Results 111 to 120 of about 5,435 (219)

Functional Properties and Toxin Pharmacology of a Dorsal Root Ganglion Sodium Channel Viewed through its Voltage Sensors [PDF]

, 2013
The voltage-activated sodium (Nav) channel Nav1.9 is expressed in dorsal root ganglion (DRG) neurons where it is believed to play an important role in nociception.
Bean, Bruce Palmer, Bosmans, Frank, Martin-Eauclaire, Marie-France, Puopolo, Michelino, Swartz, Kenton J.   +4 more
core   +1 more source

Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform Na_V1.7

Journal of Medicinal Chemistry, 2019
Voltage-gated sodium ion channel subtype 1.7 (NaV1.7) is a high interest target for the discovery of non-opioid analgesics. Compelling evidence from human genetic data, particularly the finding that persons lacking functional NaV1.7 are insensitive to pain, has spurred considerable effort to develop selective inhibitors of this Na+ ion channel target ...
John V. Mulcahy, Hassan Pajouhesh, Jacob T. Beckley, Anton Delwig, J. Du Bois, John C. Hunter   +5 more
openaire   +3 more sources

Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances [PDF]

, 2018
Synthetic pyrethroid insecticides were introduced into widespread use for the control of insect pests and disease vectors more than three decades ago.
Soderlund, David
core  

Voltage-gated sodium channel expression in mouse DRG after SNI leads to re-evaluation of projections of injured fibers. [PDF]

, 2014
BACKGROUND: Dysregulation of voltage-gated sodium channels (Na(v)s) is believed to play a major role in nerve fiber hyperexcitability associated with neuropathic pain.
Decosterd, I., Laedermann, C.J., Pertin, M., Suter, M.R.   +3 more
core   +1 more source

Bone marrow mesenchymal stem cells attenuate pain and modulate peripheral sodium channel activity in a rat model of complex regional pain syndrome type I

Cell Transplantation
Complex Regional Pain Syndrome Type I (CRPS-I) is a chronic neuropathic pain disorder characterized by peripheral nerve hyperexcitability and altered nociceptive signaling.
Yuge Jiang, Kaikai Guo, Yi Liu, Longhe Xu   +3 more
doaj   +1 more source

Context dependent roles of FGF13B-NaV1.7 interaction in pain signaling

Neurobiology of Pain
Voltage-gated sodium channels, such as NaV1.7, serve as pivotal regulators of sensory neuron excitability and nociception. While gain- and loss-of-function mutations in SCN9A cause inherited pain syndromes or congenital insensitivity to pain, the ...
Erick J. Rodríguez-Palma, Samantha Perez-Miller, Kimberly Gomez, Rajesh Khanna   +3 more
doaj   +1 more source

Functional confirmation that the R1488* variant in SCN9A results in complete loss-of-function of Nav1.7

BMC Medical Genetics, 2018
Background Individuals with an extremely rare inherited condition, termed Congenital Insensitivity to Pain (CIP), do not feel pain in response to noxious stimuli.
Wen He, Gareth T. Young, Baohong Zhang, Peter J. Cox, Lily Ting-Yin Cho, Sally John, Sara A. Paciga, Linda S. Wood, Nicolas Danziger, Serena Scollen, Ciara Vangjeli   +10 more
doaj   +1 more source

α-lipoic acid suppresses neuronal excitability and attenuates colonic hypersensitivity to colorectal distention in diabetic rats

Journal of Pain Research, 2017
Yan Sun,1,* Pan-Pan Yang,1,* Zhen-Yuan Song,2 Yu Feng,1 Duan-Min Hu,1 Ji Hu,1 Guang-Yin Xu,3 Hong-Hong Zhang1,3 1Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of ...
Sun Y, Yang PP, Song ZY, Feng Y, Hu DM, Hu J, Xu GY, Zhang HH   +7 more
doaj  

Conservation of alternative splicing in sodium channels reveals evolutionary focus on release from inactivation and structural insights into gating [PDF]

, 2017
Voltage-gated sodium channels are critical for neuronal activity, and highly intolerant to variation. Even mutations that cause subtle changes in the activity these channels are sufficient to cause devastating inherited neurological diseases, such as ...
Liavas, A, Lignani, G, Schorge, S
core   +1 more source

Dendritikus sejt altípusok együttműködése fiziológiás és kóros állapotban = The interplay of dendritic cell subtypes in health and disease [PDF]

, 2011
A dendritikus sejtek (DC) az immunfolyamatok fontos irányítói, melyek alapvető szerepet játszanak a központi és perifériás tolerancia és a gyulladásos folyamatok kiváltásában, fenntartásában és szabályozásában.
Benkő, Szilvia, Bácsi, Attila, Gogolák, Péter, Kis-Tóth (Ludányi), Katalin, Lányi, Árpád, Rajnavölgyi, Éva, Réthi, Bence, Szabó, Attila, Varga, Alíz, Veréb, Zoltán   +9 more
core