Results 301 to 310 of about 60,497 (319)

Differently surface-labeled polystyrene nanoplastics at an environmentally relevant concentration induced Crohn's ileitis-like features via triggering intestinal epithelial cell necroptosis.

Environment International, 2023
Nanoplastics (NPs), regarded as the emerging contaminants, can enter and be mostly accumulated in the digest tract, which pose the potential threat to intestinal health.
Dihui Xu, Yuhan Ma, Chunyan Peng, Yibin Gan, Yuheng Wang, Zining Chen, Xiaodong Han, Yabing Chen   +7 more
semanticscholar   +1 more source

Revealing the Mutually Enhanced Mechanism of Necroptosis and Immunotherapy Induced by Defect Engineering and Piezoelectric Effect

Advances in Materials, 2023
Owing to low immunogenicity‐induced immune escape and short‐term circulating immune responses, the efficiency of immunotherapy is unsatisfactory. Therefore, triggering immunogenic cell death and establishing a long‐term, mutually reinforced treatment ...
Yaqian Du, Jiani Yang, Fei He, Xudong Zhao, Jialing Zhou, Pengyu Zang, Changlin Liu, Ying Xie, Yanqiao Zhang, Piaoping Yang   +9 more
semanticscholar   +1 more source

Distinguishing Necroptosis from Apoptosis

2018
Apoptosis was the first programmed cell death to be defined-highly regulated and immunologically silent, as apoptotic bodies are being removed without triggering inflammation. Few decades later, necroptosis was discovered-uniquely regulated but inflammatory.
Inbar, Shlomovitz, Sefi, Zargarian, Ziv, Erlich, Liat, Edry-Botzer, Motti, Gerlic   +4 more
openaire   +2 more sources

Viral-induced neuronal necroptosis: Detrimental to brain function and regulation by necroptosis inhibitors

Biochemical Pharmacology, 2023
Neuronal necroptosis (programmed necrosis) in the CNS naturally occurs through a caspase-independent way and, especially in neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD), Parknson's disease (PD), Amyotrophic Lateral Sclerosis (ALS) and viral infections.
Siva, Prasad Panda, Adarsh, Kesharwani, Sarada, Prasanna Mallick, Dsnbk, Prasanth, Praveen, Kumar Pasala, Vinay, Bharadwaj Tatipamula   +5 more
openaire   +2 more sources

Relevance of necroptosis in cancer

Immunology & Cell Biology, 2017
Resistance to caspase‐dependent apoptosis is often responsible for treatment failures in cancer. Finding novel therapeutic strategies that can activate alternative cell death programs appears to be appealing. Necroptosis is a form of programmed necrosis that occurs under caspase‐deficient conditions.
Najoua Lalaoui, Gabriela Brumatti
openaire   +2 more sources

Neutrophil extracellular traps trigger alveolar epithelial cell necroptosis through the cGAS-STING pathway during acute lung injury in mice

International Journal on Biological Sciences
Extensive loss of alveolar epithelial cells (AECs) undergoing necroptosis is a crucial mechanism of acute lung injury (ALI), but its triggering mechanism needs to be thoroughly investigated.
Han-Xi Sha, Yu-Biao Liu, Yan-Ling Qiu, W. Zhong, Nan-Shi-Yu Yang, Chen-Yu Zhang, J. Duan, Jian-Bing Xiong, Cha-Xiang Guan, Yong Zhou   +9 more
semanticscholar   +1 more source

Necroptosis and autoimmunity

Clinical Immunology
Autoimmunity is a normal physiological state that requires immunological homeostasis and surveillance, whereas necroptosis is a type of inflammatory cell death. When necroptosis occurs, various immune system cells must perform their appropriate duties to preserve immunological homeostasis, whether the consequence is expanding or limiting the ...
openaire   +2 more sources

Necroptosis activation in Alzheimer's disease

Nature Neuroscience, 2017
Alzheimer's disease (AD) is characterized by severe neuronal loss; however, the mechanisms by which neurons die remain elusive. Necroptosis, a programmed form of necrosis, is executed by the mixed lineage kinase domain-like (MLKL) protein, which is triggered by receptor-interactive protein kinases (RIPK) 1 and 3. We found that necroptosis was activated
Caccamo, Antonella, Branca, Caterina, Piras, Ignazio S, Ferreira, Eric, Huentelman, Matthew J, Liang, Winnie S, Readhead, Ben, Dudley, Joel T, Spangenberg, Elizabeth E, Green, Kim N, Belfiore, Ramona, Winslow, Wendy, Oddo, Salvatore   +12 more
openaire   +2 more sources

Methods to Analyze Cellular Necroptosis

2009
Necroptosis is a mechanism of necrotic cell death induced by external stimuli in the form of death domain receptor (DR) engagement by their respective ligands, TNF-alpha, Fas ligand (FasL) and TRAIL, under conditions when apoptotic cell death execution is prevented, e.g. by caspase inhibitors.
Benchun, Miao, Alexei, Degterev
openaire   +2 more sources

Necroptosis: Pathway diversity and characteristics

Seminars in Cell & Developmental Biology, 2015
Regulated cell death is a physiological process that controls organismal homeostasis. Deregulation of cell death can lead to the development of a number of human diseases and tissue damage. Apoptosis is a best-known model of caspase-dependent regulated cell death, but recently necroptosis has garnered a lot of attention as a form of regulated cell ...
M Cristina, de Almagro, Domagoj, Vucic
openaire   +2 more sources