Results 91 to 100 of about 2,009 (183)
, 2015 Indiana University-Purdue University Indianapolis (IUPUI)The voltage-gated sodium channel Nav1.7 has gained traction as a pain target with recognition that loss-of-function mutations in SCN9A, the gene encoding Nav1.7, are associated with congenital ...
Dustrude, Erik Thomas
core +1 more source
Deciphering the role of sphingosine 1‐phosphate in central nervous system myelination and repair
Journal of Neurochemistry, Volume 169, Issue 1, January 2025.Sphingosine‐1‐phosphate (S1P) signals to a family of five S1P receptors 1–5 (S1PR1–5) coupled with different G proteins. Current studies indicate that S1P exerts differential effects on oligodendrocytes (OLG) and myelin depending on the receptor being activated: promoting the survival of oligodendrocyte precursor cells (OPC) via activating S1PR1 whilst
Fatima Binish, Junhua Xiao
wiley +1 more source
The memory enhancing effect of the APP-derived tripeptide Ac-rER is mediated through CRMP2
, 2011 The diasteromeric (D/L) form of the acetylated tripeptide rER(NH2-D-arg-L-glu-D-arg-COOH), derived from the external domain of amyloid precursor protein, protects against amyloid-b induced memory loss for a passive avoidance task inyoung chicks and ...
Radmila Mileusnic +3 more
core +1 more source
Chinese Medical Journal, 2015 Background: Collapsin response mediator protein-2 (CRMP2), a multifunctional cytosolic protein highly expressed in the brain, is degraded by calpain following traumatic brain injury (TBI), possibly inhibiting posttraumatic neurite regeneration.
Yun Yu +3 more
doaj +1 more source
, 2012 Epileptogenesis following traumatic brain injury (TBI) is likely due to a combination of increased excitability, disinhibition, and increased excitatory connectivity via aberrant axon sprouting.
Wilson, Sarah M. +9 more
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PKCγ-mediated phosphorylation of CRMP2 regulates dendritic outgrowth in cerebellar Purkinje cells [PDF]
, 2021 The signaling protein PKCγ is a major regulator of Purkinje cell development and synaptic function. We have shown previously that increased PKCγ activity impairs dendritic development of cerebellar Purkinje cells. Mutations in the protein kinase Cγ gene (
Winkler, Sabine Celine/SCW
core
, 2022 Additional file 3: Supplement Figure 3. Lack of co-localization between CRMP2 and IBA-1, CRMP2 and GFAP, and the co-localization between CRMP2 and NEUN. A. Representative micrographs showing expression of CRMP2 and IBA-1. B.
Yue-Peng Jiang (11304456) +11 more
core +1 more source
Lacosamide in Migraine: Mechanistic Insights and Emerging Clinical Evidence
Neuropharmacology and TherapyMigraine is a common and disabling neurological disorder that is often difficult to manage, despite treatments such as triptans, non-steroidal anti-inflammatory drugs (NSAIDs), and calcitonin gene-related peptide (CGRP)-targeted therapies. Lacosamide, an
Mehroz Mustafa
doaj +1 more source
Центральные и гормональные механизмы адаптации к десинхронизационному стрессу
Интегративная физиологияНа крысах-самцах линии Wistar создана модель 14-суточной десинхронизации циркадианного ритма. В первой серии исследований изучалось влияние десинхронизации на уровень белка 2, опосредующего активность коллапсина (collapsin-response mediator protein 2 ...
Парвин Асад кызы Зульфугарова +1 more
doaj +5 more sources
Efficacy of (S)-lacosamide in preclinical models of cephalic pain
PAIN Reports, 2016 . Migraine is one of the world's most common neurological disorders. Current acute migraine treatments have suboptimal efficacy, and new therapeutic options are needed.
Aubin Moutal +7 more
doaj +1 more source