Results 241 to 250 of about 60,497 (319)

Molecular mechanisms of necroptosis: an ordered cellular explosion

Nature reviews. Molecular cell biology, 2010
P. Vandenabeele, L. Galluzzi, T. Berghe, G. Kroemer   +3 more
semanticscholar   +1 more source

Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis‐Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu, Peng Wang, Qing‐Hua Shen, Qi‐Xin Guan, Zhi‐Yuan Li, Ying‐Ying Han, Xin‐Yi Zhang, Qing‐Yuan Hu, Cai‐Ping Tan   +8 more
wiley   +1 more source

Synaptotagmin-7 drives stress-induced cardiomyocyte necroptosis via the p53-Bak-mPTP axis. [PDF]

Theranostics
Li J, Wang S, Han Y, Liu J, Li Y, Zhang J, Guo L, Jin Y, Chang J, Liu T, Zhou L, Liu S, Yang G, Zhang S, Cao J, Na J, Sun T.   +16 more
europepmc   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, Volume 13, Issue 9, 13 February 2026.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Ginseng Polysaccharides Protect Against Endoplasmic Reticulum Stress-Induced Damage via PI3K/Akt Signalling Pathway in Bovine Ovarian Granulosa Cells. [PDF]

Cells
Wang H, Fang Y, Huang L, Yang X, Ma X, Lyu Y, Jing G, Ding H, Liu H, Lyu W.   +9 more
europepmc   +1 more source

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

The Potential Clinical Relevance of Necrosis-Necroptosis Pathways for Hypoxic-Ischaemic Encephalopathy. [PDF]

Cells
Lear BA, McDouall AJ, Lear OJ, Dhillon SK, Lear CA, Northington FJ, Bennet L, Gunn AJ.   +7 more
europepmc   +1 more source

NLK facilitates Caspase‐8 activation to drive macrophage PANoptosis in sepsis

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
By promoting Caspase‐8 activation within the PANoptosome, NLK modulates pyroptotic, apoptotic, and necroptotic programs in macrophages, thereby driving inflammatory injury and multiorgan damage during sepsis. Abstract Mounting evidence indicates that macrophage PANoptosis—an integrated inflammatory cell‐death program comprising pyroptosis, apoptosis ...
Yun Xia, Ren‐qi Yao, Hui‐fan Liu, Guo‐qing Jing, Delida Aidebaike, Jing Zuo, Shi‐qi Wan, Die Wu, Peng‐yue Zhao, Hai‐long Gong, Xing Wang, Hui‐min Zhou, Ning Dong, Yao Wu, Shi Liu, Xiao‐jing Wu, Yong‐ming Yao, Xue‐min Song   +17 more
wiley   +1 more source

BACH2 alleviates immune checkpoint inhibitors‐induced cardiac pyroptosis via transcriptionally promoting GRSF1

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Immune checkpoint inhibitors cause elevated cardiac injuries in humans and mice. ICIs cause myocyte pyroptosis and cardiotoxicity, not via the adaptive immune system BACH2 ameliorates ICIs‐induced pyroptosis through transcriptionally promoting GRSF1. Lipoic acid, as a transcriptional inducer of BACH2, suppresses ICIs‐induced cardiotoxicity.
Mengying Cao, Zilong Liu, Di Zhao, Hongyuan Zhang, Xinjie He, Wenhao Wang, Xiaolin Wang, Cheng Yang, Pan Gao, Yunzeng Zou   +9 more
wiley   +1 more source

ZBP1 Mediates Renal Tubular Injury in Diabetic Nephropathy Through RIPK3-mediated Necroptosis. [PDF]

Inflammation
Hu Z, Ma Y, Wang Y, Wang J, Liu X, Chen C, Zhu W, Qi X, Wu Y.   +8 more
europepmc   +1 more source