Results 91 to 100 of about 599,165 (331)

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Recurrent Cometary Activity in Near-Earth Object (3552) Don Quixote [PDF]

, 2020
Michael Mommert, Joseph L. Hora, David E. Trilling, N. Biver, Kacper Wierzchoś, Olga Harrington Pinto, Jessica Agarwal, Yoonyoung Kim, Andrew McNeill, Maria Womack, Matthew M. Knight, David Polishook, Nicholas Moskovitz, Michael S. P. Kelley, H. A. Smith   +14 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Near-Earth Objects

Bulletin of the AAS, 2021
Michael Nolan, Patrick Michel, F. Venditti, N. Samarasinha, Seiji Sugita, Mark E. Perry, R. Daly, R. Binzel, C. R. Sanchez‐Vahamonde, M. Devogéle, Erik Asphaug, D. Hickson, Joseph R. Masiero, M. Busch, T. Swindle, M. Brozović, Tracy M. Becker, S. Marshall, A. Virkki, Ying Liao, C. d'Aubigny, H. Kaplan, S. Naidu, Ronald J. Vervack, Jr., J. Noviello, A. Springmann, Paul Abell, Jian-Yang Li, P. Taylor, B. Greenhagen, E. Rívera-Valentin, S. Chesley, L. Zambrano-Marin, Lucy F. Lim, E. Howell, D. DellaGiustina, Y. R. Fernandez, Devanshu Jha   +37 more
semanticscholar   +2 more sources

Earth-approaching asteroids: Populations, origin, and compositional types [PDF]

Origin, physical properties, and discovery history of smaller asteroids are reviewed. They appear to link the main belt objects, namely the comets and meteorites.
Helin, E. F., Shoemaker, E. M.
core   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Near-infrared Spectral Homogeneity of the Didymos System Before and After the DART Impact

The Planetary Science Journal
We spectroscopically characterized the Didymos system, target of the Double Asteroid Redirection Test (DART)/Light Italian Cubesat for Imaging of Asteroids (LICIACube) space mission, close in time to the DART impact event, during six nights between 2022 ...
Simone Ieva, E. Mazzotta Epifani, E. Dotto, V. Petropoulou, J. D. P. Deshapriya, P. H. Hasselmann, G. Poggiali, D. Perna, M. Dall’Ora, A. Lucchetti, M. Pajola, S. L. Ivanovski, A. Rossi, J. R. Brucato, P. Palumbo, V. Della Corte, A. Zinzi, C. A. Thomas, J. de León, T. Kareta, N. Moskovitz, N. L. Chabot, A. S. Rivkin, M. Amoroso, I. Bertini, A. Capannolo, S. Caporali, M. Ceresoli, G. Cremonese, I. Gai, L. Gomez-Casajus, E. Gramigna, G. Impresario, R. Lasagni Manghi, M. Lavagna, M. Lombardo, D. Modenini, S. Pirrotta, P. Tortora, F. Tusberti, M. Zannoni, G. Zanotti   +41 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Development of Radar and Optical Tracking of Near-Earth Asteroids at the University of Tasmania

Remote Sensing
We detail the use of the University of Tasmania’s (UTAS) optical and radio telescopes to conduct observations of near-Earth asteroids from 2021 to 2024.
Oliver James White, Guifré Molera Calvés, Shinji Horiuchi, Phil Edwards, Ed Kruzins, Jon Giorgini, Nick Stacy, Andrew Cole, Chris Phillips, Jamie Stevens, Lance Benner, Edwin Peters   +11 more
doaj   +1 more source

On the ballistic capture of asteroids for resource utilisation [PDF]

, 2011
This paper investigates the concept of capturing in the Earth’s neighbourhood Earth-approaching objects such as asteroids and comets. These objects may provide access to potential resources, as well as be potential scientific mission opportunities.
McInnes, C.R., Sanchez Cuartielles, J.P.
core