Results 61 to 70 of about 5,435 (219)

Therapeutic opportunities for targeting cold pain pathways [PDF]

, 2015
Cold pain is a frequent symptom in neuropathic pain. Compared to other pain modalities, such as heat pain, the mechanisms behind physiological and pathological cold pain remain elusive.
Lewis, Richard J., Vetter, Irina, Yin, Kathleen, Zimmermann, Katharina   +3 more
core   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Voltage‐gated sodium channel 1.7 expression decreases in dorsal root ganglia in a spinal nerve ligation neuropathic pain model

Kaohsiung Journal of Medical Sciences, 2019
The role of the voltage‐gated sodium channel 1.7 (Nav1.7) is unclear in models of neuropathic pain induced by nerve injury. In the present study, we measured expression levels of Nav1.7 in two distinct neuropathic pain models: spinal nerve ligation (SNL)
Ming Li, Shao‐Jin Zhang, Lin Yang, Xiao‐Lei Fang, Hao‐Fan Hu, Ming‐Yue Zhao, Lei Li, Yan‐Yan Guo, Jin‐Ping Shao   +8 more
doaj   +1 more source

Sodium channel slow inactivation interferes with open channel block [PDF]

Mutations in the voltage-gated sodium channel Nav1.7 are linked to inherited pain syndromes such as erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD). PEPD mutations impair Nav1.7 fast inactivation and increase persistent currents.
A Kondratiev, A Lampert, A Lampert, A Taddese, AB Klinger, AC Errington, AM Rush, BW Jarecki, C Alzheimer, C Barbosa, C Nau, CC Kuo, EC Emery, IM Raman, IM Raman, J Magistretti, J Silva, JG Hoeijmakers, JH Chancey, JP Drenth, JP O’Reilly, JS Bant, JW Theile, JW Theile, M Eberhardt, M Estacion, M Estacion, PL Sheets, S Hebeisen, SD Dib-Hajj, SY Wang, SY Wang, TM Grieco, TP Harty, TR Cummins, TR Cummins, W Sandtner, X Cheng, X Cheng, X Cheng, Y Chen, Y Chen, Y Liu, ZM Khaliq   +43 more
core   +1 more source

Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia [PDF]

, 2017
Automated patch clamp (APC) technology was first developed at the turn of the millennium. The increased throughput it afforded promised a new paradigm in ion channel recordings: it offered the potential to overcome the time-consuming, low-throughput ...
Alexander, Alexander, Alexander, Alexander, Alexandrou, Arias, Asmild, Bagal, Becker, Bridgland-Taylor, Brinkwirth, Brüggemann, Cao, Castle, Chambard, Chambers, Dale, Danker, Deuis, Dunlop, Dunlop, Enna, Estacion, Fertig, Finkel, Friis, Gilbert, Gillie, Golden, Hamill, Hao, Haraguchi, Haythornthwaite, Ji, Kahle, Kao, Kauthale, Klement, Klint, Knabl, Kornecook, Kumar, Kuryshev, Lepple-Wienhues, Lin, Mathes, Mathes, Mathie, Miller, Milligan, Obergrussberger, Obergrussberger, Papakosta, Payne, Perkel, Sakmann, Sauter, Scheel, Schroeder, Shcherbatko, Shcherbatko, Sorota, Southan, Southan, Spencer, Stannard, Stoelzle, Swensen, Tao, Terstappen, Tibbs, Trivedi, Vasilyev, Windley, Xie, Xu, Xu   +76 more
core   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Analgesia linked to Nav1.7 loss of function requires µ- and δ-opioid receptors [version 1; referees: 2 approved]

Wellcome Open Research, 2018
Background: Functional deletion of the Scn9a (sodium voltage-gated channel alpha subunit 9) gene encoding sodium channel Nav1.7 makes humans and mice pain-free. Opioid signalling contributes to this analgesic state.
Vanessa Pereira, Queensta Millet, Jose Aramburu, Cristina Lopez-Rodriguez, Claire Gaveriaux-Ruff, John N. Wood   +5 more
doaj   +1 more source

Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior [PDF]

, 2006
The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Baker, MD, Dickenson, AH, Foulkes, T, Gerke, V, Lane, T, Matthews, EA, Nassar, MA, Okuse, K, Wood, JN   +8 more
core   +1 more source

Ion channel recordings on an injection-molded polymer chip [PDF]

, 2013
In this paper, we demonstrate recordings of the ion channel activity across the cell membrane in a biological cell by employing the so-called patch clamping technique on an injection-molded polymer microfluidic device.
Christensen, Mette Thylstrup, Christiansen, Thomas Lehrmann, Friis, Søren, Garnæs, Jørgen, Kutchinsky, Jonatan, Matteucci, Marco, Taboryski, Rafael, Tanzi, Simone, Wilson, Sandra   +8 more
core   +1 more source

Actions of tefluthrin on rat Nav1.7 voltage-gated sodium channels expressed in Xenopus oocytes [PDF]

Pesticide Biochemistry and Physiology, 2011
In rats expression of the Na(v)1.7 voltage-gated sodium channel isoform is restricted to the peripheral nervous system and is abundant in the sensory neurons of the dorsal root ganglion. We expressed the rat Na(v)1.7 sodium channel α subunit together with the rat auxiliary β1 and β2 subunits in Xenopus laevis oocytes and assessed the effects of the ...
Jianguo, Tan, David M, Soderlund
openaire   +2 more sources