Results 91 to 100 of about 1,008,720 (296)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Contingent Effects of Humor Type and Cognitive Style on Consumer Attitudes [PDF]

, 2016
In the spirit of examining humor contextually, we consider a basic question in this essay: do different humor types “play by the same rules,” cognitively speaking?
Kumar, Piyush, Mayer, James Mark, Peev, Plamen   +2 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Cognitive Engagement Mediates the Relationship between Positive Life Events and Positive Emotionality

Frontiers in Psychology, 2017
Need for Cognition (NFC) is conceptualized as an individuals’ tendency to engage in and enjoy effortful cognitive activity and, thus, captures one’s cognitive engagement.
Alexander Strobel, Kristin Anacker, Anja Strobel   +2 more
doaj   +1 more source

Belief Bias Effect in Older Adults: Roles of Working Memory and Need for Cognition

Frontiers in Psychology, 2020
Belief bias is the tendency in syllogistic reasoning to rely on prior beliefs rather than to fully obey logical principles. Few studies have investigated the age effect on belief bias.
Daoqun Ding, Daoqun Ding, Yang Chen, Yang Chen, Ji Lai, Ji Lai, Xiyou Chen, Meng Han, Meng Han, Xiangyi Zhang, Xiangyi Zhang   +10 more
doaj   +1 more source

The Impact of Cognitive Functioning on Daily Occupations for People with Multiple Sclerosis: A Qualitative Study [PDF]

, 2019
Background: Cognitive rehabilitation research in multiple sclerosis is ever-developing, but the impact of cognitive difficulties, seen in 40% to 80% of people, on daily occupations is not well known.
Hynes, Sinéad M, Mc Auliffe, Aoife
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Striving for accuracy attenuates the positive relationship between cyberbullying bystanders’ dispositional empathy and tendencies to help victims

Cyberpsychology: Journal of Psychosocial Research on Cyberpspace
Empathy is a key predictor of bystanders’ helping behaviors, yet its role in cyberbullying contexts has yielded inconsistent findings. This study investigated whether accuracy motivation, the drive to form correct and well-reasoned judgments, moderates ...
Cheng-Hong Liu, Fa-Chung Chiu, Po-Sheng Huang, Ting-Huan Lin, Chia-Lin Chang   +4 more
doaj   +1 more source

Convergent? Minds? Some questions about mental evolution [PDF]

, 2017
In investigating convergent minds, we need to be sure that the things we are looking at are both minds and convergent. In determining whether a shared character state represents a convergence between two organisms, we must know the wider distribution and
Cartmill, Matt
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source