Results 11 to 20 of about 5,435 (219)

Molecular determinants of μ-conotoxin KIIIA interaction with the human voltage-gated sodium channel NaV1.7 [PDF]

Frontiers in Pharmacology, 2023
The voltage-gated sodium (NaV) channel subtype NaV1.7 plays a critical role in pain signaling, making it an important drug target. Here we studied the molecular interactions between μ-Conotoxin KIIIA (KIIIA) and the human NaV1.7 channel (hNaV1.7).
Ian H. Kimball, Phuong T. Nguyen, Baldomero M. Olivera, Jon T. Sack, Jon T. Sack, Vladimir Yarov-Yarovoy, Vladimir Yarov-Yarovoy   +6 more
doaj   +5 more sources

Therapeutic targeting of voltage-gated sodium channel NaV1.7 for cancer metastasis

Frontiers in Pharmacology
This review focuses on the expression and function of voltage-gated sodium channel subtype NaV1.7 in various cancers and explores its impact on the metastasis driving cell functions such as proliferation, migration, and invasiveness.
Piyasuda Pukkanasut, Renata Jaskula-Sztul, Renata Jaskula-Sztul, Juan Carlos Gomora, Sadanandan E. Velu, Sadanandan E. Velu   +5 more
doaj   +3 more sources

Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief [PDF]

Expert Opinion on Therapeutic Targets, 2016
INTRODUCTION: Chronic pain is a massive clinical problem. We discuss the potential of subtype selective sodium channel blockers that may provide analgesia with limited side effects.
Emery, EC, Luiz, AP, Wood, JN
core   +5 more sources

NaV1.6 and NaV1.7 channels are major endogenous voltage-gated sodium channels in ND7/23 cells.

PLoS ONE, 2019
ND7/23 cells are gaining traction as a host model to express peripheral sodium channels such as NaV1.8 and NaV1.9 that have been difficult to express in widely utilized heterologous cells, like CHO and HEK293.
Jisoo Lee, Shinae Kim, Hye-Mi Kim, Hyun Jeong Kim, Frank H Yu   +4 more
doaj   +4 more sources

The para^bss1 Drosophila melanogaster as Model for Chronic Nociception: Insights Into Cannabidiol Analgesic Effects. [PDF]

Eur J Pain
ABSTRACT Background Chronic pain, which is often unrelated to ongoing injury, is poorly understood and difficult to treat. Genetic studies have identified voltage‐gated sodium (Nav) channels, particularly gain‐of‐function mutations such as L858F and R1150W in human NaV1.7, as involved in the development of chronic pain. Methods A chronic pain model was
Malta SM, Correia LIV, Marquez AS, Bernardes LMM, Howland JG, Mendes-Silva AP, Espíndola FS, Ueira-Vieira C.   +7 more
europepmc   +2 more sources

Human Dorsal Root Ganglia Neuronal Cell Line to Study Nociceptive Signaling: A New Pipeline for Pain Therapy. [PDF]

FASEB J
The nociceptive properties of differentiated human HD10.6 cells were characterized by multiple approaches (A). Peripheral sensitization was induced within HD10.6 cells in response to an inflammatory cocktail (B), modeling nociceptors in a chronic pain state.
Dochnal SA, Du Y, Bandari D, Franco Malange K, Bryant J, Lemes JBP, Whitford A, Cliffe AR, Mali P, Dore K, Miller YI, Yaksh TL.   +11 more
europepmc   +2 more sources

Veratridine modifies the gating of human voltage-gated sodium channel Nav1.7 [PDF]

Acta Pharmacologica Sinica, 2018
Veratridine is a lipid-soluble neurotoxin derived from plants in the family Liliaceae. It has been broadly investigated for its action as a sodium channel agonist. However, the effects of veratridine on subtypes of sodium channels, especially Nav1.7, remain to be studied.
Xiao-Yu, Zhang, Rui-Yun, Bi, Peng, Zhang, Ye-Hua, Gan   +3 more
openaire   +2 more sources

Phosphorylation of a chronic pain mutation in the voltage-gated sodium channel Nav1.7 increases voltage sensitivity [PDF]

Journal of Biological Chemistry, 2021
The journal of biological chemistry : JBC 296, 100227 (2020).
Clara M. Kerth, Petra Hautvast, Jannis Körner, Angelika Lampert, Jannis E. Meents   +4 more
openaire   +3 more sources

µ-Conotoxins Targeting the Human Voltage-Gated Sodium Channel Subtype NaV1.7

Toxins, 2022
µ-Conotoxins are small, potent, peptide voltage-gated sodium (NaV) channel inhibitors characterised by a conserved cysteine framework. Despite promising in vivo studies indicating analgesic potential of these compounds, selectivity towards the therapeutically relevant subtype NaV1.7 has so far been limited.
Kirsten L. McMahon, Hue N. T. Tran, Jennifer R. Deuis, David J. Craik, Irina Vetter, Christina I. Schroeder   +5 more
openaire   +3 more sources

Varicella-Zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line [PDF]

, 2013
Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates ...
A Vafai, BM Bradley, C Bourdon-Wouters, C Han, D Quan, DH Gilden, DW Wareham, Edward G. Rowan, EM Garry, Esther Grinfeld, Fiona Scott, FS Hasnie, FT Scott, G Ashrafi, G. H. Ashrafi, J Fogh, J Lai, JD Markman, JN Wood, Joseph Charles Glorioso, Judith Breuer, MA Hamza, MH Meisler, MJ Craner, MJ Quinlivan, ML Szpara, N Storey, Paul Montague, Peter G. E. Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PR Kinchington, R Dabby, R Mahalingam, RG Dalziel, RL Finnen, S Schünemann, SG Waxman, SJ Medhurst, SM Fleetwood-Walker, TR Cummins, W Peng, WA Catterall, X Zhou   +44 more
core   +5 more sources