Results 241 to 250 of about 52,832 (305)

Unlocking glioma vulnerabilities: targeting regulated cell death pathways for innovative therapies. [PDF]

Cell Death Discov
Guo J, Zong L, Huang Y, Liu X, Hu Y, Liu Y.   +5 more
europepmc   +1 more source

Ubiquitin‐Specific Protease 45 Inhibits Lung Adenocarcinoma Ferroptosis by Regulating Ubiquitination and Stability of Glutathione Peroxidase 4

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Lung adenocarcinoma is the most common subtype of lung cancer and the leading cause of cancer‐related mortality worldwide. Ferroptosis, a regulated form of cell death characterized by iron‐dependent lipid peroxidation, has emerged as a promising therapeutic target for lung adenocarcinoma.
Mingxiang Huang, Meilan Fang, Yao Wang, Shanshan Liu, Fengqin Li   +4 more
wiley   +1 more source

ALDH2 Mediated Ferroptosis Regulation in Ischemia-Reperfusion Injury. [PDF]

J Cell Mol Med
Han L, Zhai W.
europepmc   +1 more source

Plasma EDA2R and Risk of Cardiovascular Diseases and All‐Cause Mortality: Analysis of the UK Biobank Cohort

Clinical Cardiology, Volume 49, Issue 5, May 2026.
In this large‐scale UK Biobank analysis, elevated plasma EDA2R was associated with a 74% higher risk of cardiovascular disease and a 177% higher risk of all‐cause mortality, with a 7.2‐year loss in life expectancy in the highest EDA2R group, suggesting its potential as a prognostic biomarker and therapeutic target.
Ziqing Ruan, Jiabin Tu, Hongli Xu, Yupeng Zhi, Chun Chen, Kaiyang Lin, Yansong Guo   +6 more
wiley   +1 more source

vIRA Inhibition of Antiviral Necroptosis and RIPK3 Binding Are Separable Events. [PDF]

Pathogens
Ragan KB, Sridharan H, Stark AS, Ilami K, Fisher AD, Brahms ON, Kaiser WJ, Upton JW.   +7 more
europepmc   +1 more source

Hypoxia Upregulates RIPK1 via the HIF‐1α–JAK–STAT Pathway Leading to Astrocyte Necroptosis to Promote Cavitation After Spinal Cord Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Abstract This study established a rat spinal cord injury (SCI) model and an in vitro hypoxic astrocyte model, confirming that hypoxia promotes the formation of the cavity of injury (COI) after SCI by activating the HIF‐1α/JAK/STAT pathway, which in turn induces astrocytic necroptosis and ultimately drives the pathological progression of SCI.
Hangchuan Bi, Wan Zhang, Hao Duan, Chao Wang, Xianglin Shen, Gang Jiang, Haiyan Xue, Rongji Yan, Yuan Xu, Yihe Zhang, Haoyu Zhao, Fei He, Zhihua Wang   +12 more
wiley   +1 more source

Targeting regulated cell death pathways in lung cancer: mechanisms, therapeutic strategies, and clinical translation. [PDF]

Front Immunol
Xue F, Sun J, Zhang J, Shen Y.
europepmc   +1 more source

HBO‐PC Reprograms Neuroimmune Metabolism Through Disruption of the LRG1‐HIF‐1α‐IL‐6‐STAT3 Amplification Loop Attenuates Pyroptosis and Ischemia–Reperfusion Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
A mouse CIRI model was generated by middle cerebral artery occlusion. HBO‐PC and LRG1 siRNA knockdown were applied. Neurological function and molecular changes were evaluated. We confirmed that HBO‐PC reprograms neuroimmune metabolism through disruption of the LRG1‐HIF‐1α‐IL‐6‐STAT3 amplification Loop attenuates pyroptosis and ischemia–reperfusion ...
Wenying Lv, Junzhe Lv, Kexin Xiong, Shunshun Yuan, Jingyao Yang, Dazhi Guo   +5 more
wiley   +1 more source

The Intracellular C5a-mtC5aR1 Axis Promotes Necroptosis in Dry Eye Through DRP1-Mediated Mitochondrial Dysfunction. [PDF]

Invest Ophthalmol Vis Sci
Wang L, Yan H, Shen Y, Xin S, Dong C, Li J, Ren Y, Chen W, Zheng Q.   +8 more
europepmc   +1 more source