Results 41 to 50 of about 13,075 (181)

Molecular Cloning and Expression of the Fusion (F) Gene from Newcastle Disease Virus in Escherichia coli: A Platform for Further Studies [PDF]

Archives of Razi Institute
Newcastle disease (ND), is a highly contagious viral disease, affecting most of the avian species. The fusion protein in the ND virus serves as the target for immune response. The goal of this study was to develop the DNA vaccine using a fusion gene from
sahere parvas, Hamid Galehdari, masoudreza seifi abad shapuri, Jamal Fayazi   +3 more
doaj   +1 more source

A recombinant oncolytic Newcastle virus expressing MIP-3α promotes systemic antitumor immunity

Journal for ImmunoTherapy of Cancer, 2020
Background The oncolytic Newcastle disease virus (NDV) is inherently able to trigger the lysis of tumor cells and induce the immunogenic cell death (ICD) of tumor cells and is also an excellent gene-engineering vector. The macrophage inflammatory protein-
Yan Sun, Liming Zhang, Feng-Ying Huang, Jin-Yan Wang, Shu-Zhen Dai, Ying-Ying Lin, Zhuoxuan Lu, Rong Cao, Guang-Hong Tan   +8 more
doaj   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Disentangling direct and indirect genetic pathways to neurodevelopmental risk: brain structure and behavior in a population‐based parent–offspring trio study

Journal of Child Psychology and Psychiatry, EarlyView.
Background Neurodevelopmental disorders (NDDs) are highly heritable, yet the pathways linking parental genetic liability to child outcomes remain poorly understood. Traditional designs cannot easily separate genes transmitted to the child from environmental influences shaped by parental genotypes.
Fin J. E. van Uum, Yllza Xerxa, Alexander Neumann, Jean‐Baptiste Pingault, Charlotte A. M. Cecil, Mina Shahisavandi, Koen Bolhuis, Boglarka Kovacs, Henning Tiemeier, Ryan L. Muetzel, Neeltje E. M. van Haren   +10 more
wiley   +1 more source

Soil remineralization with silicate rock powder: nutrient effects on plant quality and ungulate foraging

Restoration Ecology, EarlyView.
Abstract Introduction Silicate rock powder (SRP), a slow‐release mineral additive, is increasingly used as a potential mitigation measure against soil acidification in natural areas. SRP addition has led to a higher soil base saturation and small increases in soil nutrient availability.
Sylvana Harmsen, Tessa Foxen, Joost J. Vogels, Maaike J. Weijters, Henk Siepel, Jan den Ouden, Evi Bohnen‐Verbaarschot, Patrick A. Jansen   +7 more
wiley   +1 more source

Innovation in Newcastle Disease Virus Vectored Avian Influenza Vaccines

Viruses, 2019
Highly pathogenic avian influenza (HPAI) and Newcastle disease are economically important avian diseases worldwide. Effective vaccination is critical to control these diseases in poultry.
Shin-Hee Kim, Siba K. Samal
doaj   +1 more source

Hemagglutination with Newcastle Disease Virus (NDV)

Experimental Biology and Medicine, 1947
SummaryHemagglutination by Newcastle disease virus (NDV) is markedly affected by temperature. At room temperature the reaction is difficult to read, especially with low dilutions of virus. At 4°C the reaction is easily read and titration end-points are readily determined.At 4°C NDV appears to be adsorbed more completely by and to elute less rapidly ...
openaire   +2 more sources

Characterisation of genotype VII Newcastle disease virus (NDV) isolated from NDV vaccinated chickens, and the efficacy of LaSota and recombinant genotype VII vaccines against challenge with velogenic NDV

Journal of Veterinary Science, 2015
A Newcastle disease virus (NDV) isolate designated IBS002 was isolated from a commercial broiler farm in Malaysia. The virus was characterised as a virulent strain based on the multiple basic amino acid motif of the fusion (F) cleavage site (112)RRRKGF(117) and length of the C-terminus extension of the hemagglutinin-neuraminidase (HN) gene. Furthermore,
Shahrestani, Kiarash Roohani, Tan, Sheau Wei, Yeap, Swee Keong, Ideris, Aini, Bejo, Mohd Hair, Omar, Abdul Rahman   +5 more
openaire   +2 more sources

Preclinical 1H MRS Study of a Porcine Model Shows Evidence and Mechanisms for Acute Neuronal Injury in Neonatal Cardiopulmonary Bypass (CPB) Surgery

Magnetic Resonance in Medicine, Volume 96, Issue 2, Page 557-567, August 2026.
ABSTRACT Purpose Congenital heart disease affects 1% of US births, with some infants requiring cardiothoracic surgery under cardiopulmonary bypass (CPB). Optimal surgical parameters to minimize neuronal injury are unknown. We used serial 1H MRS in a neonatal CPB porcine model to assess acute neuronal damage and associated injury mechanisms.
Aaron Omon, Meng Gu, Ralph Hurd, Kirk Riemer, Frank Hanley, Daniel Spielman   +5 more
wiley   +1 more source