Results 41 to 50 of about 2,009 (183)

Effects of CRMP2 DNA Methylation in the Hippocampus on Depressive-Like Behaviors and Cytoskeletal Proteins in Rats

Frontiers in Cellular Neuroscience, 2021
Chronic stress appears to alter DNA methylation and DNA methyltransferases (DNMTs) in brain regions related to emotion. Collapsin response mediator protein-2 (CRMP2) mediates the development of depression by regulating microtubule dynamics. In this study,
Dan Xiang, Siqi Sun, Gaohua Wang, Gaohua Wang, Zhongchun Liu, Zhongchun Liu   +5 more
doaj   +1 more source

The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth

Frontiers in Cellular Neuroscience, 2014
Activity-dependent neurite outgrowth is a highly complex, regulated process with important implications for neuronal circuit remodeling in development as well as in seizure-induced sprouting in epilepsy.
Sarah M Wilson, Aubin eMoutal, Ohannes K Melemedjian, Yuying eWang, Weina eJu, Liberty eFrancois-Moutal, May eKhanna, Rajesh eKhanna   +7 more
doaj   +1 more source

Hierarchical CRMP2 posttranslational modifications control NaV1.7 function [PDF]

Proceedings of the National Academy of Sciences, 2016
SignificanceThe voltage-gated sodium channel NaV1.7 is important for electrogenesis in sensory neurons. Insertion within the membrane is required for function of NaV1.7. However, the mechanisms determining how NaV1.7 is trafficked to neuronal cell membranes are poorly understood. Here, we elucidate a signaling program involving a complex and intriguing
Erik T. Dustrude, Aubin Moutal, Xiaofang Yang, Yuying Wang, May Khanna, Rajesh Khanna   +5 more
openaire   +2 more sources

Probenecid Disrupts a Novel Pannexin 1-Collapsin Response Mediator Protein 2 Interaction and Increases Microtubule Stability

Frontiers in Cellular Neuroscience, 2018
Neurite formation relies on finely-tuned control of the cytoskeleton. Here we identified a novel protein-protein interaction between the ion and metabolite channel protein Pannexin 1 (Panx1) and collapsin response mediator protein 2 (Crmp2), a positive ...
Xiaoxue Xu, Leigh E. Wicki-Stordeur, Juan C. Sanchez-Arias, Mei Liu, Mei Liu, Maria S. Weaver, Catherine S. W. Choi, Leigh A. Swayne, Leigh A. Swayne, Leigh A. Swayne   +9 more
doaj   +1 more source

Extracellular Application of CRMP2 Increases Cytoplasmic Calcium through NMDA Receptors [PDF]

, 2018
Collapsin Response Mediator Protein 2 (CRMP2) is an intracellular protein involved in axon and dendrite growth and specification. In this study, CRMP2 was identified in a conditioned media derived from degenerated sciatic nerves (CM).
Matteo, Lorena Romina, Jeismar Carballo, Rodríguez Durán, Jessica Jenireth, Villegas, Raimundo, Castillo Soto, Francisca Cecilia, Deyanell Hernández, Escalona Hernández, José Leonardo, Hernández, Marianela, Jessica Rodriguez, Domingo Balbi, Liliana Casique, Casique, Liliana, José Leonardo Escalona, Cecilia Castillo, Marines Longart, Balbi, Domingo, Martinez Rozas, Juan Carlos, Raimundo Villegas, Rodríguez, Yuryanni, Juan Carlos Martinez, Lorena Matteo, Carballo, Jeismar, Hernández, Deyanell, Lisbeth García, García, Lisbeth, Héctor Rojas, Rojas, Héctor Gustavo, Marianela Hernández, Longart, Marines, Yuryanni Rodríguez   +29 more
core   +1 more source

Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats

Channels, 2022
The voltage-gated sodium channel isoform NaV1.7 is a critical player in the transmission of nociceptive information. This channel has been heavily implicated in human genetic pain disorders and is a validated pain target.
Jiahe Li, Harrison J. Stratton, Sabina A. Lorca, Peter M. Grace, Rajesh Khanna   +4 more
doaj   +1 more source

