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The CCL11-CCR3 Axis Regulates the Aggravation of Neuroinflammation in Astrocytic Necroptosis After Cerebral Ischemia. [PDF]
FASEB JYin H +10 more
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Nanoparticle-Induced Breast Cancer Cell Death: The Associated Mechanisms of Seven Major Cell Death Pathways in Preclinical Models and a Cross-Validation Model. [PDF]
CellsWang S +7 more
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Journal of Cell Science, 2022
ABSTRACT Necroptosis, or programmed necrosis, is an inflammatory form of cell death with important functions in host defense against pathogens and tissue homeostasis. The four cytosolic receptor-interacting protein kinase homotypic interaction motif (RHIM)-containing adaptor proteins RIPK1, RIPK3, TRIF (also known as TICAM1) and ZBP1 ...
Kidong Kang +2 more
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ABSTRACT Necroptosis, or programmed necrosis, is an inflammatory form of cell death with important functions in host defense against pathogens and tissue homeostasis. The four cytosolic receptor-interacting protein kinase homotypic interaction motif (RHIM)-containing adaptor proteins RIPK1, RIPK3, TRIF (also known as TICAM1) and ZBP1 ...
Kidong Kang +2 more
openaire +2 more sources
Necroptosis in atherosclerosis
Clinica Chimica Acta, 2022Atherosclerosis, a chronic inflammatory disease, is a leading cause of death worldwide. Vascular endothelial cells (VECs), vascular smooth muscle cells (VSMCs) and macrophages play extremely vital roles in the formation of atherosclerotic plaques and subsequent atherosclerosis.
Xiaofan, Zhang +3 more
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Trends in Cancer, 2017 Necroptosis is a programmed lytic cell death pathway, deregulation of which is linked to various inflammatory disorders. Escape from programmed cell death and inflammation play a significant role in cancer, and therefore, investigating the role of necroptosis in cancer has been of high interest.
Ayaz Najafov, Hongbo Chen, Junying Yuan
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Necroptosis pathways in tumorigenesis
Seminars in Cancer Biology, 2022Necroptosis is a caspase-independent form of programmed cell death executed by the receptor interacting protein kinase 1 (RIPK1)-RIPK3-mixed lineage kinase domain-like protein (MLKL) signaling cascade, deregulation of which can cause various human diseases including cancer.
Tao, Zhang +3 more
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The regulation of necroptosis by ubiquitylation
Apoptosis, 2022Necroptosis is a programmed necrosis that is mediated by receptor-interacting protein kinases RIPK1, RIPK3 and the mixed lineage kinase domain-like protein, MLKL. Necroptosis must be strictly regulated to maintain normal tissue homeostasis, and dysregulation of necroptosis leads to the development of various inflammatory, infectious, and degenerative ...
Yiliang, Chen +5 more
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Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators [PDF]
Experimental and Molecular Medicine, 2021 AbstractNecroptosis is a form of programmed necrosis that is mediated by various cytokines and pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes, including swelling and membrane rupture, and release damage-associated molecular patterns (DAMPs), inflammatory cytokines, and chemokines, thereby mediating extreme ...
Jinho Seo, Young Woo Nam, Jaewhan Song
exaly +3 more sources
Annual Review of Biochemistry, 2016
Necroptosis is a regulated form of necrosis, with the dying cell rupturing and releasing intracellular components that can trigger an innate immune response. Toll-like receptor 3 and 4 agonists, tumor necrosis factor, certain viral infections, or the T cell receptor can trigger necroptosis if the activity of the protease caspase-8 is compromised ...
Kim, Newton, Gerard, Manning
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Necroptosis is a regulated form of necrosis, with the dying cell rupturing and releasing intracellular components that can trigger an innate immune response. Toll-like receptor 3 and 4 agonists, tumor necrosis factor, certain viral infections, or the T cell receptor can trigger necroptosis if the activity of the protease caspase-8 is compromised ...
Kim, Newton, Gerard, Manning
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Necroptosis and tumor progression
Trends in Cancer, 2022Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense against certain pathogen invasions. The deregulation of necroptosis is also a key factor of many inflammatory diseases. Recent studies have revealed an important role of necroptosis in tumorigenesis and metastasis and imply the potential of targeting necroptosis as a
Jiong, Yan +3 more
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