Results 211 to 220 of about 60,497 (319)

Sublethal necroptosis signaling promotes inflammation and liver cancer.

Immunity, 2023
M. Vucur, A. Ghallab, A. Schneider, Arlind Adili, Mingbo Cheng, M. Castoldi, Michael T Singer, Veronika Büttner, Leonie Keysberg, Lena Küsgens, Marlene S Kohlhepp, B. Görg, S. Gallage, J. E. Barragan Avila, K. Unger, C. Kordes, Anne-Laure Leblond, Wiebke Albrecht, S. Loosen, Carolin Lohr, Markus S Jördens, Anne Babler, Sikander Hayat, David Schumacher, M. T. Koenen, O. Govaere, M. Boekschoten, S. Jörs, C. Villacorta-Martin, V. Mazzaferro, J. Llovet, R. Weiskirchen, Jakob Nikolas Kather, P. Starlinger, M. Trauner, M. Luedde, L. Heij, U. Neumann, V. Keitel, J. Bode, R. Schneider, F. Tacke, B. Levkau, T. Lammers, Georg Fluegen, T. Alexandrov, Amy L. Collins, G. Nelson, F. Oakley, D. Mann, C. Roderburg, T. Longerich, A. Weber, A. Villanueva, A. Samson, James M. Murphy, R. Kramann, F. Geisler, Ivan G. Costa, J. Hengstler, Mathias Heikenwalder, T. Luedde   +61 more
semanticscholar   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Influenza A Virus (H1N1) Infection Induces Ferroptosis to Promote Developmental Injury in Fetal Tissues

Cell Proliferation, EarlyView.
H1N1 infection during pregnancy specifically targets the fetal liver and lungs, triggering immune responses, tissue fibrosis and ferroptosis in parenchymal cells, ultimately leading to adverse pregnancy outcomes, offering insights into managing maternal H1N1 infections and their impact on fetal health.
Yuxi Jiang, Yao Shen, Qiongyin Zhang, Zi Liu, Yuzhen Liu, Jiaojiao Peng, Xuesong Yang, Feng Gao, Xiang‐Hong Ou, Qing‐Yuan Sun, Qiao Zhang, Guang Wang   +11 more
wiley   +1 more source

Mitoxyperilysis: A Novel Cell Death Pathway With Transformative Implications for Organ Pathophysiology and Therapeutic Innovation

Organ Medicine, EarlyView.
Wenhao Shen, Junmei Li, Weifeng Hu
wiley   +1 more source

LCN2‐ACOD1 Signalling Affects the Post‐Injury Regeneration of Skeletal Muscle Through Mediating Ferroptosis

Cell Proliferation, EarlyView.
LCN2 mediates the suppression of C2C12 myoblast proliferation and myotube formation via erastin‐induced ferroptosis. Mechanistically, the LCN2‐ACOD1 axis regulates skeletal muscle growth via mitochondria‐associated ferroptosis, providing a theoretical basis for the prevention and therapy of muscle‐related diseases.
Xiaojing Hao, Hongwei Shi, Di Wu, Rui Liang, Tong Zhao, Wen Sun, Yue Wang, Xiuju Yu, Xiaomao Luo, Yi Yan, Jiayin Lu, Haidong Wang, Juan Wang   +12 more
wiley   +1 more source

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, EarlyView.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

RIPK3-driven phosphorylation of MFN2 orchestrates endoplasmic reticulum-mitochondria interaction and cardiomyocyte stress responses. [PDF]

Redox Biol
Wang Y, Xu T, Li Q, Ye L, Wang P, Wang P, Song Y, Ao X, Wang J, Ding W.   +9 more
europepmc   +1 more source

Prevalence of new‐onset diabetes following COVID‐19 infection: A systematic review and meta‐analysis

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aim To estimate the prevalence of new‐onset diabetes in adults (≥ 18 years) following SARS‐CoV‐2 infection. Materials and Methods This meta‐analysis includes studies written in English that measured the number of adults (≥ 18 years) diagnosed with diabetes following SARS‐CoV‐2 infection.
Jordan N. Keels, Rose D. LaPlante, Christopher S. Lee, Andrew A. Dwyer   +3 more
wiley   +1 more source

vIRA Inhibition of Antiviral Necroptosis and RIPK3 Binding Are Separable Events. [PDF]

Pathogens
Ragan KB, Sridharan H, Stark AS, Ilami K, Fisher AD, Brahms ON, Kaiser WJ, Upton JW.   +7 more
europepmc   +1 more source

The structural, functional, and therapeutic potential of metacaspases in fungi and protozoa

The FEBS Journal, EarlyView.
Metacaspases are Ca2+‐dependent cysteine proteases whose structural characteristics, particularly calcium binding and autocatalytic processing, govern their activation and biological functions. These enzymes differ among microorganisms and regulate their cell cycles, making them excellent targets for drug development.
Ane C. M. Duarte, Mariana N. R. Trujilho, Karolaine S. S. M. Valdivia, Aline F. Araujo, Laura M. C. de Lorena, Vinicius H. de Oliveira, Beatriz V. Pereira, Emilly R. Leme, Wagner A. S. Júdice, Maurício F. M. Machado   +9 more
wiley   +1 more source