Results 61 to 70 of about 119,494 (333)

Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities

open access: yesNature Communications, 2020
Necrotizing enterocolitis (NEC) is a severe, currently untreatable intestinal disease that predominantly affects preterm infants and is driven by poorly characterized inflammatory pathways.
Steven X. Cho   +54 more
semanticscholar   +1 more source

Born too early and too small: higher order cognitive function and brain at risk at ages 8–16 [PDF]

open access: yes, 2019
Prematurity presents a risk for higher order cognitive functions. Some of these deficits manifest later in development, when these functions are expected to mature. However, the causes and consequences of prematurity are still unclear.
Clark, Chris A.   +12 more
core   +5 more sources

NECROTIZING ENTEROCOLITIS

open access: yesPediatric Clinics of North America, 1996
Necrotizing enterocolitis (NEC) is the most common severe neonatal gastrointestinal emergency that predominantly affects premature infants. Its morbidity and mortality is similar to other severe childhood diseases such as meningitis and leukemia, and is becoming increasingly recognized as a major cause of neurodevelopmental delays.
openaire   +3 more sources

Necrotizing enterocolitis: current understanding of the prevention and management

open access: yesPediatric surgery international (Print)
Necrotizing enterocolitis (NEC) is one of the diseases in neonates, with a high morbidity and mortality rate, especially in preterm infants. This review aimed to briefly introduce the latest epidemiology, susceptibility factors, and clinical diagnosis ...
Xiaohan Hu   +6 more
semanticscholar   +1 more source

Behavioural and neurodevelopmental impairment at school age following necrotising enterocolitis in the newborn period.

open access: yesPLoS ONE, 2019
AimThe aim of this study was to evaluate long-term behavioural and neurodevelopmental complications of neonatal necrotizing enterocolitis at school age.MethodThis was a historic cohort study comparing all surviving children born in Denmark between 1st of
Mathias Lühr Hansen   +4 more
doaj   +1 more source

Portal venous gas resulting from umbilical vein catheterization in a very‐low‐birth‐weight infant with no interruption in early feeding

open access: yesPediatric Investigation, 2021
Introduction Portal venous gas (PVG) is common in necrotizing enterocolitis and occasionally occurs in neonates after umbilical vein catheterization (UVC). Therefore, determining the cause of PVG requires further clinical evaluation in these cases.
Jun Wang   +4 more
doaj   +1 more source

Gut bacteria and necrotizing enterocolitis: cause or effect? [PDF]

open access: yes, 2015
Development of necrotising enterocolitis (NEC) is considered to be dependent on the bacterial colonisation of the gut. With little concordance between published data and a recent study failing to detect a common strain in infants with NEC, more questions
Bloch, Sune   +7 more
core   +1 more source

Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure [PDF]

open access: yes, 2019
Growth failure during infancy is a major global problem that has adverse effects on long-term health and neurodevelopment. Preterm infants are disproportionately affected by growth failure and its effects.
Ashley, Patricia L.   +10 more
core   +1 more source

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul   +7 more
wiley   +1 more source

Expression and Possible Role of Silent Mating Type Information Regulation 2 Homolog 1 in Post-necrotizing Enterocolitis Stricture in vivo and in vitro

open access: yesFrontiers in Pediatrics, 2022
PurposeTo investigate the expression and possible role of Sirtuin1 or Silent mating–type information regulation 2 homolog-1 (SIRT1) in post-necrotizing enterocolitis stricture.Materials and MethodsThe expression characteristics of SIRT1 and TGF-β1 in ...
Rui Chen   +6 more
doaj   +1 more source

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