Results 11 to 20 of about 2,009 (183)

CRMP2 as a Candidate Target to Interfere with Lung Cancer Cell Migration [PDF]

Biomolecules, 2021
Collapsin response mediator protein 2 (CRMP2) is an adaptor protein that adds tubulin dimers to the growing tip of a microtubule. First described in neurons, it is now considered a ubiquitous protein that intervenes in processes such as cytoskeletal ...
Xabier Morales, Rafael Peláez, Saray Garasa, Carlos Ortiz de Solórzano, Ana Rouzaut   +4 more
doaj   +6 more sources

Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain

Neurobiology of Pain (Cambridge, Mass ), 2019
Neuropathic pain results from nerve injuries that cause ectopic firing and increased nociceptive signal transmission due to activation of key membrane receptors and channels.
Aubin Moutal, Shizhen Luo, Tally M Largent-Milnes   +2 more
exaly   +4 more sources

GSK3β Interacts With CRMP2 and Notch1 and Controls T-Cell Motility [PDF]

Frontiers in Immunology, 2021
The trafficking of T-cells through peripheral tissues and into afferent lymphatic vessels is essential for immune surveillance and an adaptive immune response.
Mobashar Hussain Urf Turabe Fazil, Praseetha Prasannan, Brandon Han Siang Wong, Brandon Han Siang Wong, Amuthavalli Kottaiswamy, Nur Syazwani Binte Mohamed Salim, Siu Kwan Sze, Navin Kumar Verma   +7 more
doaj   +6 more sources

Trio and CRMP2 regulate axon branching and Semaphorin3A signaling [PDF]

Communications Biology
Trio is a neuronally expressed, Rac1- and RhoA-activating RhoGEF, that is required for neurodevelopment. Mutations affecting the Rac1-activating GEF domain of Trio are associated with profound neurodevelopmental delay and Trio knock-out is embryonic ...
Erin Fingleton, Alexandra Lombardo, Sehoon Won, Kai Chang, Yan Li, Katherine W. Roche   +5 more
doaj   +5 more sources

CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer’s Disease

Cells, 2023
Mitochondrial bioenergetics and dynamics (alterations in morphology and motility of mitochondria) play critical roles in neuronal reactions to varying energy requirements in health and disease.
Tatiana Brustovetsky, Rajesh Khanna, Nickolay Brustovetsky   +2 more
doaj   +5 more sources

Structural Insights into the Altering Function of CRMP2 by Phosphorylation [PDF]

Cell Structure and Function, 2018
Collapsin response mediator protein 2 (CRMP2) regulates neuronal polarity by controlling microtubule dynamics. CRMP2 activity is regulated by semaphorin-induced phosphorylation at the C-terminal tail domain. Unphosphorylated CRMP2 induces effective axonal microtubule formation to give the axonal characteristics to a neurite, whereas phosphorylated ...
Sumi, Takuya, Imasaki, Tsuyoshi, Aoki, Mari, Sakai, Naoki, Nitta, Eriko, Shirouzu, Mikako, Nitta, Ryo   +6 more
core   +5 more sources

Implication of Adipogenesis-Coupled CRMP2 Functional Profile in Metabolic Homeostasis and Imbalance

Biomedicines, 2022
Our previous studies demonstrated that collapsin response mediator protein 2 (CRMP2) is associated with obesity and, in addition, that hyperglycemia-suppressed CRMP2 augments malignant traits of colorectal cancer and is associated with advanced tumor ...
Yih-Hsin Chang, Shu-Wen Chang, Wei-Ting Hsu, Ching-Ping Yang, Yu-Li Lo, Chun-Jung Chen, Hui-Fang Tsai, Ming-Yuh Shiau   +7 more
doaj   +2 more sources

Structural basis for CRMP2-induced axonal microtubule formation [PDF]

Scientific Reports, 2017
AbstractMicrotubule associated protein Collapsin response mediator protein 2 (CRMP2) regulates neuronal polarity in developing neurons through interactions with tubulins or microtubules. However, how CRMP2 promotes axonal formation by affecting microtubule behavior remains unknown.
Shinsuke Niwa, Fumio Nakamura, Yuri Tomabechi, Mari Aoki, Hideki Shigematsu, Takashi Matsumoto, Atsushi Yamagata, Shuya Fukai, Nobutaka Hirokawa, Yoshio Goshima, Mikako Shirouzu, Ryo Nitta   +11 more
openaire   +4 more sources

Dissecting the role of the CRMP2–neurofibromin complex on pain behaviors [PDF]

Pain, 2017
AbstractNeurofibromatosis type 1 (NF1), a genetic disorder linked to inactivating mutations or a homozygous deletion of theNf1gene, is characterized by tumorigenesis, cognitive dysfunction, seizures, migraine, and pain. Omic studies on human NF1 tissues identified an increase in the expression of collapsin response mediator protein 2 (CRMP2), a ...
Moutal, Aubin, Wang, Yue, Yang, Xiaofang, Ji, Yingshi, Luo, Shizhen, Dorame, Angie, Bellampalli, Shreya S., Chew, Lindsey A., Cai, Song, Dustrude, Erik T., Keener, James E., Marty, Michael T., Vanderah, Todd W., Khanna, Rajesh   +13 more
openaire   +3 more sources

Figure S2: Site-specific O-GlcNAc-CRMP2 antibody (OG-CRMP2) recognises Ser517 O-GlcNAcylated CRMP2 in vitro and in vivo.; Figure S3 from Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

, 2019
Figure S2: Site-specific O-GlcNAc-CRMP2 antibody (OG-CRMP2) recognises Ser517 O-GlcNAcylated CRMP2 in vitro and in vivo. (a) Western blot on in vitro glycosylated recombinant CRMP2 using the OG-CRMP2 antibody. Lack of signal on non-O-GlcNAcylated and Ser517Ala CRMP2 samples indicates that the antibody is specific. (b) Western blot on mouse brain lysate
Muha, Villo, Williamson, Ritchie, Hills, Rachel, McNeilly, Alison D., McWilliams, Thomas G., Alonso, Jana, Schimpl, Marianne, Leney, Aneika C., Heck, Albert J. R., Sutherland, Calum, Read, Kevin D., McCrimmon, Rory J., Brooks, Simon P., van Aalten, Daan M. F.   +13 more
openaire   +2 more sources