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Necroptosis in the pathophysiology of preeclampsia
Cell Cycle, 2023Necroptosis is a newly-identified form of gene-regulated cell necrosis that is increasingly considered to be a pathway associated with human pathophysiological conditions. Cells undergoing necroptosis exhibit necrotic phenotypes, including disruption of the plasma membrane integrity, organelle swelling, and cytolysis.
Hongbiao, Yu, Ling, Chen, Boyu, Du
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Biomarkers for the detection of necroptosis
Cellular and Molecular Life Sciences, 2016Necroptosis has been extensively studied recently, and the receptor-interacting kinase 3 (RIP3 or RIPK3) and its substrate, the pseudokinase mixed lineage kinase domain-like protein, have been discovered to be core components of this process. Classical necroptosis requires RIP1 (or RIPK1) for the activation of RIP3 through the induction of RIP1/RIP3 ...
Sudan, He, Song, Huang, Zhirong, Shen
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A20 is a regulator of necroptosis
Nature Immunology, 2015The anti-inflammatory molecule A20 inhibits necroptotic cell death by inhibiting ubiquitination of the kinase RIPK3 at the Lys5 residue and preventing excessive formation of the RIPK1-RIPK3 necroptotic complex.
Prajwal Gurung +2 more
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Relevance of necroptosis in cancer
Immunology & Cell Biology, 2017Resistance to caspase‐dependent apoptosis is often responsible for treatment failures in cancer. Finding novel therapeutic strategies that can activate alternative cell death programs appears to be appealing. Necroptosis is a form of programmed necrosis that occurs under caspase‐deficient conditions.
Najoua Lalaoui, Gabriela Brumatti
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Role of gasotransmitters in necroptosis
Experimental Cell ResearchGasotransmitters are endogenous gaseous signaling molecules that can freely pass through cell membranes and transmit signals between cells, playing multiple roles in cell signal transduction. Due to extensive and ongoing research in this field, we have successfully identified many gasotransmitters so far, among which nitric oxide, carbon monoxide, and ...
Lei, Cao +9 more
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Clinical Immunology
Autoimmunity is a normal physiological state that requires immunological homeostasis and surveillance, whereas necroptosis is a type of inflammatory cell death. When necroptosis occurs, various immune system cells must perform their appropriate duties to preserve immunological homeostasis, whether the consequence is expanding or limiting the ...
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Autoimmunity is a normal physiological state that requires immunological homeostasis and surveillance, whereas necroptosis is a type of inflammatory cell death. When necroptosis occurs, various immune system cells must perform their appropriate duties to preserve immunological homeostasis, whether the consequence is expanding or limiting the ...
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Distinguishing Necroptosis from Apoptosis
2018Apoptosis was the first programmed cell death to be defined-highly regulated and immunologically silent, as apoptotic bodies are being removed without triggering inflammation. Few decades later, necroptosis was discovered-uniquely regulated but inflammatory.
Inbar, Shlomovitz +4 more
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Tools in the Art of Studying Necroptosis
2018Necroptosis is a more recently described form of regulated cell death (RCD) that occurs in a caspase-independent manner. This is a lytic form of cell death in which the cellular contents are released and these contents serve as damage-associated molecular patterns (DAMPs).
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Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis
Cell, 2020Ting Zhang, Chaoran Yin, David F Boyd
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