Results 31 to 40 of about 53,718 (156)
Novel Drug Design for Treatment of COVID‐19: A Systematic Review of Preclinical Studies
Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2022, Issue 1, 2022., 2022 Background. Since the beginning of the novel coronavirus (SARS‐CoV‐2) disease outbreak, there has been an increasing interest in discovering potential therapeutic agents for this disease. In this regard, we conducted a systematic review through an overview of drug development (in silico, in vitro, and in vivo) for treating COVID‐19. Methods.
Sarah Mousavi +4 more
wiley +1 more source
Разработка и регистрация лекарственных средств, 2022 Introduction. Nowadays, discovery and development of innovative drugs represent a relevant goal for the pharmaceutical market. One of such drugs is N-(5-chloropyridine-2-yl)-2-({4-[ethanimidoyl(methyl)benzoyl}amino)-5-methylbenzamide hydrochloride ...
N. S. Dubovik +6 more
doaj +1 more source
Current Trends on Solid Dispersions: Past, Present, and Future
Advances in Pharmacological and Pharmaceutical Sciences, Volume 2022, Issue 1, 2022., 2022 Solid dispersions have achieved significant interest as an effective means of enhancing the dissolution rate and thus the bioavailability of a range of weakly water‐soluble drugs. Solid dispersions of weakly water‐soluble drugs with water‐soluble carriers have lowered the frequency of these problems and improved dissolution.
Ruba Malkawi +4 more
wiley +1 more source
The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist [PDF]
, 2013 Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the ...
Jackson, Edwin K. +36 more
core +2 more sources
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors
British Journal of Pharmacology, Volume 178, Issue S1, Page S27-S156, October 2021., 2021 The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander +154 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021 Although oxidative stress is considered to be one of the key pathogenic factors in rheumatoid arthritis (RA), there is insufficient knowledge regarding the impact of menopause on redox status in this population. Thus, this study is aimed at assessing the influence of menopause within healthy women and within RA patients as well as the impact of RA in ...
Aleksandra Stojanovic +9 more
wiley +1 more source
Long-Term Consequences of Misdiagnosis of Parathyroid Adenomas in Pediatric Patients. [PDF]
Case Rep PediatrPrimary hyperparathyroidism (PHPT) is rare in children but exhibits a more dynamic course than in adults, often leading to multiorgan complications if diagnosis is delayed. This article aims to highlight diagnostic challenges of parathyroid adenomas in children and discuss associated complications from delayed diagnosis.
Roztoczyńska D +6 more
europepmc +2 more sources
Effect of Hydroxypropyl Methylcellulose and Microcrystalline Cellulose in Design and Optimization of Nebivolol Hydrochloride Immediate Release Tablets by Response Surface Methodology [PDF]
, 2021 The goal of the research is to design and optimize Nebivolol Hydrochloride immediate-release tablet using response surface methodology. Nebivolol Hydrochloride immediate-release tablets used in the treatment of heart attacks, myocardial infarction ...
Jithendra, Chimakurthy +5 more
core +1 more source
Brazilian Journal of Pharmaceutical Sciences, 2020 The objective of this study was to determine specific combination of pharmaceutical excipients that lead to formulation of efficient nebivolol hydrochloride SMEDDS and its subsequent formulation into IR-SET (Immediate release- Self emulsifying tablet ...
Hemangi Ramesh Trivedi +2 more
doaj +1 more source
l-Nebiviololinium chloride dihydrate
Acta Crystallographica Section E, 2008 The hydrochloride salt of chiral l-nebivolol {systematic name: (+)−(R,S,S,S)-bis[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]ammonium chloride dihydrate}, C22H26F2NO4+·Cl−·2H2O, was obtained by chiral liquid ...
Andre Hänsicke +3 more
doaj +1 more source