Results 71 to 80 of about 6,858 (167)

Rheumatoid Arthritis Associated With Anti-Signal Recognition Particle Immune-Mediated Necrotizing Myopathy: A Case Report

Journal of Investigative Medicine High Impact Case Reports
Immune-mediated necrotizing myopathy (IMNM) is a rare subtype of idiopathic inflammatory myopathy that is characterized by severe subacute proximal weakness, myofiber necrosis, and significantly elevated serum creatine kinase.
Mohamed Reda Belkhribchia MD, Johannes Alexander Lobrinus MD, Lamyaa Semlil MD, Nicolas Chauveau MD, Abdelaziz Ajrinija MD, Kristof Egervari MD, Zine Elabidine Ennhaili MD   +6 more
doaj   +1 more source

Screening of autoantibodies associated with necrotizing myopathy among undiagnosed chronic myopathy

Rinsho Shinkeigaku, 2017
We screened anti-signal recognition particle (SRP) and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies among 42 patients who had undiagnosed chronic myopathy from six national hospitals. Anti-SRP and anti-HMGCR antibodies were determined by RNA immuneprecipitation and enzyme-linked immune-sorbent assay (ELISA), respectively.
Satoshi, Kuru, Shigeaki, Suzuki, Katsuhisa, Ogata, Michio, Kobayashi, Chiho, Ishida, Chigusa, Watanabe, Tsuyoshi, Matsumura   +6 more
openaire   +3 more sources

Myopathy due to HMGCR antibodies in adult mimicking muscular dystrophy associated with cancer and statin exposure – narrative review of the literature – case report

Therapeutics and Clinical Risk Management, 2018
Alzira Alves de Siqueira Carvalho,1 Vinicius Gomes da Silva,1 Edmar Zanoteli,2 David Feder3 1Laboratory of Neuromuscular Disease, Department of Neurosciences, School of Medicine of ABC, Santo André, São Paulo, Brazil; 2Department of ...
Carvalho AAS, Silva VG, Zanoteli E, Feder D   +3 more
doaj  

Are autoantibodies pathogenic in necrotizing myopathy?

Nature Reviews Rheumatology, 2018
What causes muscle fibre necrosis in necrotizing myopathy? The authors of a new study propose that specific autoantibodies contribute to disease via immune-mediated processes; but given that these processes also occur in muscular dystrophies, how likely is that these antibodies trigger muscle fibre necrosis?
openaire   +2 more sources

Pembrolizumab-induced necrotizing diaphragmatic myositis

Journal of Mechanical Ventilation
Pembrolizumab, an anti-PD1 antibody, is increasingly used for the treatment of non-small cell lung cancer. We report a severe and poorly described adverse effect of this therapy: necrotizing myopathy with diaphragmatic and myocardial involvement.
David Rodríguez-Plaza, Carla Marco, Noemí Vidal, Enric Prats   +3 more
doaj   +1 more source

Two Cases of Statin-Induced Immune-Mediated Necrotizing Myopathy: A Rare Side Effect of Statins

Rheumato
Statins are effective drugs for lowering cholesterol and reducing cardiovascular risk. Rarely, they can trigger autoimmune myopathies like immune-mediated necrotizing myopathy (IMNM), associated with anti-HMGCR antibodies.
Luis Angel Montero Furelos, Clara Fernandez Peña, Beatriz San Millan Tejedor   +2 more
doaj   +1 more source

History of diagnosis on idiopathic inflammatory myopathy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2016
The idiopathic inflammatory myopathy (IIM) is a group of clinically heterogeneous, autoimmune-mediated disorders characterized by inflammation of muscle, elevated creatine kinase (CK), interstitial lung disease and other organ systems involvement ...
Wei ZHANG
doaj  

Therapeutic Effect Comparisons of Cyclophosphamide and Methotrexate in Immune-Mediated Necrotizing Myopathy. [PDF]

Int J Gen Med
Li Q, Zhou J, Huang W, Tang L.
europepmc   +1 more source

Etiopathogenesis of Immune-Mediated Necrotizing Myopathy: A Comprehensive Review of Recent Advances. [PDF]

CNS Neurosci Ther
Gao C, Li W, Liu Q, Wang G, Peng Q.
europepmc   +1 more source

Fatal Cardiomyopathy Secondary to Seronegative Immune-Mediated Necrotizing Myopathy: A Case Report. [PDF]

Am J Case Rep
Lueck BD, Maclean AKW, El Hasbani G, Layman AJ, Ernste FC, Arment CA.   +5 more
europepmc   +1 more source