Results 1 to 10 of about 109,824 (227)

Differential Effects of Human Immunodeficiency Virus Nef Variants on Pulmonary Vascular Endothelial Cell Dysfunction [PDF]

Infectious Disease Reports
Background: Human Immunodeficiency Virus (HIV) infections remain a source of cardiopulmonary complications among people receiving antiretroviral therapy.
Amanda K. Garcia, Noelia C. Lujea, Javaria Baig, Eli Heath, Minh T. Nguyen, Mario Rodriguez, Preston Campbell, Isabel Castro Piedras, Edu Suarez Martinez, Sharilyn Almodovar   +9 more
doaj   +2 more sources

HIV-1 Nef activates proviral DNA transcription by recruiting Src kinase to phosphorylate host protein Nef-associated factor 1 to compromise its viral restrictive function [PDF]

Journal of Virology
HIV-1 accessory protein Nef is a multifunctional pathogenic factor that mediates immune evasion, enhances virion infectivity, antagonizes host restrictive factors, and promotes viral dissemination.
Tian-Jiao Fan, Chengzuo Xie, Lisha Li, Xia Jin, Jie Cui, Jian-Hua Wang   +5 more
doaj   +2 more sources

Genetic determinants of HIV-1 subtype C Nef-mediated SERINC3 down-regulation [PDF]

Virology Journal
Background Nef-mediated down-regulation of the host restriction factors SERINC3 and SERINC5 significantly enhances HIV-1 infectivity. Natural Nef polymorphisms that affect SERINC3 down-regulation are not as well-characterised as those that affect SERINC5
Nikeisha Samlall, Tarylee Reddy, Nasreen Ismail, Mark A. Brockman, Zabrina L. Brumme, Thumbi Ndung’u, Jaclyn K. Mann   +6 more
doaj   +2 more sources

Diagnóstico incidental de apendicitis aguda por colonoscopia, reporte de un caso

Revista Ciencias Biomédicas, 2021
Introducción: la apendicitis aguda es una de las causas más comunes de abdomen agudo y una de las indicaciones más frecuentes de cirugía abdominal de urgencia.
Iván Aguancha Segebre, Gonzalo Araneda Muñoz, Alejandro Ceriani Bravo, Gabriel Antonio Arrieta Pérez, Jorge Vega Stieb, Francisco Palma Carvajal   +5 more
doaj   +1 more source

Sildenafil for treating patients with COVID-19 and perfusion mismatch: a pilot randomized trial

Critical Care, 2022
Background SARS-CoV-2 seems to affect the regulation of pulmonary perfusion. Hypoperfusion in areas of well-aerated lung parenchyma results in a ventilation–perfusion mismatch that can be characterized using subtraction computed tomography angiography ...
Mario G. Santamarina, Ignacio Beddings, Felipe Martinez Lomakin, Dominique Boisier Riscal, Mónica Gutiérrez Claveria, Jaime Vidal Marambio, Nicole Retamal Báez, Cristian Pavez Novoa, César Reyes Allende, Paulina Ferreira Perey, Miguel Gutiérrez Torres, Camila Villalobos Mazza, Constanza Vergara Sagredo, Sebastian Ahumada Bermejo, Eduardo Labarca Mellado, Elizabeth Barthel Munchmeyer, Solange Marchant Ramos, Mariano Volpacchio, Jorge Vega   +18 more
doaj   +1 more source

Malignancy risk of thyroid nodules with nonshadowing echogenic foci [PDF]

Ultrasonography, 2021
Purpose This study was conducted to determine the malignancy risk and diagnostic value of various types of nonshadowing echogenic foci (NEF) in the risk stratification of thyroid nodules.
Yu-Mee Sohn, Dong Gyu Na, Wooyul Paik, Hye Yun Gwon, Byeong-Joo Noh   +4 more
doaj   +1 more source

HIV-1 Nef synergizes with APOL1-G1 to induce nephrocyte cell death in HIV-related kidney diseases

Disease Models & Mechanisms
Jun-yi Zhu, Yulong Fu, Joyce van de Leemput, Jing Yu, Jinliang Li, Patricio E. Ray, Zhe Han   +6 more
doaj   +2 more sources

Identificação de pacientes com hipertensão resistente e pseudorresistente em uma Unidade de Saúde da Família [PDF]

Infarma: Pharmaceutical Sciences, 2017
A Hipertensão Resistente (HAR) se manifesta quando os valores de pressão arterial (PA) permanecem acima da meta, apesar do uso regular de três classes de fármacos anti-hipertensivos, incluindo um diurético.
Felipe Vieira da SILVA, Martha Gabriela Zambrana de AMORIM, Alfredo Dias de OLIVEIRA FILHO, Sabrina Joany Felizardo NEVES   +3 more
doaj   +1 more source

Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. [PDF]

PLoS ONE, 2011
Increased spread of HIV-1 and rapid emergence of drug resistance warrants development of novel antiviral strategies. Nef, a critical viral pathogenicity factor that interacts with host cell factors but lacks enzymatic activity, is not targeted by current
Sebastian Breuer, Simone I Schievink, Antje Schulte, Wulf Blankenfeldt, Oliver T Fackler, Matthias Geyer   +5 more
doaj   +1 more source

COVID-19 pneumonia: Perfusion abnormalities shown on subtraction CT angiography in apparently well-ventilated lungs. A prospective cohort study

Heliyon, 2023
Purpose: To evaluate whether a subtraction CT angiography (sCTA) perfusion score may have prognostic value in patients with COVID-19 pneumonia. Method: This prospective cohort study included adult patients with RT-PCR-confirmed SARS-CoV-2 infection ...
Mario G. Santamarina, Felipe Martinez Lomakin, Ignacio Beddings, Dominique Boisier Riscal, Jose Chang Villacís, Roberto Contreras, Jaime Vidal Marambio, Eduardo Labarca, Jorge Torres, Mariano Volpacchio   +9 more
doaj   +1 more source