Results 181 to 190 of about 107,878,294 (207)

Simplified captopril analogues as NDM-1 inhibitors

Bioorganic & Medicinal Chemistry Letters, 2014
Captopril is a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 value of 7.9μM. It is composed of two units: a 3-mercapto-2-methylpropanoyl fragment and a proline residue. In this study, we synthesized simple amide derivatives of 3-mercapto-2-methylpropanoic acid, and then tested them as NDM-1 inhibitors in order to identify the ...
Ningning, Li, Yintong, Xu, Qiang, Xia, Cuigai, Bai, Taiyi, Wang, Lei, Wang, Dingdi, He, Nannan, Xie, Lixin, Li, Jing, Wang, Hong-Gang, Zhou, Feng, Xu, Cheng, Yang, Quan, Zhang, Zheng, Yin, Yu, Guo, Yue, Chen   +16 more
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NDM-1 and the Role of Travel in Its Dissemination

Current Infectious Disease Reports, 2012
Antimicrobial resistance is a growing problem globally. The appearance and spread of bacteria that are resistant to most or all commonly available antibiotics has raised the specter of untreatable bacterial infections. The New Delhi metallo-beta-lactamase-1 (NDM-1) has received wide attention because of the extreme resistance it confers, its presence ...
Mary Elizabeth, Wilson, Lin H, Chen
openaire   +2 more sources

NDM-1 — A Cause for Worldwide Concern

New England Journal of Medicine, 2010
NDM-1 (New Delhi metallo-beta-lactamase 1), a genetic element encoding multiple-resistance genes, has been found in various Enterobacteriaceae, rendering them resistant to nearly all antimicrobial agents. Success in combating antibiotic-resistant superbugs has been limited.
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NDM-1 polymicrobial infections including Vibrio cholerae

The Lancet, 2012
In April, 2011, a 49-year-old British man was admitted to our hospital directly from a fl ight home from India. He presented with extensive electrical burns on his face, neck, left arm, leg, soles, and chest, from an accident in a faulty shower 4 days before while in Bihar, India.
Elizabeth, Darley, Janis, Weeks, Lim, Jones, Victoria, Daniels, Mandy, Wootton, Alasdair, MacGowan, Timothy, Walsh   +6 more
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SP23-3 Characterization of NDM-1

International Journal of Antimicrobial Agents, 2013
indicated that the strain NDM-1-Saitama belonged to sequence type ST42 which had not been reported previously. Complete sequencing and gap closing by PCR demonstrated a 49,441bp IncFII plasmid which bears 53 genes. The plasmid pNDM-1Saitama consists of 22kb backbone and 27kb multi-drug resistant region. Half of the backbone showed 100% perfect match of
openaire   +1 more source

NDM-1: A Local Clone Emerges With Worldwide Aspirations

Future Microbiology, 2011
Evaluation of: Kumarasamy KK, Toleman MA, Walsh TR et al.: Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect. Dis. 10(9), 597-602 (2010). Are bacteria always going to outsmart us? With the emergence of the metallo-β-lactamase bla(NDM-1) gene, it certainly
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Dissemination of NDM-1 – Authors' reply

The Lancet Infectious Diseases, 2012
Walsh, Timothy R, Livermore, David M, Weeks, Janis, Toleman, Mark A   +3 more
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NDM-1

Nursing, 2012
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1,2-Isoselenazol-3(2H)-One Derivatives as NDM-1 Inhibitors Displaying Synergistic Antimicrobial Effects With Meropenem on NDM-1 Producing Clinical Isolates

Bioorganic Chemistry, 2022
Sheng-Biao Wan, Xiaoyang Li, Ximing Xu
exaly  

Polyclonal Dissemination of NDM-1- and NDM-9-Producing Escherichia coli and Klebsiella pneumoniae in French Polynesia.

Antimicrobial Agents and Chemotherapy, 2021
Laurent Dortet, Thierry Naas, Rémy A Bonnin   +2 more
exaly