Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Near-Fault Tilted Deformation of Buildings Associated with Coseismic Surface Ruptures in the Shenxigou Section, 2008 Mw 7.9 Wenchuan Earthquake, Eastern Tibet [PDF]
LithosphereThe coseismic surface ruptures associated with large earthquakes contribute to severe damage to near-fault buildings through fault deformation. However, previous studies simplified geological conditions and were based mainly on numerical and physical ...
Hao Xue +4 more
doaj +1 more source
Influence of source directivity and site effects of 2003 Tokachi-oki earthquake on the generation of high PGA in the near-fault zones. [PDF]
Sci Rep, 2022 Pavlenko OV.
europepmc +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Unzipping of the Conjugate Fault System During the 2024 Mw7.4 Hualien Earthquake
Geophysical Research LettersOn 2 April 2024, a Mw7.4 earthquake struck Taiwan's eastern coast near Hualien City. The fault responsible for the mainshock remained under debate due to the region's complex plate boundary system and intricate fault interactions.
Liuwei Xu +6 more
doaj +1 more source
Application of Polynomial Rocking Bearings as Seismic Isolation System on Irregular Bridges
Civil and Environmental Science Journal, 2018 Friction Pendulum System (FPS) is one of the conventional sliding isolators which widely used and effectively proved to reduce seismic hazard in far-fault earthquakes.
Krisna Febrian Anugerahputra +2 more
doaj +1 more source
A multilayer model of time dependent deformation following an earthquake on a strike-slip fault [PDF]
A multilayer model of the Earth to calculate finite element of time dependent deformation and stress following an earthquake on a strike slip fault is discussed. The model involves shear properties of an elastic upper lithosphere, a standard viscoelastic
Cohen, S. C.
core +1 more source
Study on characteristic parameters of near-fault response spectrum
IOP Conference Series: Materials Science and Engineering, 2018 883 vertical earthquake records within the fault distance of 100 km were selected to study that whether the vertical design response spectrum characteristic parameter should be also used for the seismic design of engineering structure in near-fault region.
Jiale Li, Hongjing Li, Guangjun Sun
openaire +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Remote SensingThe coseismic deformation field on both sides of the fault, especially the distribution and change characteristics of near-field deformation, not only provides important constraints for the fine inversion of the slip distribution model but also serves as
Yujing Song +6 more
doaj +1 more source