Results 61 to 70 of about 3,363 (137)

Statin-associated muscle disorders

Indian Journal of Rheumatology, 2020
Statins are one of the most widely used and reputable medications worldwide, with strong evidence of mitigating cardiovascular complications and with a generally favorable safety profile.
Alan Xu, Vidya Limaye
doaj   +1 more source

Pembrolizumab‐Induced Myositis: Diagnostic and Therapeutic Challenges From Two Case Reports and a Narrative Review

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Pembrolizumab, an anti‐PD‐1 immune checkpoint inhibitor, has transformed the treatment of multiple solid tumors. However, it can rarely cause immune‐related myositis, which may involve limb, bulbar, and respiratory muscles, posing a risk of severe morbidity and mortality. Early recognition and management are essential. We report two
Francesca Rifaldi, Niccolò Leandro Alessio, Francesca Caspani, Elena Bolzacchini, Monica Giordano, Paolo Pedrazzoli   +5 more
wiley   +1 more source

Signal Recognition Particle Myopathy With Cardiac Manifestations in Rheumatoid Arthritis

Annals of Internal Medicine: Clinical Cases
Immune-mediated necrotizing myopathy is a rare inflammatory myopathy characterized by progressive muscle weakness and potentially severe systemic complications.
Priya Sunkara, Deepesh Yadav, Murat Gokden, Vinisha Kota   +3 more
doaj   +1 more source

A severe myopathy case in aged patient treated with high statin dosage

Toxicology Reports, 2017
Statins (S) are widely used drugs for cardiovascular prevention however their utilization may cause a various grade of muscle toxicity. Sometime S discontinuation alone is not sufficient to revert muscle injury and this can evolve in serious inflammatory
Canzonieri Elena, De Candia Cristina, Tarascio Salvatore, Giamporcaro Silvia, Lumera Giovanni, Rigano Giuseppe, Incognito Carmela, Privitera Filippo, Guarnaccia Agata, Foti Pietro Valerio, Palmucci Stefano, Gangemi Pietro, Fuccio-Sanzà Giulia, Signorelli Salvatore Santo   +13 more
doaj   +1 more source

When ‘Liver Enzymes’ Are Not Hepatic: Late‐Onset Pompe Disease

Medical Journal of Australia, Volume 224, Issue 6, June 2026.
ABSTRACT Elevated liver function tests are commonly attributed to hepatic disease but may reflect extrahepatic pathology. We describe the case of an 18‐year‐old athletic woman with a 2‐year history of elevated aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatine kinase (CK) levels, initially investigated extensively for hepatic
Shauna Madigan, Georgina England, Wayne Rankin   +2 more
wiley   +1 more source

Pembrolizumab-related systemic myositis involving ocular and hindneck muscles resembling myasthenic gravis: a case report

BMC Neurology, 2019
Background Pembrolizumab is an immune-checkpoints inhibitor that enhances the immune response against cancer cells and therefore is useful for the treatment of several carcinomas.
Hikaru Kamo, Taku Hatano, Kazuaki Kanai, Nozomi Aoki, Daiki Kamiyama, Kazumasa Yokoyama, Masashi Takanashi, Yuri Yamashita, Yasushi Shimo, Nobutaka Hattori   +9 more
doaj   +1 more source

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): A Comprehensive Review of Types, Pathophysiology, and Treatment Approaches

Brain and Behavior, Volume 16, Issue 5, May 2026.
Chronic inflammatory demyelinating polyneuropathy is an autoimmune disorder causing demyelination, leading to distal weakness, sensory loss, and autonomic dysfunction. Immune activation triggers macrophage‐mediated myelin damage and conduction failure.
Ayesha Khan, Arsal Khan, Kuldeep Dalpat Rai, Anzel Saeed, Harsh Kumar, Aneesh Kumar Sangtiani, Tehreem Fatima, Muhammad Tanveer Alam, Faiza Rajput, Sakshi Chawla, Hussain Haider Shah, Humaira Kalam   +11 more
wiley   +1 more source

Myopathy due to HMGCR antibodies in adult mimicking muscular dystrophy associated with cancer and statin exposure – narrative review of the literature – case report

Therapeutics and Clinical Risk Management, 2018
Alzira Alves de Siqueira Carvalho,1 Vinicius Gomes da Silva,1 Edmar Zanoteli,2 David Feder3 1Laboratory of Neuromuscular Disease, Department of Neurosciences, School of Medicine of ABC, Santo André, São Paulo, Brazil; 2Department of ...
Carvalho AAS, Silva VG, Zanoteli E, Feder D   +3 more
doaj  

Etiopathogenesis of Immune‐Mediated Necrotizing Myopathy: A Comprehensive Review of Recent Advances

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
This review systematically clarifies that the core of IMNM begins with specific autoantibodies, which in turn trigger complement activation, immune cell infiltration, and a storm of inflammatory factors. Together, these processes induce regulatory cell death and mitochondrial dysfunction, ultimately leading to muscle fiber necrosis. Genetic factors and
Chang Gao, Wenli Li, Qingyan Liu, Guochun Wang, Qinglin Peng   +4 more
wiley   +1 more source

Anti-HMG-CoA reductase myopathy, an undesirable evolution of statin induced myopathy: a case report

Journal of Community Hospital Internal Medicine Perspectives, 2019
Statins are commonly used lipid lowering agents which play a pivotal role in reducing cardiovascular morbidity and mortality. Often well tolerated, these HMG-CoA reductase (HMGCR) inhibitors can sometimes cause severe muscle weakness and elevated ...
Sunita Upreti, Beenish Fayyaz, Ramchandran P. Bongu   +2 more
doaj   +1 more source