Results 91 to 100 of about 584,066 (367)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

HIGH-PRECISION FOLLOW-UP OBSERVATIONS OF NEAR-EARTH OBJECTS

Odessa Astronomical Publications, 2018
Main objective of the study is orbit refinement of Near-Earth Objects (NEOs) as part of the global task of asteroid-cometary hazard. We present the latest results of ongoing high-precision astrometric follow-up observations of NEOs using the Mykolaiv ...
N. V. Maigurova, A. V. Pomazan, A. V. Shulga   +2 more
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Identifying LL Chondrite Near-Earth Asteroids Using LL Chondrite Reflectance Spectra

The Astrophysical Journal Letters
Most near-Earth objects are thought to originate from the collisional fragments of the main asteroid belt. One question that remains to be resolved is the proportion of near-Earth objects sampling the core area material of the parent body to the outer ...
Pengyue Wang, Edward Cloutis, Ye Su, Man-To Hui   +3 more
doaj   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Automated detection of asteroids in real-time with the Spacewatch telescope [PDF]

The Spacewatch telescope on Kitt Peak is being used to survey for near-earth asteroids using a Tektronix TK2048 CCD in scanning mode. We hope to identify suitable low delta v candidates amongst the near-earth asteroid population as possible exploration ...
Gehrels, T., Rabinowitz, David L., Scotti, James Vernon   +2 more
core   +1 more source

Heating of near-Earth objects and meteoroids due to close approaches to the Sun

, 2009
It is known that near-Earth objects (NEOs) during their orbital evolution may often undergo close approaches to the Sun. Indeed it is estimated that up to ~70% of them end their orbital evolution colliding with the Sun.
A. Morbidelli, Bottke, Bottke, Bowell, Brucato, Bus, Carvano, Delbo', Delbo', Emery, Grimm, Harris, Harris, Harris, Harris, Hiroi, Hiroi, Keil, Lagerros, Lim, M. Delbo', M. Lazzarin, Marchi, Marchi, Morbidelli, Mustard, P. Paolicchi, Paolicchi, Rivkin, S. Marchi, Salisbury, Spencer, Stuart, Vilas, Wolters, Zavodny   +35 more
core   +3 more sources

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Gravitational capture opportunites for asteroid retrieval missions [PDF]

, 2012
Asteroids and comets are of strategic importance for science in an effort to uncover the formation, evolution and composition of the Solar System. Near-Earth objects (NEOs) are of particular interest because of its accessibility from Earth, but also ...
Alessi, Elisa Maria, Garcia Yarnoz, Daniel, McInnes, Colin, Sanchez Cuartielles, Joan-Pau   +3 more
core  

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source