Results 1 to 10 of about 19,673 (210)

The physicochemical fingerprint of Necator americanus. [PDF]

PLoS Neglected Tropical Diseases, 2017
Necator americanus, a haematophagous hookworm parasite, infects ~10% of the world's population and is considered to be a significant public health risk. Its lifecycle has distinct stages, permitting its successful transit from the skin via the lungs (L3)
Veeren M Chauhan, David J Scurr, Thomas Christie, Gary Telford, Jonathan W Aylott, David I Pritchard   +5 more
doaj   +7 more sources

PCR-RFLP screening of polymorphisms associated with benzimidazole resistance in Necator americanus and Ascaris lumbricoides from different geographical regions in Brazil. [PDF]

PLoS Neglected Tropical Diseases, 2018
Ascaris lumbricoides and Necator americanus are soil-transmitted parasites with global geographic distribution, and they represent some of the most common and neglected infections in the world.
Luciana Werneck Zuccherato, Luis Fernando Furtado, Celi da Silva Medeiros, Carina da Silva Pinheiro, Élida M Rabelo   +4 more
doaj   +5 more sources

Proteomic characterization and comparison of the infective and adult life stage secretomes from Necator americanus and Ancylostoma ceylanicum. [PDF]

PLoS Negl Trop Dis
More than 470 million people globally are infected with the hookworms Ancylostoma ceylanicum and Necator americanus, resulting in an annual loss of 2.1 to 4 million disability-adjusted-life-years.
Wong Y, Rosa BA, Becker L, Camberis M, LeGros G, Zhan B, Bottazzi ME, Fujiwara RT, Ritmejeryte E, Laha T, Chaiyadet S, Taweethavonsawat P, Brindley PJ, Bracken BK, Giacomin PR, Mitreva M, Loukas A.   +16 more
europepmc   +4 more sources

Improving stool sample processing and pyrosequencing for quantifying benzimidazole resistance alleles in Trichuris trichiura and Necator americanus pooled eggs. [PDF]

Parasit Vectors, 2021
There is an urgent need for an extensive evaluation of benzimidazole efficacy in humans. In veterinary science, benzimidazole resistance has been mainly associated with three single-nucleotide polymorphisms (SNPs) in the isotype-1 β-tubulin gene. In this
Gandasegui J, Grau-Pujol B, Cambra-Pelleja M, Escola V, Demontis MA, Cossa A, Jamine JC, Balaña-Fouce R, van Lieshout L, Muñoz J, Martínez-Valladares M, Stopping Transmission of Intestinal Parasites (STOP) Project Consortium.   +11 more
europepmc   +4 more sources

Comprehensive analysis of the secreted proteome of adult Necator americanus hookworms. [PDF]

PLoS Neglected Tropical Diseases, 2020
The human hookworm Necator americanus infects more than 400 million people worldwide, contributing substantially to the poverty in these regions. Adult stage N.
Jayden Logan, Mark S Pearson, Srikanth S Manda, Young-Jun Choi, Matthew Field, Ramon M Eichenberger, Jason Mulvenna, Shivashankar H Nagaraj, Ricardo T Fujiwara, Pedro Gazzinelli-Guimaraes, Lilian Bueno, Vitor Mati, Jeffrey M Bethony, Makedonka Mitreva, Javier Sotillo, Alex Loukas   +15 more
doaj   +3 more sources

The effect of novel aromatic heterocycle substituted aminamidine derivatives on Necator americanus. [PDF]

J Antimicrob Chemother
Background The efficacy of current drugs against hookworms at a single dose is highly variable across regions, age groups and infection intensity. Extensive and repeated use of these drugs also leads to potential drug resistance.
Huo L, Wei Y, Xue J, Jiang B, Yin M, Tao Y, Zhang H, Shen Y.   +7 more
europepmc   +4 more sources

A Functional Comparison of Homopentameric Nicotinic Acetylcholine Receptors (ACR-16) Receptors From Necator americanus and Ancylostoma ceylanicum. [PDF]

Front Mol Neurosci, 2020
Effective control of hookworm infections in humans and animals relies on using a small group of anthelmintics. Many of these drugs target cholinergic ligand-gated ion channels, yet the direct activity of anthelmintics has only been studied in a subset of
Kaji MD, Geary TG, Beech RN.
europepmc   +4 more sources

Development and evaluation of fluorescent recombinase polymerase amplification (RPA)-based method for rapid detection of Necator americanus. [PDF]

PLoS Neglected Tropical Diseases
BackgroundNecator americanus is the predominant species causing hookworm infections in humans. Despite advancements in prevention strategies, mild cases of infection still occur, highlighting the need for improved detection technology.
Jia-Rui Liang, Shu-Ning Yan, Han-Yin Yang, Shuo Yang, Yu-Juan Shen, Le-Le Huo, Yu-Chun Cai, Zi-Ran Mo, Bin Zheng, Bin Xu, Wei Hu   +10 more
doaj   +3 more sources

Necator americanus Ancylostoma Secreted Protein-2 (Na-ASP-2) Binds an Ascaroside (ascr#3) in Its Fatty Acid Binding Site. [PDF]

Front Chem, 2020
During their infective stages, hookworms release excretory-secretory (E-S) products, small molecules, and proteins to help evade and suppress the host's immune system.
El Atab O, Darwiche R, Truax NJ, Schneiter R, Hull KG, Romo D, Asojo OA.   +6 more
europepmc   +4 more sources

Computer-aided identification of potential inhibitors against Necator americanus glutathione S-transferase 3 [PDF]

Informatics in Medicine Unlocked, 2022
Hookworm infection is caused by the blood-feeding hookworm gastrointestinal nematodes. Its harmful effects include anemia and retarded growth and are common in the tropics. A current control method involves the mass drug administration of synthetic drugs,
Samuel K. Kwofie, Seth O. Asiedu, Russell Koranteng, Emelia Quarshie, Elvis K. Tiburu, Whelton A. Miller, III, Michael B. Adinortey, Michael D. Wilson   +7 more
doaj   +3 more sources