Results 191 to 200 of about 5,435 (219)
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Molecular Pharmacology, 2006
Voltage-gated sodium channels are essential for the propagation of action potentials in nociceptive neurons. Nav1.7 is found in peripheral sensory and sympathetic neurons and involved in short-term and inflammatory pain. Nav1.8 and Nav1.3 are major players in nociception and neuropathic pain, respectively. In our effort to identify isoform-specific and
Chantal, Maertens +5 more
openaire +2 more sources
Voltage-gated sodium channels are essential for the propagation of action potentials in nociceptive neurons. Nav1.7 is found in peripheral sensory and sympathetic neurons and involved in short-term and inflammatory pain. Nav1.8 and Nav1.3 are major players in nociception and neuropathic pain, respectively. In our effort to identify isoform-specific and
Chantal, Maertens +5 more
openaire +2 more sources
Naunyn-Schmiedeberg's Archives of Pharmacology, 2017
Tricyclic antidepressants (TCAs) and duloxetine are used to treat neuropathic pain. However, the mechanisms underlying their analgesic effects remain unclear. Although many investigators have shown inhibitory effects of antidepressants on voltage-gated sodium channels (Nav) as a possible mechanism of analgesia, to our knowledge, no one has compared ...
Takafumi Horishita +10 more
openaire +2 more sources
Tricyclic antidepressants (TCAs) and duloxetine are used to treat neuropathic pain. However, the mechanisms underlying their analgesic effects remain unclear. Although many investigators have shown inhibitory effects of antidepressants on voltage-gated sodium channels (Nav) as a possible mechanism of analgesia, to our knowledge, no one has compared ...
Takafumi Horishita +10 more
openaire +2 more sources
Bioorganic & Medicinal Chemistry Letters, 2014
The voltage gated sodium channel Nav1.7 represents an interesting target for the treatment of pain. Human genetic studies have identified the crucial role of Nav1.7 in pain signaling. Herein, we report the design and synthesis of a novel series of benzenesulfonamide-based Nav1.7 inhibitors. Structural-activity relationship (SAR) studies were undertaken
Shaoyi Sun +11 more
openaire +2 more sources
The voltage gated sodium channel Nav1.7 represents an interesting target for the treatment of pain. Human genetic studies have identified the crucial role of Nav1.7 in pain signaling. Herein, we report the design and synthesis of a novel series of benzenesulfonamide-based Nav1.7 inhibitors. Structural-activity relationship (SAR) studies were undertaken
Shaoyi Sun +11 more
openaire +2 more sources
Structural basis for severe pain caused by mutations in voltage gated sodium channels Nav1.7
Biophysical Journal, 2023Tamer M. Gamal El-Din +2 more
openaire +1 more source
Fundamentals, status and promise of sodium-based batteries
Nature Reviews Materials, 2021Robert E Usiskin +2 more
exaly
F270 ROLE OF VOLTAGE-GATED SODIUM CHANNEL NAV1.7 IN VISCERAL PAIN
European Journal of Pain Supplements, 2011R. González-Cano +6 more
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Recycling of sodium-ion batteries
Nature Reviews Materials, 2023Yun Zhao, Naser Tavajohi Hassan Kiadeh
exaly
Background and Purpose: The human TE671 cell line was originally used as a model of medulloblastoma but has since been reassigned as rhabdomyosarcoma. Despite the characterised endogenous expression of voltage-sensitive sodium currents in these cells, the specific voltage-gated sodium channel (VGSC) subtype underlying these currents remains unknown ...
Neville Ngum +4 more
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Neville Ngum +4 more
openaire +1 more source
Artificial channels for confined mass transport at the sub-nanometre scale
Nature Reviews Materials, 2021Jie Shen, Gong-Ping Liu, Yu Han
exaly
Low-solvation electrolytes for high-voltage sodium-ion batteries
Nature Energy, 2022Yan Jin, Yao-bin Xu, Biwei Xiao
exaly