Results 121 to 130 of about 5,435 (219)
Calmodulin Recognition of Voltage-Gated Sodium Channels NaV1.1, NaV1.4 and NaV1.7 [PDF]
Biophysical Journal, 2018 Holly M. Isbell +4 more
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Genetic Variants in the SCN9A Gene are Detected in a Minority of Erythromelalgia Patients
Acta Dermato-VenereologicaGain-of-function variants in the voltage-gated sodium channel Nav1.7, encoded by the SCN9A gene, have previously been identified in patients with erythromelalgia, a clinical diagnosis defined by intermittent attacks of painful, hot, swollen, and red skin,
Mari Skystad Kvernebo +6 more
doaj +1 more source
Enzymes are reported to catalyze reactions by generating electric fields that promote the evolution of the reaction in the active site. Although seldom used outside enzymatic catalysis, electrostatic preorganization theory and the language of electric fields can be generalized to other biological macromolecules.
Yi Zheng +2 more
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eLifeNociceptive sensory neurons convey pain-related signals to the CNS using action potentials. Loss-of-function mutations in the voltage-gated sodium channel NaV1.7 cause insensitivity to pain (presumably by reducing nociceptor excitability) but clinical ...
Yu-Feng Xie +3 more
doaj +1 more source
Mediators of Inflammation, 2018 Dexmedetomidine, an α2-adrenoceptor agonist, is widely used as a sedative and analgesic agent in a number of clinical applications. However, little is known about the mechanism by which it exerts its analgesic effects on the trigeminal system.
Sang-Taek Im +5 more
doaj +1 more source
Structure-based assessment of disease-related mutations in human voltage-gated sodium channels
Protein & Cell, 2017 Voltage-gated sodium (Nav) channels are essential for the rapid upstroke of action potentials and the propagation of electrical signals in nerves and muscles. Defects of Nav channels are associated with a variety of channelopathies.
Weiyun Huang +3 more
doaj +1 more source
FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons [PDF]
, 2016 Nav1.6 and Nav1.6-mediated resurgent currents have been implicated in several pain pathologies. However, our knowledge of how fast resurgent currents are modulated in neurons is limited.
Barbosa, Cindy +6 more
core +1 more source
Research Progress of Voltage-Gated Sodium Channel Nav1.7 in Osteoarthritis
Advances in Clinical Medicine, 2022 openaire +1 more source
, 2022 Abstract: The human TE671 cell line was originally used as a model of medulloblastoma but has since been reassigned as rhabdomyosarcoma. Despite the characterised endogenous expression of voltage-sensitive sodium currents in these cells, the specific voltage-gated sodium channel (VGSC) subtype underlying these currents remains unknown.
Ngum, Neville M. +7 more
openaire
Association of NaV1.8 with lipid rafts in DRG sensory neurons
, 2011 Voltage gated sodium channels (VGSCs) play a key role in the initiation and propagation of action potentials in neuronal cells. NaV1.8 is a Tetrodotoxin resistant VGSC expressed in nociceptors and underlies the majority of sodium currents during action
Pristera, Alessandro +1 more
core +1 more source