosphotyrosine signaling that shapes brain circuits. Alternative inclusion of micro‐exons meA and meB sculpts PTPRD's Ig domain, dictating trans‐synaptic binding to partners such as IL1RAPL1 or IL1RAP and thereby tuning synapse ...
Seoyeong Kim, Jae Jin Shin, Muwon Kang, Yunho Yi, Eunjoon Kim   +4 more
wiley   +1 more source

CRMP2 and voltage-gated ion channels: potential roles in neuropathic pain [PDF]

Neuronal Signaling, 2018
Neuropathic pain represents a significant and mounting burden on patients and society at large. Management of neuropathic pain, however, is both intricate and challenging, exacerbated by the limited quantity and quality of clinically available treatments. On this stage, dysfunctional voltage-gated ion channels, especially the presynaptic N-type voltage-
Chew, Lindsey A., Khanna, Rajesh
openaire   +2 more sources

Figure S1: Purification and site mapping of O-GlcNAc CRMP2 from Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

, 2019
Figure S1: Purification and site mapping of O-GlcNAc CRMP2 (a) CRMP2 purified via ion exchange chromatography was subjected to O-GlcNAc enrichment using CpOGAD298N-GST fusion protein.
Kevin D. Read (165019), Jana Alonso (119713), Simon P. Brooks (7864754), Daan M. F. van Aalten (7864757), Marianne Schimpl (208250), Aneika C. Leney (1615276), Alison D. McNeilly (7864751), Thomas G. McWilliams (5865914), Ritchie Williamson (7864748), Calum Sutherland (383724), Rory J. McCrimmon (7809662), Villo Muha (7864745), Rachel Hills (5865932), Albert J. R. Heck (7258637)   +13 more
core   +1 more source

Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders

Molecular Neurodegeneration, 2011
Background Recent studies suggest that the pathogenic process in neurodegenerative disorders may disrupt mature neuronal circuitries and neurogenesis in the adult brain.
Rockenstein Edward, Achim Cristian L, Trejo-Morales Margarita, Dumaop Wilmar, Patrick Christina, Ruf Rebecca, Crews Leslie, Masliah Eliezer   +7 more
doaj   +1 more source

Glucose Metabolic Reprogramming in Colorectal Cancer: From Mechanisms to Targeted Therapy Approaches

Cancer Medicine, Volume 14, Issue 17, September 2025.
ABSTRACT Background Colorectal cancer (CRC) is one of the most common malignant tumors, and its morbidity ranks third among all cancers, with a trend toward younger patients. Metabolic reprogramming, a unique metabolic mode in tumor cells, is closely related to the occurrence and development of CRC. Numerous studies have confirmed that many genetic and
Runkai Zhou, Fazhi Wang, Jiazhe Wen, Xuefeng Zhou, Yugang Wen   +4 more
wiley   +1 more source

CRMP5 Interacts with Tubulin to Inhibit Neurite Outgrowth, Thereby Modulating the Function of CRMP2

, 2010
International audienceCollapsin response mediator proteins (CRMPs) are involved in signaling of axon guidance and neurite outgrowth during neural development and regeneration.
Auger, Carole, Perrot, Valérie, Sébastien Brot, Brot, Sébastien, Honnorat, Jérôme, Véronique Rogemond, Mahnaz Moradi-Améli, Naura Chounlamountri, Moradi-Ameli, M., Chounlamountri, Naura, Moradi-Améli, Mahnaz, Rogemond, Véronique, Carole Auger, Valérie Perrot, Jérôme Honnorat   +14 more
core   +1 more source

Video_1_GSK3β Interacts With CRMP2 and Notch1 and Controls T-Cell Motility.mp4

, 2021
The trafficking of T-cells through peripheral tissues and into afferent lymphatic vessels is essential for immune surveillance and an adaptive immune response.
Brandon Han Siang Wong (11848970), Nur Syazwani Binte Mohamed Salim (11848976), Navin Kumar Verma (3346955), Amuthavalli Kottaiswamy (11848973), Siu Kwan Sze (230315), Mobashar Hussain Urf Turabe Fazil (11848967), Praseetha Prasannan (4900822)   +6 more
core   +1 more source

Molecular Mechanisms of Chronic Pain and Therapeutic Interventions

MedComm, Volume 6, Issue 8, August 2025.
We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.
Zhen Li, Xing Li, Jieqiong Liu, Rao Sun, Yingze Ye, Hongbing Xiang, Fang Luo, Shiyong Li, Ailin Luo   +8 more
wiley   +1 more source