Results 101 to 110 of about 2,009 (183)

CRMP2 and its phosphorylation prevent axonal misrouting of the corticospinal tract

Neuroscience Letters
During the development of the central nervous system (CNS), the formation of neural circuits such as the corticospinal tract (CST) is crucial to control voluntary movement and is regulated by axonal guidance mechanisms. In this study, we examined the role of CRMP2 (Collapsin response mediator protein 2) in the formation of CST.
Satohiro Takizawa, Yurika Nakanishi, Yumeno Koga, Yuki Yamazaki, Papachan Kolattukudy, Yoshio Goshima, Toshio Ohshima   +6 more
openaire   +2 more sources

Processing and nuclear localization of CRMP2 during brain development induce neurite outgrowth inhibition.

, 2008
International audienceCollapsin response mediator proteins (CRMPs) are believed to play a crucial role in neuronal differentiation and axonal outgrowth. Among them, CRMP2 mediates axonal guidance by collapsing growth cones during development.
Auger, Carole, Becchi, Michel, Moradi-Améli, Mahnaz, Rogemond, Véronique, Giraudon, Pascale, Belin, Marie-Françoise, Auvergnon, Nathalie, Honnorat, Jérôme   +7 more
core   +1 more source

CRMP2 and CRMP4 Are Differentially Required for Axon Guidance and Growth in Zebrafish Retinal Neurons

Neural Plasticity, 2018
Axons are directed to their correct targets by guidance cues during neurodevelopment. Many axon guidance cues have been discovered; however, much less known is about how the growth cones transduce the extracellular guidance cues to intracellular ...
Zhi-Zhi Liu, Jian Zhu, Chang-Ling Wang, Xin Wang, Ying-Ying Han, Ling-Yan Liu, Hong A. Xu   +6 more
doaj   +1 more source

Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions

Molecular Neurobiology, 2019
Collapsin response mediator proteins (CRMPs) are a family of ubiquitously expressed, homologous phosphoproteins best known for coordinating cytoskeletal formation and regulating cellular division, migration, polarity, and synaptic connection. CRMP2, the most studied of the five family members, is best known for its affinity for tubulin heterodimers and
Aubin Moutal, Katherine A. White, Aude Chefdeville, Rachel N. Laufmann, Peter F. Vitiello, Douglas Feinstein, Jill M. Weimer, Rajesh Khanna   +7 more
openaire   +3 more sources

Can Maternal Autoantibodies Play an Etiological Role in ASD Development?

Neuropsychiatric Disease and Treatment, 2020
Iva Dudova,1 Klara Horackova,2 Michal Hrdlicka,1 Martin Balastik3 1Department of Child Psychiatry, Charles University Second Faculty of Medicine, Prague, Czech Republic; 2Department of Psychiatry, Charles University First Faculty of Medicine, Prague ...
Dudova I, Horackova K, Hrdlicka M, Balastik M   +3 more
doaj  

Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus

Neural Plasticity, 2016
Proper density and morphology of dendritic spines are important for higher brain functions such as learning and memory. However, our knowledge about molecular mechanisms that regulate the　development and maintenance of dendritic spines is limited.
Xiaohua Jin, Kodai Sasamoto, Jun Nagai, Yuki Yamazaki, Kenta Saito, Yoshio Goshima, Takafumi Inoue, Toshio Ohshima   +7 more
doaj   +1 more source

TNF-α mediated upregulation of NaV1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation

Molecular Brain, 2019
Clinical and preclinical studies have shown that patients with Diabetic Neuropathy Pain (DNP) present with increased tumor necrosis factor alpha (TNF-α) serum concentration, whereas studies with diabetic animals have shown that TNF-α induces an increase ...
Flávio Henrique Pequeno de Macedo, Rosária Dias Aires, Esdras Guedes Fonseca, Renata Cristina Mendes Ferreira, Daniel Portela Dias Machado, Lina Chen, Fang-Xiong Zhang, Ivana A. Souza, Virgínia Soares Lemos, Thiago Roberto Lima Romero, Aubin Moutal, Rajesh Khanna, Gerald W. Zamponi, Jader S. Cruz   +13 more
doaj   +1 more source

Participación de la proteína mediadora de respuesta a colapsina 2 (CRMP2) en la migración de células de adenocarcinoma de pulmón [PDF]

, 2015
Oriented migration is the basis of major cellular functions such as developmental morphogenesis, tissue repair and tumor metastasis. During cell migration, microtubules are temporarily captured and stabilized near the actin enriched leading by plus end ...
Morales-Urteaga, X. (Xabier), Rouzaut, A. (Ana)   +1 more
core  

CRMP2 Hyperphosphorylation is Characteristic of Alzheimer's Disease and not a Feature Common to Other Neurodegenerative Diseases

, 2011
Collapsin response mediator protein 2 (CRMP2) is an abundant brain-enriched protein that regulates neurite outgrowth. It is phosphorylated by Cdk5 and GSK3, and these modifications are abnormally high in the brains of Alzheimer's disease (AD) patients ...
Lidy van Aalten, Alessia Usardi, Platt, Bettina, David M.A. Mann, Cole, Adam R., Bedford, Lynn, John Mayer, Howlett, David, Usardi, Alessia, Ritchie Williamson, Sutherland, Calum, David Howlett, Bettina Platt, Williamson, Ritchie, Adam R. Cole, Mann, David M. A., Sutherland, Calum; id_orcid, Mann, David M A, van Aalten, Lidy, Florian Plattner, Plattner, Florian, Lynn Bedford, Calum Sutherland, Mayer, John   +23 more
core   +1 more source

Age-dependent alterations in CRMP2 and CRMP4 protein expression profiles in cat visual cortex

, 2006
We monitored the protein expression profiles of collapsin response mediator protein 2 and 4 (CRMP2 and CRMP4) throughout cat primary visual area 17 at different postnatal ages.
Arckens, Lut, Cnops, Lieselotte, Hu, Tjing-Tjing, Van der Gucht, Estel, Burnat, K.   +4 more
core   +1 more source