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Clinical Immunology
Autoimmunity is a normal physiological state that requires immunological homeostasis and surveillance, whereas necroptosis is a type of inflammatory cell death. When necroptosis occurs, various immune system cells must perform their appropriate duties to preserve immunological homeostasis, whether the consequence is expanding or limiting the ...
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Autoimmunity is a normal physiological state that requires immunological homeostasis and surveillance, whereas necroptosis is a type of inflammatory cell death. When necroptosis occurs, various immune system cells must perform their appropriate duties to preserve immunological homeostasis, whether the consequence is expanding or limiting the ...
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Distinguishing Necroptosis from Apoptosis
2018Apoptosis was the first programmed cell death to be defined-highly regulated and immunologically silent, as apoptotic bodies are being removed without triggering inflammation. Few decades later, necroptosis was discovered-uniquely regulated but inflammatory.
Inbar, Shlomovitz +4 more
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Tools in the Art of Studying Necroptosis
2018Necroptosis is a more recently described form of regulated cell death (RCD) that occurs in a caspase-independent manner. This is a lytic form of cell death in which the cellular contents are released and these contents serve as damage-associated molecular patterns (DAMPs).
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Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis
Cell, 2020Ting Zhang, Chaoran Yin, David F Boyd
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ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer
Nature Communications, 2021Jin Young Baik +2 more
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Molecular mechanisms of necroptosis: an ordered cellular explosion
Nature Reviews Molecular Cell Biology, 2010Peter Vandenabeele +2 more
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A killer puts a stop on necroptosis
Nature Reviews Molecular Cell Biology, 2011Katharine H Wrighton +1 more
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Parkin and AMPK team up against necroptosis
Nature Reviews Molecular Cell Biology, 2019Paulina Strzyz, Strzyz Paulina
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Molecular insights into execution of necroptosis
Nature Reviews Molecular Cell Biology, 2016Paulina Strzyz, Strzyz Paulina
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