Results 171 to 180 of about 34,308 (261)

The RIPK3 Inhibitor GSK872 Attenuates Inflammation and Necroptosis via Modulation of the JNK Signaling Pathway in LPS-Stimulated Microglia. [PDF]

Biomol Ther (Seoul)
Park JS, Kim DY, Kim SE, Hyun JW, Kim HS.   +4 more
europepmc   +1 more source

The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation

American Journal of Hematology, Volume 101, Issue 8, Page 1980-1996, August 2026.
ABSTRACT Allogeneic hematopoietic cell transplantation (allo‐HCT) is an effective treatment for patients with high‐risk hematologic malignancies. Over the last decade, gut microbiota composition during allo‐HCT has been associated with patients' outcomes.
Wenjing Hao, Nicolas Stocker, Béatrice Gaugler, Mohamad Mohty, Florent Malard   +4 more
wiley   +1 more source

Hypoxia Upregulates RIPK1 via the HIF-1α-JAK-STAT Pathway Leading to Astrocyte Necroptosis to Promote Cavitation After Spinal Cord Injury. [PDF]

CNS Neurosci Ther
Bi H, Zhang W, Duan H, Wang C, Shen X, Jiang G, Xue H, Yan R, Xu Y, Zhang Y, Zhao H, He F, Wang Z.   +12 more
europepmc   +1 more source

Selenium‐Containing 1,4‐Naphthoquinone Derivatives Trigger Reactive Oxygen Species and Apoptosis in Triple‐Negative Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Cancer ranks as a leading cause of death worldwide, demanding new affordable therapies. Nature offers a diverse array of bioactive scaffolds, including 1,4‐naphthoquinone, which serves as a precursor for numerous natural and synthetic compounds with potent antitumor properties.
Eduardo Angulo‐Elizari, Asif Raza, Hannah Johnson, Nuria Martínez‐Sáez, Ignacio Encío, Arun K. Sharma, Carmen Sanmartín, Daniel Plano   +7 more
wiley   +1 more source

Identification of human MLKL Cys184 and HSPBP1 Cys201 as novel cellular targets for necroptosis. [PDF]

Cell Death Dis
Shao H, Wu J, Han Q, Xu L, Dai P, Wang R, Li J, Wu W, Hao Y, Hou R, Chai Y, Cheng Z, Wang P, Xue L, Han T, Zhuang C.   +15 more
europepmc   +1 more source

Contact sensitisers activate keratinocytes and induce cytotoxicity via Transient Receptor Potential Ankyrin 1 in allergic contact dermatitis

British Journal of Pharmacology, Volume 183, Issue 16, Page 4610-4627, August 2026.
Abstract Background and Purpose Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease with limited therapeutic options. While neuronal Transient Receptor Potential Ankyrin 1 (TRPA1) has been implicated in ACD, the role of keratinocyte TRPA1 remains unclear.
Areej Jaber, Szabina Horváth, Balázs Zoltán Zsidó, Viktória Kormos, János Konkoly, Csaba Hetényi, Erika Pintér, Ágnes Kemény, Rolland Gyulai   +8 more
wiley   +1 more source

Experimental Models of Autoimmune Hepatitis: Disease Fidelity and Translational Relevance

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Autoimmune hepatitis (AIH) remains difficult to study mechanistically in patients because disease initiation is rarely observed directly, the relevant autoantigens differ across subsets, and clinically meaningful outcomes such as chronic inflammation, fibrosis, relapse, and treatment response evolve over time.
Laura Elisa Buitrago‐Molina, Matthias Hardtke‐Wolenski   +1 more
wiley   +1 more source

Mitochondrial homeostasis imbalance-triggered PANoptosis in traumatic brain and spinal cord injury: from mechanism to therapeutic strategies. [PDF]

Redox Biol
Ye Y, Feng Z, Huang P, Su X, Lu C, Yu Y, Li L, Wang J, Li X.   +8 more
europepmc   +1 more source

Microarray Gene Expression Analysis of Lesional Skin in Canine Vesicular Cutaneous Lupus Erythematosus (VCLE)

Veterinary Dermatology, Volume 37, Issue 4, Page 478-487, August 2026.
Background: Vesicular cutaneous lupus erythematosus (VCLE) is a rare autoimmune disease in dogs and is considered the canine counterpart of human subacute cutaneous lupus erythematosus (SCLE). However, the molecular mechanisms underlying VCLE remain incompletely defined.
Treasa Clifford, Lauren W. Stranahan, Dominique J. Wiener, M. Kelly Keating, Renato Leon, Frane Banovic   +5 more
wiley   +1 more source

Role of Programmed Cell Death Pathways in Mediating Epithelial Wound Healing and Its Defects in Diabetic Corneas. [PDF]

Invest Ophthalmol Vis Sci
Gao N, Yu FX.
europepmc   +1 more source