Results 191 to 200 of about 34,308 (261)

Plasma Metabolomics of Thrombectomy‐Treated Patients Highlights Metabolic Pathways Underlying Disease and Recovery

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Untargeted plasma metabolomics reveals distinct metabolic signatures distinguishing thrombosis patients with successful vs. failed recovery after recanalization. Altered pathways involving mitochondrial function, lipid metabolism, amino‐acid utilization, and inflammation highlight potential biomarkers and therapeutic targets for monitoring disease ...
Min Cai, Xiangyu Hou, Shilong Deng, Wenxin Shen, Dingzhi Gao, Xinyu Zhang, Siyuan Fan, Yongliang Xia, Yuanlin Ma, Ke Cheng   +9 more
wiley   +1 more source

The challenge of cell death switching in inflammasome-targeted therapies for bacterial and viral infections. [PDF]

Commun Biol
Li Y, Lv D, Xie Q, Qi Y, Qi X.
europepmc   +1 more source

USP43‐mediated deubiquitination of SLC7A11 protects against LPS‐induced acute lung injury by inhibiting ferroptosis

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Ubiquitin‐specific protease 43 (USP43) in up‐regulated during lipopolysaccharide (LPS)‐induced acute lung injury (ALI). USP43 interacts and inhibits the degradation of solute carrier family 7 member 11 (SLC7A11) by removing the K48‐linked ubiquitination of it, thereby suppressing ferroptosis.
Li Zhang, Jutong He, Ming Xu, Bamawa Mwengendi Joël, Guiomar Correia, Xuefeng Zhou, Xinyi Li, Hexiao Tang   +7 more
wiley   +1 more source

Attenuated FTO induces necroptosis of alveolar epithelium via the m⁶A/CYP1B1/ROS/MLKL axis to promote the aggravation of pulmonary emphysema. [PDF]

Redox Biol
Wu M, Wang W, Chen Z, Yang Y, Yan J, Cui Y, Huang P, Zhang F, Tu W, Chen W, Sun R, Zhou Y, Zhu L, Ran P.   +13 more
europepmc   +1 more source

Mex‐3 RNA‐binding family member A limits macrophage ferroptosis‐associated injury linked to the SLC7A11/GPX4 pathway in diabetic atherosclerosis

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Diabetes reduces macrophage MEX3A and aggravates atherosclerotic plaque instability. MEX3A stabilises Slc7a11 and Gpx4 mRNAs to sustain SLC7A11/GPX4 antioxidant defence. MEX3A deficiency promotes macrophage ferroptosis, lipid peroxidation and mitochondrial injury. Ferrostatin‐1 partially attenuates ferroptotic injury and diabetic plaque destabilisation.
Yanpeng Ma, Jing Liu, Yujie Xing, Shuo Pan, Begench H. Annayev, Wei Wu, Xiqiang Wang, Zhongwei Liu   +7 more
wiley   +1 more source

Lactobacillus johnsonii Suppresses Colorectal Cancer in Association With Intestinal Statine Enrichment and Tumor Cell Apoptosis

Food Frontiers, Volume 7, Issue 4, July 2026.
Lactobacillus johnsonii (LJ) demonstrates prophylactic and therapeutic activity against colorectal tumors in AOM/DSS and MC38 murine models. Integrative microbiome, metabolomic, and transcriptomic analyses associate LJ treatment with TNF‐related signaling, apoptotic gene programs, and increased intestinal statine (STA).
Shengwei Chen, LiZhuowen Yan, Jingtao Zeng, Yikun Chen, Xinyuan Zhao, Wei Meng, Jionghan Zhuang, Fengying Chen, Yonglong Guo, A. M. Abd El‐Aty, Xianghong Ju, Shihua Yang   +11 more
wiley   +1 more source

IFN-I Induces Keratinocytes Necroptosis via ZBP1-MLKL Axis in Oral Lichen Planus. [PDF]

Inflammation
Jiang X, Chen J, Yao Y, Lai Y, Yang X, Tang G, Sun L, Wang Y.   +7 more
europepmc   +1 more source

Multiple myeloma: A tale of deregulated transcription factors

HemaSphere, Volume 10, Issue 7, July 2026.
Abstract A comprehensive understanding of the molecular mechanisms underlying multiple myeloma (MM) pathogenesis is essential for developing therapeutic strategies that overcome disease heterogeneity and treatment relapse. In this review, we focus on transcription factors (TFs), key regulators of gene expression that play critical roles in normal ...
Nahia Gómez‐Echarte, Edurne San José‐Enériz, Estíbaliz Urizar‐Compains, Paula Rodriguez‐Otero, Felipe Prósper, Xabier Agirre   +5 more
wiley   +1 more source

Correction: Zhang et al. Construction of a Prognostic and Early Diagnosis Model for LUAD Based on Necroptosis Gene Signature and Exploration of Immunotherapy Potential. <i>Cancers</i> 2022, <i>14</i>, 5153. [PDF]

Cancers (Basel)
Zhang B, Wang Y, Zhou X, Zhang Z, Ju H, Diao X, Wu J, Zhang J.   +7 more
europepmc   +1 more source

Mometasone Furoate Alleviates PM2.5‐Induced Pyroptosis of Nasal Mucosa Cells via Blocking JAK2/STAT3/AIM2 Inflammasome

Immunity, Inflammation and Disease, Volume 14, Issue 7, July 2026.
ABSTRACT Objective Mometasone furoate (MF) is a widely used intranasal corticosteroid for the management of allergic and non‐allergic rhinitis. Recent evidence suggests that its therapeutic efficacy may involve mechanisms beyond traditional anti‐inflammatory actions, including modulation of death in nasal mucosa cells.
Bin Shi, Zhiqi Liu, Ge Le
wiley   +1 more source