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Simplified captopril analogues as NDM-1 inhibitors
Bioorganic & Medicinal Chemistry Letters, 2014Captopril is a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 value of 7.9μM. It is composed of two units: a 3-mercapto-2-methylpropanoyl fragment and a proline residue. In this study, we synthesized simple amide derivatives of 3-mercapto-2-methylpropanoic acid, and then tested them as NDM-1 inhibitors in order to identify the ...
Ningning, Li +16 more
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The Dissemination of NDM-1 in Acinetobacter baumannii Strains
Current Microbiology, 2022Acinetobacter baumannii is a common pathogen in hospitals and usually causes bacteremia, pneumonia, meningitis, peritonitis and other diseases. Isolates carried NDM-1 gene can make several antibiotics such as carbapenems and other beta-lactams ineffective. Nowadays, the number of A.
Na, Liu +4 more
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NDM-1 — A Cause for Worldwide Concern
New England Journal of Medicine, 2010NDM-1 (New Delhi metallo-beta-lactamase 1), a genetic element encoding multiple-resistance genes, has been found in various Enterobacteriaceae, rendering them resistant to nearly all antimicrobial agents. Success in combating antibiotic-resistant superbugs has been limited.
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SP23-3 Characterization of NDM-1
International Journal of Antimicrobial Agents, 2013indicated that the strain NDM-1-Saitama belonged to sequence type ST42 which had not been reported previously. Complete sequencing and gap closing by PCR demonstrated a 49,441bp IncFII plasmid which bears 53 genes. The plasmid pNDM-1Saitama consists of 22kb backbone and 27kb multi-drug resistant region. Half of the backbone showed 100% perfect match of
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New Delhi Metallo-β-Lactamase (NDM-1): An Updates
Journal of Chemotherapy, 2011New Delhi metallo-β-lactamase (NDM-1) is a novel broad spectrum carbapenemase with ability to inactivate all β-lactams except aztreonam. However, most of the NDM-1-producers also produce aztreonam hydrolysing-β-lactamases thereby making these pathogens absolutely resistant to all β-lactams.
S, Shakil +7 more
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Dissemination of NDM-1 – Authors' reply
The Lancet Infectious Diseases, 2012Walsh, Timothy R +3 more
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NDM-1: A Local Clone Emerges With Worldwide Aspirations
Future Microbiology, 2011Evaluation of: Kumarasamy KK, Toleman MA, Walsh TR et al.: Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect. Dis. 10(9), 597-602 (2010). Are bacteria always going to outsmart us? With the emergence of the metallo-β-lactamase bla(NDM-1) gene, it certainly
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NDM-1–producing Acinetobacter soli from Taiwan
Diagnostic Microbiology and Infectious Disease, 2014Tsai-Ling, Lauderdale +7 more
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