Collapsin response mediator protein-2 plays a major protective role in acute axonal degeneration

Neural Regeneration Research, 2017
Axonal degeneration is a key pathological feature in many neurological diseases. It often leads to persistent deficits due to the inability of axons to regenerate in the central nervous system.
Jian-Nan Zhang, Jan C Koch
doaj   +1 more source

Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15

Molecular Brain, 2021
Voltage-gated sodium channels are key players in neuronal excitability and pain signaling. Functional expression of the voltage-gated sodium channel NaV1.7 is under the control of SUMOylated collapsin response mediator protein 2 (CRMP2).
Kimberly Gomez, Dongzhi Ran, Cynthia L. Madura, Aubin Moutal, Rajesh Khanna   +4 more
doaj   +1 more source

CRMP2 derived from cancer associated fibroblasts facilitates progression of ovarian cancer via HIF-1α-glycolysis signaling pathway

Cell Death and Disease, 2022
As the predominant stroma cells of tumor microenvironment (TME), cancer associated fibroblasts (CAFs) are robust tumor player of different malignancies.
Yunfeng Jin, Saiyan Bian, Hui Wang, Jiahang Mo, He Fei, Li Li, Tong Chen, Hua Jiang   +7 more
doaj   +1 more source

Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation [PDF]

, 2018
Though used widely in cancer therapy, paclitaxel only elicits a response in a fraction of patients. A strong determinant of paclitaxel tumor response is the state of microtubule dynamic instability. However, whether the manipulation of this physiological
Gray, NS, Herrero-Gonzalez, Sandra, Ferguson, D, Sethi, R, Rodriguez-Aguayo, C, Lopez-Berestein, G, Pradeep, Sunila, Mangala, LS, Taylor, C, Sethi, Ritika, Jiang, D, Alsaadi, A, Campo, L, Mangala, Lingegowda S., Knapp, S, von Delft, Frank, Myers, KA, Abdulkhaliq Alsaadi, Eli M. Carrami, Ahmed Ashour Ahmed, Kevin A. Myers, Hellner, K, Sandra Herrero-Gonzalez, Sunila Pradeep, Dhar, S, Ritika Sethi, Rodriguez-Aguayo, Cristian, Mangala, Lingegowda S, Donatien Chedom Fotso, Nathanael S. Gray, Taylor, Charlotte, Stefan Knapp, von Delft, F, Cristian Rodriguez-Aguayo, Mannion, David, Chen, Fiona, Wang, M, Bast, RC, Pradeep, S, Campo, Leticia, Ming Wang, Lopez-Berestein, Gabriel, Yau, Christopher; id_orcid, Sood, Anil K., Bast, Robert C., Jiang, Dahai, Fabrizio Miranda, Dahai Jiang, Ahmed, Ahmed Ashour, Lingegowda S. Mangala, Karaminejadranjbar, Mohammed, Anil K. Sood, Leticia Campo, Myers, Kevin A, Charlotte Taylor, Gabriel Lopez-Berestein, Fotso, Donatien Chedom, Yau, C, Wang, Ming, Kenta Masuda, Yau, Christopher, Mannion, D, Myers, Kevin A., Goldsmith, Juliet, Yiyan Zheng, Robert C. Bast, Christopher Yau, Fotso, DC, Miranda, Fabrizio, Dhar, Sunanda, Masuda, Kenta, Karin Hellner, Sunanda Dhar, Ferguson, David, Albukhari, Ashwag, Karaminejadranjbar, M, Sood, AK, Miranda, F, Hellner, Karin, Gray, Nathanael, David Mannion, Gray, Nathanael S, Masuda, K, Fiona Chen, David Ferguson, Bast, Robert C, Sood, Anil K, Zheng, Y, Chen, F, Knapp, Stefan, Goldsmith, J, Ahmed, Ahmed A., Frank von Delft, Ahmed, AA, Juliet Goldsmith, Albukhari, A, Zheng, Yiyan, Alsaadi, Abdulkhaliq, Karaminejadranjbar, Mohammad, Herrero-Gonzalez, S, Ashwag Albukhari   +100 more
core   +1 more source