Results 101 to 110 of about 5,435 (219)

Vector‐mediated release of GABA attenuates pain‐related behaviors and reduces Na V 1.7 in DRG neurons [PDF]

, 2011
Pain is a common and debilitating accompaniment of neuropathy that occurs as a complication of diabetes. In the current study, we examined the effect of continuous release of gamma amino butyric acid (GABA), achieved by gene transfer of glutamic acid ...
Baron, Black, Castro-Lopes, Castro-Lopes, Chattopadhyay, Chattopadhyay, Coull, Cox, Cummins, David J. Finkl, Devor, Dib-Hajj, Dirig, Drenth, Eaton, Ekberg, Engle, Finnerup, Glorioso, Goss, Goss, Hao, Hao, Hao, Hargreaves, Hong, Hong, Hwang, Ibuki, Jolivalt, Lai, Lee, Liu, Liu, Malcangio, Malcangio, Mantyh, Marina Mata, Mata, Misawa, Moore, Munmun Chattopadhyay, Ong, Randall, Rho, Robinson, Shibuya, Smith, Sukhotinsky, Tavakoli, Wilson-Gerwing, Wolfe, Wolfe, Wolfe, Yang, Zhang   +55 more
core   +1 more source

Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?

Advanced Biology, Volume 9, Issue 10, October 2025.
Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez, Hao Zhang, Dhananjay Sah, Juan P. Cata   +3 more
wiley   +1 more source

The Cardiac Sodium Channel Safety Profile of Cenobamate at Therapeutic Concentrations: In Vitro Analyses

Clinical and Translational Science, Volume 18, Issue 10, October 2025.
ABSTRACT The US Food and Drug Administration (FDA) issued a Drug Safety Communication for the antiseizure drug lamotrigine (Lamictal), warning of the risk of QRS prolongation and cardiac arrhythmias. The FDA also requested that other antiseizure medications with a similar mechanism of action (e.g., block of neuronal sodium channels), including ...
William J. Crumb Jr, Susan M. Melnick, Kelli J. Glenn   +2 more
wiley   +1 more source

Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes NaV1.9, NaV1.7 and NaV1.1

Marine Drugs, 2017
Ciguatoxins (CTXs) are marine toxins that cause ciguatera fish poisoning, a debilitating disease dominated by sensory and neurological disturbances that include cold allodynia and various painful symptoms as well as long-lasting pruritus.
Filip Touska, Simon Sattler, Philipp Malsch, Richard J. Lewis, Peter W. Reeh, Katharina Zimmermann   +5 more
doaj   +1 more source

Contusive spinal cord injury causes Nav1.8 dysfunction to upregulate small sensory neuron excitability

The Journal of Physiology, Volume 603, Issue 19, Page 5613-5628, October 1, 2025.
Abstract figure legend Contusive SCI significantly dysregulated excitability of small DRG neurons by enhancing Nav1.8 function. SCI‐induced hyperexcitability was partially reversed by ZL0177, a small compound disrupting FHF interaction with Nav1.8 and Nav1.9.
Yucheng Xiao, Yanling Pan, Naikui Liu, Theodore R. Cummins   +3 more
wiley   +1 more source

The Nav channel bench series: Plasmid preparation

MethodsX, 2014
Research involving recombinant voltage-gated sodium (Nav) channels has unique challenges. Multiple factors contribute, but undoubtedly at the top of the list is these channels’ DNA instability.
Daniel H. Feldman, Christoph Lossin
doaj   +1 more source

Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons. [PDF]

, 2017
Nociceptors are a subpopulation of dorsal root ganglia (DRG) neurons that detect noxious stimuli and signal pain. Veratridine (VTD) is a voltage-gated sodium channel (VGSC) modifier that is used as an "agonist" in functional screens for VGSC blockers ...
A Rambourg, A Wada, AA Harper, AJ Ren, C Lewis, C Virginio, CC Chen, CE Paulsen, CJ Liu, D Usoskin, DJ Cavanaugh, E Sigel, EJ Bradbury, G Collo, G Romey, J Lai, JA Verheugen, JL Biedler, JN Wood, JP Felix, JY Lou, KJ Farrag, L Djouhri, M Stevens, ME Barabas, R Schmidt, RP Seal, RW Teichert, RW Teichert, S Barnes, S Onizuka, SE Jordt, SG Lu, SG Waxman, SN Lawson, SN Lawson, T Hulsen, W Ulbricht, W Ulbricht, WD Snider, Z Cao   +40 more
core   +1 more source

A Conceptual Review of Naturally Occurring Toxins and Venoms as Peptide Blockers to Combat Chronic Low Back Pain

JOR SPINE, Volume 8, Issue 3, September 2025.
This review explores the therapeutic potential of naturally occurring venom‐derived peptides, particularly from reptiles and insects, as novel calcium channel blockers for managing chronic low back pain caused by intervertebral disc degeneration.
James Melrose, Stone Sima, Neha Chopra, Ashish Diwan, Zi Gu   +4 more
wiley   +1 more source

Reversal of Peripheral Neuropathic Pain by the Small-Molecule Natural Product Narirutin via Block of Na_v1.7 Voltage-Gated Sodium Channel. [PDF]

Int J Mol Sci, 2022
Yang H, Shan Z, Guo W, Wang Y, Cai S, Li F, Huang Q, Liu JA, Cheung CW, Cai S.   +9 more
europepmc   +1 more source

Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons [PDF]

, 2015
BACKGROUND: Increased electrical activity in peripheral sensory neurons including dorsal root ganglia (DRG) and trigeminal ganglia neurons is an important mechanism underlying pain.
Barbosa, Cindy, Cummins, Theodore R., Patel, Reesha R., Strong, Judith A., Tan, Zhi-Yong, Vasko, Michael R., Wang, Ruizhong, Xie, Wenrui, Zhang, Jun-Ming   +8 more
core   +1 more source