Results 81 to 90 of about 36,590 (291)

Estimation of Near-Fault Strong Ground-Motion

, 2018
Accumulated data of strong ground motions have been providing us very important knowledge about rupture processes of earthquakes, propagation-path, site-amplification effects on ground motion, the relation between ground motion and damage... However, most of the ground motion databases used in the development of ground motion prediction models are ...
openaire   +2 more sources

Research on Near-Fault Problems in Earthquake Engineering

TELKOMNIKA Indonesian Journal of Electrical Engineering, 2012
The state-of-the-art of near-fault problems in earthquake engineering is comprehensive reviewed. Strong ground motions in the near-fault region exhibit several new characteristics, which cause the attentions of both seismologists and engineers who zealously studied these ground motions during the last two deceases.
openaire   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Measuring Earthquakes from Optical Satellite Images [PDF]

, 2000
Système pour l'Observation de la Terre images are used to map ground displacements induced by earthquakes. Deformations (offsets) induced by stereoscopic effect and roll, pitch, and yaw of satellite and detector artifacts are estimated and compensated ...
Avouac, Jean-Philippe, Binet, Renaud, Michel, Rémi, Taboury, Jean, Van Puymbroeck, Nadège   +4 more
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Recent Seismic Activity in the Azores Region [PDF]

, 2008
This seismic activity in the Azores Region is characterized by sequences of low-magnitude events, usually with epicenter off-shore. These seismic sequences are sometimes triggered by larger events, felt by the population, that could produce significant ...
Bezzeghoud, M., Borges, J.F., Buforn, E., Caldeira, B.   +3 more
core  

Spectral-element simulations of long-term fault slip: Effect of low-rigidity layers on earthquake-cycle dynamics [PDF]

, 2011
We develop a spectral element method for the simulation of long-term histories of spontaneous seismic and aseismic slip on faults subjected to tectonic loading.
Ampuero, J.-P., Kaneko, Y., Lapusta, N.
core   +1 more source